Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: In one embodiment, a medical circuit component for use with humidified gases is described. The medical circuit conduit includes: a body comprising a wall having an inner surface that defines a space within which humidified gases may flow and/or be contained; and moisture transport means and/or element(s) at least partially coupled to and/or at least partially integrated into at least a part of the wall, the moisture transport means and/or element(s) being configured to receive moisture from vapors and/or liquid inside the space and transport at least some of said moisture away from where it was received.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: A pressure regulating or pressure relief device comprises an inlet and an outlet chamber with an outlet. The inlet is in fluid communication with the outlet chamber. A valve seat is located between the inlet and the outlet. A valve member is biased to seal against the valve seat, and displaces from the valve seat by an inlet pressure at the inlet increasing above a pressure threshold to allow a flow of gases from the inlet to the outlet via the outlet chamber. The flow of gases through the outlet causes an outlet pressure in the outlet chamber to act on the valve member together with the inlet pressure to displace the valve member from the valve seat.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: In one embodiment, a medical circuit component for use with humidified gases is described. The medical circuit conduit includes: a body comprising a wall having an inner surface that defines a space within which humidified gases may flow and/or be contained; and moisture transport means and/or element(s) at least partially coupled to and/or at least partially integrated into at least a part of the wall, the moisture transport means and/or element(s) being configured to receive moisture from vapors and/or liquid inside the space and transport at least some of said moisture away from where it was received.

Abstract: A medical tube comprises a tail to connect an embedded wire to an electrical component. The tail may comprise a flattened portion and an exposed portion to facilitate attachment of the medical tube to an electrical component. The tail may comprise a second flattened portion. One or more wires, such as a heater wire or a sensor wire, may be embedded in the medical tube. The medical tube may comprise a connector that comprises a printed circuit board to which the one or more wires is attached. The connector may comprise features to support the printed circuit board, aid in assembly of the one or more wires to the connector, and protect electrical components against liquid ingress.

Abstract: A medical tube comprises a tail to connect an embedded wire to an electrical component. The tail may comprise a flattened portion and an exposed portion to facilitate attachment of the medical tube to an electrical component. The tail may comprise a second flattened portion. One or more wires, such as a heater wire or a sensor wire, may be embedded in the medical tube. The medical tube may comprise a connector that comprises a printed circuit board to which the one or more wires is attached. The connector may comprise features to support the printed circuit board, aid in assembly of the one or more wires to the connector, and protect electrical components against liquid ingress.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: A medical tube comprises a tail to connect an embedded wire to an electrical component. The tail may comprise a flattened portion and an exposed portion to facilitate attachment of the medical tube to an electrical component. The tail may comprise a second flattened portion. One or more wires, such as a heater wire or a sensor wire, may be embedded in the medical tube. The medical tube may comprise a connector that comprises a printed circuit board to which the one or more wires is attached. The connector may comprise features to support the printed circuit board, aid in assembly of the one or more wires to the connector, and protect electrical components against liquid ingress.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.