Abstract: The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous—as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration.

Abstract: A molded plastic applicator for cosmetics, such as a mascara brush, including an integral molded plastic panel that lies substantially in a mold plane when formed and is bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings, or projections such as bristles, are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and to be oriented substantially radially of the longitudinal axis in directions distributed around the axis when the panel is bent to surround the axis. A retainer holds the panel bent out of the plane in surrounding relation to the axis.

Abstract: A molded plastic applicator for cosmetics, such as a mascara brush, including an integral molded plastic panel that lies substantially in a mold plane when formed and is bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings, or projections such as bristles, are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and to be oriented substantially radially of the longitudinal axis in directions distributed around the axis when the panel is bent to surround the axis. A retainer holds the panel bent out of the plane in surrounding relation to the axis.

Abstract: A molded plastic applicator for cosmetics, such as a mascara brush, including an integral molded plastic panel that lies substantially in a mold plane when formed and is bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings, or projections such as bristles, are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and to be oriented substantially radially of the longitudinal axis in directions distributed around the axis when the panel is bent to surround the axis. A retainer holds the panel bent out of the plane in surrounding relation to the axis.

Abstract: A molded plastic applicator for cosmetics, such as a mascara brush, including an integral molded plastic panel that lies substantially in a mold plane when formed and is bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings, or projections such as bristles, are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and to be oriented substantially radially of the longitudinal axis in directions distributed around the axis when the panel is bent to surround the axis. A retainer holds the panel bent out of the plane in surrounding relation to the axis.

Abstract: A molded plastic applicator for cosmetics including a plastic panel lying substantially in a mold plane when formed and bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings or projections are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and oriented substantially radially of the longitudinal axis when the panel is bent to surround the axis. A retainer holds the panel, when bent, in surrounding relation to the axis. The panel may be formed as a plurality of free-ended limbs, radiating from a hub through which the longitudinal axis extends, and bent down around the axis.

Abstract: A cosmetic applicator for transporting and applying cosmetic material, including flocked applicators, a method for making applicators, and cosmetic dispensers including such applicators. The fibers of the flocking can vary in length, density, distribution and/or color.

Abstract: A molded plastic applicator for cosmetics, such as a mascara brush, including an integral molded plastic panel that lies substantially in a mold plane when formed and is bent out of the mold plane to surround an extended longitudinal axis when the applicator is assembled. A plurality of openings, or projections such as bristles, are formed in or on the panel so as to be oriented substantially in a common pull direction transverse to the mold plane when the panel lies in the mold plane and to be oriented substantially radially of the longitudinal axis in directions distributed around the axis when the panel is bent to surround the axis. A retainer holds the panel bent out of the plane in surrounding relation to the axis.

Abstract: A cosmetic applicator for transporting and applying cosmetic material, including flocked applicators, a method for making applicators, and cosmetic dispensers including such applicators. The fibers of the flocking can vary in length, density, distribution and/or color.

Abstract: Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.

Abstract: Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.