Patents by Inventor Thomas James Beauchamp

Thomas James Beauchamp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AT2R ANTAGONISTS AND USES THEREOF
    Publication number: 20230373919
    Abstract: This invention provides certain piperidine compounds as AT2R antagonists, e.g., compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and X are as defined herein, pharmaceutical compositions thereof, and methods of using the same to treat pain associated with AT2R activity.
    Type: Application
    Filed: May 11, 2023
    Publication date: November 23, 2023
    Inventors: Thomas James BEAUCHAMP, Zhaogen CHEN, Scott Eugene CONNER, Jon Andre ERICKSON, Maria Cristina GARCIA PAREDES, Jayana Pankajkumar LINESWALA, Emanuele SHER, Bishnu THAPA, Leonard Larry WINNEROSKI, II
  • 2-oxo-1,3,8-triazaspiro[4.5]decan-3-yl] carboxylic acid derivatives
    Patent number: 9920056
    Abstract: The present invention provides compounds of Formula 1, where A is selected from and R1, R2 and R3 are defined in the specification, or a pharmaceutically acceptable salt thereof, methods of using the compounds to treat diabetes, and processes for the synthesis of the compounds.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: March 20, 2018
    Assignee: Eli Lilly and Company
    Inventors: Thomas James Beauchamp, David Andrew Coates, Maria Angeles Martinez-Grau, Miguel Angel Toledo
  • 2-OXO-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL] CARBOXYLIC ACID DERIVATIVES
    Publication number: 20160368922
    Abstract: The present invention provides compounds of Formula 1, where A is selected from and R1, R2 and R3 are defined in the specification, or a pharmaceutically acceptable salt thereof, methods of using the compounds to treat diabetes, and processes for the synthesis of the compounds.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 22, 2016
    Inventors: Thomas James Beauchamp, David Andrew Coates, Maria Angeles Martinez-Grau, Miguel Angel Toledo
  • Bicyclic pyrimidine compounds
    Patent number: 8969555
    Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: March 3, 2015
    Assignee: Eli Lilly and Company
    Inventors: Thomas James Beauchamp, Yen Dao, Spencer Brian Jones, Bryan Hurst Norman, Lance Allen Pfeifer
  • Bicyclic Pyrimidine Compounds
    Publication number: 20140200231
    Abstract: The present invention provides compounds of the Formula I: wherein X is a bond or CH2; R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N; R3 is H or CH3; R4 is H or CH3; L is selected from the group consisting of —O(CH2)3—, —C(O)NH(CH2)2—, —CH2C(O)NH(CH2)2—, —(CH2)3N(C(O)CH3)CH2—, —(CH2)2N(C(O)CH3)CH2—, —(CH2)3NH—, (CH2)2OCH2—, —(CH2)4—, —(CH2)2NHCH2—, —(CH2)3O—, and —CH2O(CH2)2—; or a pharmaceutically acceptable salt thereof. Compounds of this invention are autotaxin inhibitors.
    Type: Application
    Filed: January 7, 2014
    Publication date: July 17, 2014
    Applicant: Eli Lilly and Company
    Inventors: Thomas James Beauchamp, Yen Dao, Spencer Brian Jones, Bryan Hurst Norman, Lance Allen Pfeifer
  • Inhibitors of diacylglycerol acyltransferase
    Patent number: 8299061
    Abstract: This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: October 30, 2012
    Assignee: Eli Lilly and Company
    Inventors: Macklin Brian Arnold, Thomas James Beauchamp, Emily Jane Canada, Erik James Hembre, Jianliang Lu, John Robert Rizzo, John Mehnert Schaus, Qing Shi
  • Inhibitors of Diacylglycerol Acyltransferase
    Publication number: 20110144091
    Abstract: This invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof; as well as a method for treating obesity, a method for treating diabetes, and a pharmaceutical composition.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 16, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Macklin Brian Arnold, Thomas James Beauchamp, Emily Jane Canada, Erik James Hembre, Jianliang Lu, John Robert Rizzo, John Mehnert Schaus, Qing Shi