Patents by Inventor Thomas James KRELL, II

Thomas James KRELL, II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200002261
    Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 2, 2020
    Applicant: CAYMAN CHEMICAL COMPANY INCORPORATED
    Inventors: Kirk William Hering, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussien Mahmoud MAHMOUD
  • Patent number: 10450257
    Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: October 22, 2019
    Assignee: Cayman Chemical Company Incorporated
    Inventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
  • Publication number: 20180141889
    Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Application
    Filed: January 18, 2018
    Publication date: May 24, 2018
    Applicant: CAYMAN CHEMICAL COMPANY INCORPORATED
    Inventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
  • Patent number: 9908834
    Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: March 6, 2018
    Assignee: Cayman Chemical Company Incorporated
    Inventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
  • Publication number: 20170297995
    Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Application
    Filed: May 1, 2017
    Publication date: October 19, 2017
    Applicant: CAYMAM CHEMICAL COMPANY INCORPORATED
    Inventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
  • Publication number: 20150315114
    Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
    Type: Application
    Filed: December 6, 2013
    Publication date: November 5, 2015
    Inventors: Kirk Willam HERING, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussein Mahmoud MAHMOUD