Patents by Inventor Thomas Jan Boltje

Thomas Jan Boltje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • New fluorinated hexoses
    Publication number: 20230340002
    Abstract: The present invention relates to a new class of compounds based on a hexose featuring at least two 6-fluorides. The class is useful as inhibitors of 4,6-dehydratase enzymes. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying cancer, tumor metastasis, inflammation, infections, or genetic disorders.
    Type: Application
    Filed: September 9, 2021
    Publication date: October 26, 2023
    Applicant: Stichting Radboud Universiteit
    Inventors: Johan Franciscus Adrianus Pijnenborg, Thomas Jan Boltje, Emiel Rossing
  • Potent sialyltransferase inhibitors
    Patent number: 11639364
    Abstract: The present invention relates to a new class of sialyltransferase inhibitors. The class features a carbamate or similar moiety on the amine of a neuraminic acid derivative. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying bacterial infection, viral infection, cancer, a disorder of sialic acid metabolism, or an autoimmune disease.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 2, 2023
    Assignees: STICHTING RADBOUD UNIVERSITEIT, STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
    Inventors: Thomas Jan Boltje, Torben Heise, Johan Franciscus Adrianus Pijnenborg, Christian Büll, Gosse Jan Adema
  • New potent sialyltransferase inhibitors
    Publication number: 20210107931
    Abstract: The present invention relates to a new class of sialyltransferase inhibitors. The class features a carbamate or similar moiety on the amine of a neuraminic acid derivative. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying bacterial infection, viral infection, cancer, a disorder of sialic acid metabolism, or an autoimmune disease.
    Type: Application
    Filed: January 29, 2019
    Publication date: April 15, 2021
    Applicant: Stichting Katholieke Universiteit
    Inventors: Thomas Jan Boltje, Torben Heise, Johan Franciscus Adrianus Pijnenborg, Christian Büll, Gosse Jan Adema