Abstract: The invention relates to the treatment of neurodevelopmental disorders using an inhibitor of rho kinase. Preferred methods contemplate the treatment of infants and children. Certain embodiments involve treating a neurodevelopmental disorder is caused by defects of metabolism, including defects of amino acid transport or metabolism, acid-base balance, carbohydrate transport or metabolism, metal homeostasis, neurotransmitter metabolism, or fatty acid transport or metabolism. Methods address a variety of conditions caused by changes in the genetic material that affect the structure and/or expression of certain genes. Preferred methods treat Down syndrome, Fragile X syndrome, oligophrenin 1 deficiency, Rett syndrome, autistic disorder, Asperger's syndrome, pervasive developmental disorder not otherwise specified, and other autism spectrum disorders.

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

Abstract: An electrical switch assembly comprises a generally planar substrate. A functional switch and at least one identification switch are mounted to the substrate. A switch body supports a switch actuator which is movable between multiple positions. An arrangement of one or more projecting members extends from the switch body. The switch body is mounted on or to the substrate such that the switch actuator operatively engages the functional switch, and the arrangement of projecting members operatively engages at least one of the identification switches to create a unique electronic identifier for the electrical switch assembly.

Abstract: An electrical assembly including a housing having an inner surface. At least one mounting feature protrudes from the inner surface. At least one heat sink is inserted onto the at least one mounting feature. At least one electrical component is in thermal contact with a portion of the at least one heat sink.

Abstract: An operator control assembly including at least one operator control mounted in a panel cover or dashboard with at least one opening for receivably mounting the operator control, and at least one printed circuit board mounted beneath the panel cover. A unique configuration of projecting members on the bottom of the operator control comes in contract with and engages sensors mounted on the printed circuit board. Depending on the number and arrangement of the projecting members, a unique subset o sensors t engaged, providing a unique electronic ID for each operator control installed. This electronic ID can then be transmitted to an electronic control unit, which will alter its operation based on the types of operator controls currently installed.

Abstract: An electronic module includes a housing with at least two housing parts; a cable including a sheath end and a plurality of conductors extending from the sheath end; and a one-piece, multi-function seal between the cable and the housing. The multi-function seal includes a cable seal overmolded on the cable at the sheath end with the plurality of conductors being exposed from the multi-function seal. The multi-function seal further includes an integral gasket extending from the cable seal and positioned between at least two housing parts.

Abstract: An electrical switch assembly comprises a generally planar substrate. A functional switch and at least one identification switch are mounted to the substrate. A switch body supports a switch actuator which is movable between multiple positions. An arrangement of one or more projecting members extends from the switch body. The switch body is mounted on or to the substrate such that the switch actuator operatively engages the functional switch, and the arrangement of projecting members operatively engages at least one of the identification switches to create a unique electronic identifier for the electrical switch assembly.

Abstract: An operator control assembly including at least one operator control mounted in a panel cover or dashboard with at least one opening for receivably mounting the operator control, and at least one printed circuit board mounted beneath the panel cover. A unique configuration of projecting members on the bottom of the operator control comes in contract with and engages sensors mounted on the printed circuit board. Depending on the number and arrangement of the projecting members a unique subset o sensors t engaged, providing a unique electronic ID for each operator control installed. This electronic ID can then be transmitted to an electronic control unit, which will alter its operation based on the types o operator controls currently installed.

Abstract: An electronic module includes a housing with at least two housing parts; a cable including a sheath end and a plurality of conductors extending from the sheath end; and a one-piece, multi-function seal between the cable and the housing. The multi-function seal includes a cable seal overmolded on the cable at the sheath end with the plurality of conductors being exposed from the multi-function seal. The multi-function seal further includes an integral gasket extending from the cable seal and positioned between at least two housing parts.

Abstract: A connector assembly comprising includes a housing with a wall and a plurality of connector units. The wall includes a plurality of openings having the same size and shape. Each of the connector units has a base plate, electrical connectors mounted in and projecting from the base plate, a hollow shroud surrounding the electrical connectors and extending away from the base plate, and a skirt surrounding the shroud. The skirt projects radially outwardly from the base plate. All of the skirts have the same outer peripheral size and shape. The shrouds may have a variety of different outer peripheral shapes and sizes corresponding to unique connector functions. Each of the skirts sealingly engage with a portion of the wall surrounding a corresponding opening. Each opening is surrounded by a groove, and each skirt overlaps and covers a corresponding one of the grooves.

Abstract: A work machine includes a bulkhead separating an operator cab from an engine compartment. An electronic module includes a cantilever arranged mounting flange mounted to the bulkhead. The electronic module includes a rigid and thermally conductive frame. An electronics board is mounted to one side of the frame, and a power board is mounted to an opposite side of the frame. The electronics board carries a plurality of electronic components, and the power board carries a plurality of replaceable power elements. Each power element is a fuse, relay and/or circuit breaker. A housing encloses the electronics board and the power board. The housing includes an access cover to the power board.

Abstract: An electrical assembly including a housing having an inner surface. At least one mounting feature protrudes from the inner surface. At least one heat sink is inserted onto the at least one mounting feature. At least one electrical component is in thermal contact with a portion of the at least one heat sink.

Abstract: A vehicle having a power and information system including a vehicle structural member, an insulated power conductor, a communication link and a modular distribution system. The modular distribution system is attached to the vehicle structural member. The modular distribution system is coupled with the power conductor and with the communication link. The modular distribution system includes a backbone module having an electrical power connection and at least one plug pack. Each plug pack includes a first connector, a second connector and a controller pack. The first connector is connectable to the backbone module. The second connector has a plurality of terminals. The controller pack selectively electrically connects at least one of the plurality of terminals to the electrical power connection dependent upon information received by way of the communication link.

Abstract: A vehicle having a power and information system including a vehicle structural member, an insulated power conductor, a communication link and a modular distribution system. The modular distribution system is attached to the vehicle structural member. The modular distribution system is coupled with the power conductor and with the communication link. The modular distribution system includes a backbone module having an electrical power connection and at least one plug pack. Each plug pack includes a first connector, a second connector and a controller pack. The first connector is connectable to the backbone module. The second connector has a plurality of terminals. The controller pack selectively electrically connects at least one of the plurality of terminals to the electrical power connection dependent upon information received by way of the communication link.

Abstract: A work machine includes a bulkhead separating an operator cab from an engine compartment. An electronic module includes a cantilever arranged mounting flange mounted to the bulkhead. The electronic module includes a rigid and thermally conductive frame. An electronics board is mounted to one side of the frame, and a power board is mounted to an opposite side of the frame. The electronics board carries a plurality of electronic components, and the power board carries a plurality of replaceable power elements. Each power element is a fuse, relay and/or circuit breaker. A housing encloses the electronics board and the power board. The housing includes an access cover to the power board.

Abstract: A remote firing system for remotely detonating explosive charges includes features that provide safety and efficiency improvements. These features include safety communication among multiple remote devices and multiple controller devices, a polling functionality permitting rapid deployment of system devices, electronic key systems, and programmable remote devices for easy replacement of failing remote devices.

Abstract: An electrical connector assembly has first and second connector units which are connectable with each other. One of the connectors has a shell which has a variable number of tabs projecting therefrom. The number and position of the tabs can be selected so that different connectors can be distinguished from each other. A set of switches are mounted on a base adjacent the other connector. The switches are engagable tabs so that the status of the switches represents the number and position of the tabs, thereby generating electrical signals uniquely identifying the connectors.

Abstract: Low-cost, high performance access is provided to an Internet service provider (ISP) not convenient to a high volume Internet exchange point using a flexible hybrid terrestrial-satellite Internet communications system and method. The system and method provide high volume connectivity between an Internet service provider (ISP) and a remote customer site that generates a request for content to be supplied by the ISP. In an exemplary system, a first gateway processes a request for content generated at the remote customer site and routes the request. A second gateway processes the request routed by the first gateway to route the request to the content provider. One or more satellites are used to transmit requested content supplied by the ISP to the remote customer site.

Abstract: A circuit assembly includes a printed circuit board which has a plurality of copper traces formed thereon. Heat generating electronic components are surface mounted on the board in contact with parts of the traces. A heat conducting copper plate is mounted on the board adjacent to and spaced apart from the electronic components, and in contact with other parts of the traces. A silicon pad is mounted on the plate, and a heat sink member is mounted on the pad so that the pad is between the heat sink member and the traces. Heat conducting solder bridges are formed between the edges of the electronic components and the edges of the plate.

Abstract: Low-cost, high performance access is provided to a group of Internet service providers (ISPs) not convenient to a high volume Internet exchange point through a flexible hybrid terrestrial-satellite Internet communication system. Asymmetric hybrid circuits, that combine satellite and terrestrial backbone technologies, are used to handle asymmetry resulting from low volume requests and high volume responses. A user request is coupled via routers and servers to a point of presence (POP) on a group ISP backbone network. The ISP's backbone couples ISP's POPs to a terrestrial gateway location, which is coupled to a high volume ISP peered with other high volume ISPs. Requests are directed to the high volume ISP through a POP on the backbone of the high volume ISP. Responses from the high volume ISP are routed to a hybrid network provider. Responses packets are translated into permanent virtual circuits (PVC) by a router.