Abstract: There is provided a liquid or gel composition for generating hydrogen peroxide. The composition comprises enzyme that is able to convert a substrate to release hydrogen peroxide; substrate for the enzyme; and polymer. The composition does not comprise sufficient free water to allow the enzyme to convert the substrate, has a water activity (aw) of 0.7 or less, and/or comprises 5% or less, by weight of water. The composition may have droplets of supersaturated aqueous solution comprising the substrate which are suspended in the polymer. There may be greater than 70%, by weight, of the polymer in the composition. The composition may comprise less than 2%, by weight, non-aqueous solvent, and i) greater than 50%, by weight, of the polymer, and/or ii) less than 20%, by weight, of sugar.

Abstract: Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as emulsions or creams. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections.

Abstract: Compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, a substrate for the enzyme, and a solute in the form of a sugar or sugar derivative having a solubility of at least 100 g/100 g water at 20° C. and 1 atm. The compositions may not comprise sufficient free water to allow the enzyme to convert the substrate.

Abstract: Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a substrate to release hydrogen peroxide; and a substance that includes a substrate for the enzyme, wherein the first phase and the second phase are immiscible. The compositions may be formulated as colloids, suspensions or emulsions, especially as creams or sprays. Methods of making the compositions are described, as well as their use for the treatment of antimicrobial infections.