Abstract: The present invention relates to an adenine base editor (ABE), and components thereof. The present invention also relates to a complex comprising an adenine base editor (ABE) and a guide RNA in a functionally associated form. The present invention further relates to a nucleic acid molecule encoding the ABE/guide RNA, an expression construct or a vector comprising a nucleic acid sequence encoding the adenine base editor and/or the nucleic acid sequence encoding the guide RNA. The present invention further relates to a cell comprising an adenine base editor (ABE) and a method of adenine base editing of a target site in a genome of interest in at least one cell of a prokaryotic organism, including bacterial and archaeal organisms, or eukaryotic organism. Besides that, the present invention relates to various methods, kits and uses associated with the ABEs provided.

Abstract: Systems and methods for lifelong schema matching are described. The systems and methods include receiving data comprising a plurality of information categories, classifying each information category according to a schema comprising a plurality of classes, wherein the classification is performed by a neural network classifier trained based on a lifelong learning technique using a plurality of exemplar training sets, wherein each of the exemplar training sets includes a plurality of examples corresponding to one of the classes, and wherein the examples are selected based on a metric indicating how well each of the examples represents the corresponding class, and adding the data to a database based on the classification, wherein the database is organized according to the schema.

Abstract: In some embodiments, a model training system trains a sample generation model configured to generate synthetic data entries for a dataset. The sample generation model includes a prior model for generating an estimated latent vector from a partially observed data entry, a proposal model for generating a latent vector from a data entry of the dataset and a mask corresponding to the partially observed data entry, and a generative model for generating the synthetic data entries from the latent vector and the partially observed data entry. The model training system trains the sample generation model to optimize an objective function that includes a first term determined using the synthetic data entries and a second term determined using the estimated latent vector and the latent vector. The trained sample generation model can be executed on a client computing device to service queries using the generated synthetic data entries.

Abstract: In some embodiments, a model training system trains a sample generation model configured to generate synthetic data entries for a dataset. The sample generation model includes a prior model for generating an estimated latent vector from a partially observed data entry, a proposal model for generating a latent vector from a data entry of the dataset and a mask corresponding to the partially observed data entry, and a generative model for generating the synthetic data entries from the latent vector and the partially observed data entry. The model training system trains the sample generation model to optimize an objective function that includes a first term determined using the synthetic data entries and a second term determined using the estimated latent vector and the latent vector. The trained sample generation model can be executed on a client computing device to service queries using the generated synthetic data entries.

Abstract: Systems and methods for lifelong schema matching are described. The systems and methods include receiving data comprising a plurality of information categories, classifying each information category according to a schema comprising a plurality of classes, wherein the classification is performed by a neural network classifier trained based on a lifelong learning technique using a plurality of exemplar training sets, wherein each of the exemplar training sets includes a plurality of examples corresponding to one of the classes, and wherein the examples are selected based on a metric indicating how well each of the examples represents the corresponding class, and adding the data to a database based on the classification, wherein the database is organized according to the schema.

Abstract: The present invention comprises a system for associating requests with potential respondents to those requests. The system facilitates the purchasing of goods and/or services, knowledge-based inquiries, and matching common interest groups by associating requests with category designations and providing potential respondents with access to the requests.

Abstract: One embodiment of the present invention provides a system that facilitates issuing rights in a digital rights management system. The system operates by sending a request to perform an operation on an item of content from a client to a rights-management server, wherein the request includes a usage parameter which specifies constraints involved in performing the operation. Next, the system receives a response from the rights-management server, wherein the response indicates whether or not the client has rights to perform the operation in accordance with the constraints specified by the usage parameter. Note that the response may also include a hint that facilitates generating subsequent requests to perform the operation. Finally, if the client has rights to perform the operation, the system performs the operation on the item of content.

Abstract: Stoves having a ceramic cooktop mounted within a metal frame with a silicone sealant therebetween are manufactured in a labor saving process involving minimal waste, hand tooling, and cleanup, by providing a leakage-preventing dam paralleling the periphery of the cooktop support surface, positioning the cooktop within the frame, resting on the dam, and applying as a seal, a flowable, curable silicone which cures at a rate such as to allow it to self level, the dam preventing leakage of low viscosity silicone into the stove interior.

Abstract: The present invention comprises a system for associating requests with potential respondents to those requests. The system facilitates the purchasing of goods and/or services, knowledge-based inquiries, and matching common interest groups by associating requests with category designations and providing potential respondents with access to the requests.

Abstract: Filing device (1) for filling containers (5, 54, 56) with foods and closing said containers, comprising an endless conveyor system (2) with drive means (3), for conveying container holders (4, 55) along an imaginary looped conveyor track with bottom and top track sections (11, 12) that are connected to each other by means of bend sections (12), a container infeed mechanism (17, 52, 53), at least one processing line provided along the conveyor track, a housing (15, 61) that at least partially encloses the processing line, and gas supply means (25, 65) for feeding conditioned gasses into the housing. The workstations are disposed along the conveyor track. A central area (13, 67) is defined between the top and bottom track sectons and the bend sections of the at least one processing line situated along the conveyor track, and gas discharge means (66) are provided for discharging by way of the central area at least part of the gases conveyed into the housing.

Abstract: A stent-graft with increased longitudinal flexibility that is deployed within a body lumen for supporting the lumen and repairing luminal aneurysms. In a preferred embodiment, the stent-graft is located and expanded within a blood vessel to repair aortic aneurysms. The stent-graft is comprised of an expandable stent portion, an expandable graft portion and at least one elongated rail. The stent portion and graft portion are moveable between the terminal ends of the rail(s) and relative to the rails so that it can conform to the shape of a vessel in which it is deployed. The stent-graft provides increased longitudinal flexibility within a vessel. Also, the stent-graft of the present invention does not kink after expansion, and thus, eliminates the potential for the graft portion occluding the blood flow lumen of the vessel in which it is deployed. Moreover, the wear on the graft is reduced and its longevity increased.

Abstract: Filling device (1) for filling containers (5) with foods and closing said containers, comprising an endless conveyor system (2), a filling station (21) and a closing station (22), a housing (15) that at least partially encloses the processing line which is provided along the conveyor track, and gas supply means (25) for feeding conditioned gases into the housing. The housing (15) extends at least along the filling station (21) and the closing station (22), inside which housing the gas supply means (25) are designed so that, during operation, the gases flow substantially close to the filling aperture along the outside of the containers (5), in the direction of bottoms of said containers. The gas supply means comprise a plurality of adjacent gas outflow apertures opening into the housing, and for substantially each conveyance position of a container along the housing, at least one of the gas outflow apertures is situated at a distance of less than 25 centimeters from the corresponding container aperture.

Abstract: The present invention is directed to a storage apparatus for a surgical implant device that protects the integrity of a surgical implant device during transport, provides protection of the surgical implant device prior to the use of the device in surgery, and facilitates the handling of the surgical implant device by the operator.

Abstract: Apparatus, systems and methods are provided for the warming of materials. In an embodiment, the heat for warming the materials is provided by an activatable heating substance, such as a supercooled salt solution. In an embodiment, an apparatus maintains fluid at a preselected temperature for prolonged durations. In an embodiment, an apparatus may be sterilized for deployment in a sterile surgical field. In an embodiment, an apparatus may be reused. In an embodiment, an apparatus is adapted for easy pouring of contents.

Abstract: A ski pole handle strap comprising a main wrist strap forming a loop and a secondary thumb strap connected to the main strap which divides the loop into first and second loops such that the wrist of a skier is retained by the first loop and the thumb of the skier is retained by the second loop. If a skier's grasp on the wrist strap is lost the thumb strap retains the ski pole close enough to the skier's hand to allow the skier to regain their grip.