Patents by Inventor Thomas JAECKLIN
Thomas JAECKLIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260183282Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: October 3, 2025Publication date: July 2, 2026Applicant: Mirum Pharmaceuticals, Inc.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Patent number: 12599602Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: GrantFiled: January 25, 2024Date of Patent: April 14, 2026Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Patent number: 12576079Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: GrantFiled: December 11, 2020Date of Patent: March 17, 2026Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Publication number: 20250360127Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: July 16, 2025Publication date: November 27, 2025Applicant: Mirum Pharmaceuticals, Inc.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Publication number: 20240207260Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: January 25, 2024Publication date: June 27, 2024Applicant: Mirum Pharmaceuticals, Inc.Inventors: Thomas JAECKLIN, Alejandro Dorenbaum
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Publication number: 20240189308Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: January 19, 2024Publication date: June 13, 2024Applicant: Mirum Pharmaceuticals, Inc.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Publication number: 20240173317Abstract: Provided herein are methods for treating cholestasis in a subject having liver disease. More specifically, the present invention relates to methods for treating Progressive Familial Intrahepatic Cholestasis (PFIC) in a subject where the method includes administering maralixibat to a subject in need thereof.Type: ApplicationFiled: October 23, 2023Publication date: May 30, 2024Applicant: MIRUM PHARMACEUTICALS, INC.Inventor: Thomas JAECKLIN
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Patent number: 11918578Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: GrantFiled: October 5, 2022Date of Patent: March 5, 2024Assignee: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Publication number: 20230190742Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 µg/kg/day.Type: ApplicationFiled: October 5, 2022Publication date: June 22, 2023Applicant: Mirum Pharmaceuticals, inc.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Patent number: 11497745Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: GrantFiled: December 17, 2021Date of Patent: November 15, 2022Assignee: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Publication number: 20220160726Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: February 12, 2020Publication date: May 26, 2022Applicant: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Publication number: 20220152022Abstract: Provided herein are methods for increasing growth in a pediatric subject having a cholestatic liver disease. The method includes administering to the subject an effective amount of an ASBTI.Type: ApplicationFiled: February 12, 2020Publication date: May 19, 2022Applicant: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Publication number: 20220133738Abstract: Provided herein are methods for treating or ameliorating cholestatic liver disease in a subject in need thereof. The methods include administering an Apical Sodium-dependent Bile Acid Transport Inhibitor (ASBTI) to the subject. The methods include determining a genotype of the subject and predicting subject response to the ASBTI administration based upon the genotype. The methods further include determining, adjusting, or modulating a dose of the ASBTI administered to the subject based upon the genotype or upon measurements of clinically relevant disease parameters.Type: ApplicationFiled: February 12, 2020Publication date: May 5, 2022Applicant: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas JAECKLIN, Alejandro DORENBAUM
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Publication number: 20220105092Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: December 17, 2021Publication date: April 7, 2022Applicant: Mirum Pharmaceuticals, Inc.Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Patent number: 11229647Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: GrantFiled: August 14, 2020Date of Patent: January 25, 2022Assignee: MIRUM PHARMACEUTICALS, INC.Inventors: Thomas Jaecklin, Alejandro Dorenbaum
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Publication number: 20210113585Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: December 11, 2020Publication date: April 22, 2021Applicant: Mirum Pharmaceuticals, Inc.Inventor: Thomas Jaecklin
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Publication number: 20200375989Abstract: Provided herein are methods for treating cholestasis in a subject having a liver disease. The method includes administering to the subject an Apical Sodium-dependent Bile Acid Transporter (ASBTI). More specifically, the present invention relates to methods for treating cholestasis in a subject where the method includes administering an ASBTI to a subject at a dose of at least 10 ?g/kg/day.Type: ApplicationFiled: August 14, 2020Publication date: December 3, 2020Applicant: Mirum Pharmaceuticals, Inc.Inventor: Thomas JAECKLIN