Abstract: A microplate device, and the manufacture thereof, for detecting biologic, metallic, organic or inorganic substances using Raman Spectroscopy or equivalent analytical methods. The microplate has an array of wells that have metal, metal oxide, or a combination thereof on bottoms and/or sides of the wells. These may be coated with a substrate of metals and/or oxides that may physically or chemically react with or bind with a target substance or with another molecule, protein, or aptomer that then binds itself to the target substance. The metal(s) and/or metal oxides may react physically or chemically with a solution in which the target substance resides, making the target substance easier to detect.

Abstract: A framework of copper oxide dendrites is formed on a copper substrate, and these are then coated or plated with silver, gold, or an equivalent metal to create metal-coated dendrites with nano-structures, favorably in range of 50 to 200 nanometers. The framework of metal-coated dendrites are well suited for use in surface-enhanced Raman spectroscopy and other practical applications.

Abstract: A framework of copper oxide dendrites is formed on a copper substrate, and these are then coated or plated with silver, gold, or an equivalent metal to create metal-coated dendrites with nano-structures, favorably in range of 50 to 200 nanometers. The framework of metal-coated dendrites are well suited for use in surface-enhanced Raman spectroscopy and other practical applications.