Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

Abstract: Embodiments of a method for the preparation of an electrode assembly, include removing a population of negative electrode subunits from a negative electrode sheet, the negative electrode sheet comprising a negative electrode sheet edge margin and at least one negative electrode sheet weakened region that is internal to the negative electrode sheet edge margin, removing a population of separator layer subunits from a separator sheet, and removing a population of positive electrode subunits from a positive electrode sheet, the positive electrode sheet comprising a positive electrode edge margin and at least one positive electrode sheet weakened region that is internal to the positive electrode sheet edge margin, and stacking members of the negative electrode subunit population, the separator layer subunit population and the positive electrode subunit population in a stacking direction to form a stacked population of unit cells.

Abstract: A cyber-security analysis method uses machine learning (ML) technology to classify cyber-threat indicators, for example, as malicious or benign, by generating a threat score. The method includes receiving, at a compute device, a cyber-threat indicator (IUE) and associated verdicts from a set of sources. Augmenting the verdicts associated with the IUE with verdicts associated with at least one related indicator having a defined relationship with the IUE. The relationship between the IUE and the at least one related indicator can be operational, e g., based on an administrative domain, or functional, e.g., based on a protocol specification. The cyber-threat score is generated for the IUE based on the ML model and the combined verdicts of the IUE and the at least one related indicator.

Abstract: An embodiment includes a method to increase the efficiency of security checkpoint operations. A security checkpoint kiosk serves as a Relying Party System (RPS). The RPS establishes a secure local connection between the RPS and a User Mobile-Identification-Credential Device (UMD). The RPS sends a user information request to the UMD, via the secure local connection, seeking release of user information associated with a Mobile Identification Credential (MIC). The RPS obtains authentication of the user information received in response to the user information request. The RPS retrieves user travel information based on the user information. The RPS determines that the user travel information matches the user information. When the user travel information matches the user information, the RPS approves the user to proceed past the security checkpoint kiosk.

Abstract: A lead-acid battery is disclosed. The lead-acid storage battery has a container with a cover, the container including one or more compartments. One or more cell elements are provided in the one or more compartments. The one or more cell elements include a positive plate, the positive plate having a positive grid and a positive electrochemically active material on the positive grid; a negative plate, the negative plate having a negative grid and a negative electrochemically active material on the negative grid, wherein the negative electrochemically active material comprises barium sulfate and an organic expander; and a separator between the positive plate and the negative plate. Electrolyte is provided within the container. One or more terminal posts extend from the cover and are electrically coupled to the one or more cell elements.

Abstract: A heating, ventilating, and air conditioning (HVAC) system includes at least one indoor air quality monitor. The indoor air quality monitor is formed with an arrangement of chambers—intake chamber, low-flow chamber, and outlet chamber—such that a particulate sensor on an interior and another air quality sensor are neither overwhelmed nor underwhelmed by air flow to the sensors. The indoor air quality monitor may be arranged for attaching to a surface in a conditioned space for sampling air therein or may include a bypass chamber that fluidly couples to an HVAC duct.

Abstract: A controller is configured to operate a heating, ventilation, and air conditioning (HVAC) system based on a measurement of a detected quantity of particulate matter from an air quality sensor in relation to a threshold value.

Abstract: Disclosed herein, inter alia, are compositions and methods for targeting E3 ligases.

Abstract: A system for theming is disclosed. A transformer receives a plurality of sampled thought objects and a prompt from a theming computer. The prompt is designed to provide context data, format requirements, and instructions for theme assignment. The plurality of thought objects comprises text present in data from communication environments and the prompt requests the transformer to assign themes to each thought object. An object-theming transformer with a list of themes determines the probability score for mapping a thought object to a list of themes. When an associated probability score is above a threshold, the thought object is assigned to a known theme. In an embodiment, un-themed thought objects (not mapped to known themes) are provided to a topic identification transformer to generate theme names. The themes assigned and/or generated by the theming transformer and topic identification transformer are displayed on a graphical user interface.

Abstract: Described is an adhesive coating that can be applied, for example, to a surface of the insulation product. The adhesive coating includes between about 15-40% by weight of the adhesive coating of at least one of polystyrene-maleic anhydride (SMA) and polyacrylic acid (PAA), between about 15 and 50% by weight of the adhesive coating of a polyvinyl alcohol, between about 0.05% and 1.0% by weight of a homogenizer, and between about 20 and 40% by weight of the adhesive coating of a starch paste. The adhesive is activated with the application of liquid water.

Abstract: An axle assembly having a differential carrier, a drive pinion, a bearing assembly, and a preload nut. The drive pinion has a shaft that has a threaded portion. The bearing assembly rotatably supports the drive pinion on the differential carrier. The preload nut mates with the threaded portion and exerts a preload force on the bearing assembly.

Abstract: Three-dimensional (3D) memory structures and methods of formation of same are provided herein. In some embodiments, a 3D memory fabrication structure includes: a base silicon (Si) layer; a silicon germanium (SiGe) layer disposed above the base Si layer; and a doped silicon (Si) layer disposed on at least one side of the SiGe layer, wherein the doped Si layer contains a dopant that is at least one of carbon (C) or boron (B).

Abstract: A controller is configured to operate a heating, ventilation, and air conditioning (HVAC) system based on a first plurality of particulate matter measurements and a second plurality of particulate matter measurements. The controller is configured to determine an air filter efficiency for an air filter based on the received first plurality of particulate matter measurements and the received second plurality of particulate matter measurements. The controller is further configured to determine if a quantity of particulate matter in an airflow exceeds a first threshold value based on the received second plurality of particulate matter measurements. In response to determining that the quantity of particulate matter in the airflow does exceed the first threshold value, the controller is configured to transmit a notification indicating an action to inspect the air filter.

Abstract: The present application discloses novel cyclohexane dicarboxylate mixed esters of formula I: wherein R1, R2, and n are defined herein. The mixed esters are useful as plasticizers. The application also discloses resin compositions comprising the cyclohexane dicarboxylate mixed esters of formula I.

Abstract: A blended expander formula for use in the preparation of lead acid battery electrodes is disclosed. The mixture comprises fine particle barium sulfate, a first oxylignin, a second oxylignin, and a carbonaceous material. A method, a negative paste, and a negative electrode including the blended expander mixture are also disclosed. A lead-acid absorbent glass mat battery is further disclosed.

Abstract: A positioning device which includes a new and unique concave angulated device for at least one of, but not limited to, stretching, supporting, bracing, rehabilitating, positioning, massaging, kneading, scratching, or exercising a body of a user. The device's new concave angulated and more user friendly surface addresses the need for a more anatomically responsive body positioning device for achieving improved results relative to, among other things, the above uses. This device includes multiple embodiments, which also may comprise various possible configurations, that enable the device to also function as a fulcrum or lever and/or be capable of uniquely dispersing a load during the interaction between the user and the device.

Abstract: Embodiments of secondary batteries having electrode assemblies are provided. A secondary battery can comprise an electrode assembly having a stacked series of layers, the stacked series of layers having an offset between electrode and counter-electrode layers in a unit cell member of the stacked series. A set of constraints can be provided with a primary constraint system with first and second primary growth constraints separated from each other in a longitudinal direction, and connected by at least one primary connecting member, and a secondary constraint system comprises first and second secondary growth constraints separated in a second direction and connected by members of the stacked series of layers. The primary constraint system may at least partially restrain growth of the electrode assembly in the longitudinal direction, and the secondary constraint system may at least partially restrain growth in the second direction that is orthogonal to the longitudinal direction.

Abstract: A reader comprising: a panel; two antennae each associated with a respective race to transmit and/or receive information to/from an electronic animal tag in that respective race; and an electromagnetic shield to impede an antenna from transmitting and/or receiving information to/from an electronic animal tag not located in the respective race of that antenna; a system for reading electronic animal tags comprising: a plurality of readers each located at or near a wall of a respective plurality of races, wherein each reader is at least partially shielded by an electromagnetic shield; each reader being longitudinally offset with respect to at least one other reader in the plurality of readers; and methods of constructing and using a reader.

Abstract: The present invention provides a device with a pressure control system and methods for controlling the application of negative pressure to an external surface of an individual for creating and/or maintaining patency of the upper airway passage. The device is configured to fit under the chin of a subject at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The pressure control system contains control module elements that may include circuit board elements, digital output barometer elements, sensor elements, processing elements and memory elements to optimize device function and safety of the device through regulation of the flow rate of the air pump.

Abstract: The systems and/or processes described herein are configured to help an entity operating one or more facilities manage the scheduling and assignment of jobs. The systems and/or processes implement a loading service to manage the scheduling and assignment of jobs based on one or more factors including, but not limited to, a type of service or work to be performed on an item (e.g., an automobile), an initial estimated duration of time to perform the type of service or work, a revised estimated duration of time to perform the type of service or work (e.g., based on technician input), technician schedules, technician skills, technician skill level, and/or one or more labels assigned to a job. Consequently, the loading service is able to help, e.g., via the generation and output of graphical user interfaces, the entity balance the scheduling of appointments for jobs amongst technicians working at one or more facilities.