Patents by Inventor Thomas JAECKLIN

Thomas JAECKLIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating cholestasis
    Patent number: 11918578
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Grant
    Filed: October 5, 2022
    Date of Patent: March 5, 2024
    Assignee: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas Jaecklin, Alejandro Dorenbaum
  • METHODS FOR TREATING CHOLESTASIS
    Publication number: 20230190742
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 µg/kg/day.
    Type: Application
    Filed: October 5, 2022
    Publication date: June 22, 2023
    Applicant: Mirum Pharmaceuticals, inc.
    Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
  • Methods for treating cholestasis
    Patent number: 11497745
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: November 15, 2022
    Assignee: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas Jaecklin, Alejandro Dorenbaum
  • METHODS FOR TREATING CHOLESTASIS
    Publication number: 20220160726
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 26, 2022
    Applicant: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
  • METHODS FOR INCREASING GROWTH IN PEDIATRIC SUBJECTS HAVING CHOLESTATIC LIVER DISEASE
    Publication number: 20220152022
    Abstract: Provided herein are methods for increasing growth in a pediatric subject having a cholestatic liver disease. The method includes administering to the subject an effective amount of an ASBTI.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 19, 2022
    Applicant: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
  • GENOTYPE AND DOSE-DEPENDENT RESPONSE TO AN ASBTI IN PATIENTS WITH BILE SALT EXPORT PUMP DEFICIENCY
    Publication number: 20220133738
    Abstract: Provided herein are methods for treating or ameliorating cholestatic liver disease in a subject in need thereof. The methods include administering an Apical Sodium-dependent Bile Acid Transport Inhibitor (ASBTI) to the subject. The methods include determining a genotype of the subject and predicting subject response to the ASBTI administration based upon the genotype. The methods further include determining, adjusting, or modulating a dose of the ASBTI administered to the subject based upon the genotype or upon measurements of clinically relevant disease parameters.
    Type: Application
    Filed: February 12, 2020
    Publication date: May 5, 2022
    Applicant: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
  • METHODS FOR TREATING CHOLESTASIS
    Publication number: 20220105092
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Applicant: Mirum Pharmaceuticals, Inc.
    Inventors: Thomas Jaecklin, Alejandro Dorenbaum
  • Methods for treating cholestasis
    Patent number: 11229647
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: January 25, 2022
    Assignee: MIRUM PHARMACEUTICALS, INC.
    Inventors: Thomas Jaecklin, Alejandro Dorenbaum
  • METHODS FOR TREATING CHOLESTASIS
    Publication number: 20210113585
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Application
    Filed: December 11, 2020
    Publication date: April 22, 2021
    Applicant: Mirum Pharmaceuticals, Inc.
    Inventor: Thomas Jaecklin
  • METHODS FOR TREATING CHOLESTASIS
    Publication number: 20200375989
    Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicant: Mirum Pharmaceuticals, Inc.
    Inventor: Thomas JAECKLIN