Patents by Inventor Thomas Joseph Sayers

Thomas Joseph Sayers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment
    Patent number: 10849912
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: December 1, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas Joseph Sayers, Alan David Brooks, Curtis J. Henrich, Poonam Tewary, James Brislin McMahon, Leslie Gunatilaka, Ya-Ming Xu, Kithsiri Wijeratne
  • METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF APOPTOSIS INDUCING LIGANDS IN CANCER TREATMENT
    Publication number: 20190046543
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.
    Type: Application
    Filed: February 9, 2017
    Publication date: February 14, 2019
    Applicants: The United States of America, as represented by the Secretary, Department of Healthe and Human, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas Joseph Sayers, Alan David Brooks, Curtis J. Henrich, Poonam Tewary, James Brislin McMahon, Leslie Gunatilaka, Ya-Ming Xu, Kithsiri Wijeratne
  • Method of sensitizing cancer cells to the cytotoxic effects of death receptor ligands in cancer treatment
    Patent number: 9238069
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: January 19, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Thomas Joseph Sayers, Nancy Lynn Booth, Curtis J. Henrich, Alan David Brooks, Kirk R. Gustafson, Karen L. Erickson
  • METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF DEATH RECEPTOR LIGANDS IN CANCER TREATMENT
    Publication number: 20130039883
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
    Type: Application
    Filed: December 16, 2010
    Publication date: February 14, 2013
    Applicant: THE UNITED STATES OF AMERICA
    Inventors: Thomas Joseph Sayers, Nancy Lynn Booth, Curtis J. Henrich, Alan David Brooks, Kirk R. Gustafson, Karen L. Erickson