Patents by Inventor Thomas Julius Borody

Thomas Julius Borody has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8772242
    Abstract: There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: July 8, 2014
    Inventor: Thomas Julius Borody
  • Patent number: 8679549
    Abstract: The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: March 25, 2014
    Inventors: Thomas Julius Borody, Sanjay Ramrakha, John Saxon, Anthony Wettstein
  • Publication number: 20130296314
    Abstract: In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.
    Type: Application
    Filed: December 13, 2011
    Publication date: November 7, 2013
    Inventors: Thomas Julius Borody, Sanjay Ramrakha, John Saxon, Antony Wettstein
  • Publication number: 20130273583
    Abstract: Detection of urease in gastric samples is achieved by using a composition comprising urea and an indicator. This composition can be provided in the form of a liquid or in a number of dry formats including a wafer, impregnated material, coated well or a tablet. The assay can be performed in described apparatus comprising a well which can be provided with a removable air-tight seal. In one optional form, the well may have a swaged rim for retaining a disc or ring inside the well and hinged plugs. This assay is useful for detecting H.
    Type: Application
    Filed: October 17, 2011
    Publication date: October 17, 2013
    Applicant: CENTRE FOR DIGESTIVE DISEASES PTY LIMITED
    Inventor: Thomas Julius Borody
  • Publication number: 20130266539
    Abstract: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. Coli, Gemmiger, Desulfamonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathoenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
    Type: Application
    Filed: June 5, 2013
    Publication date: October 10, 2013
    Inventor: Thomas Julius Borody
  • Publication number: 20130237488
    Abstract: The present disclosure provides improved compositions comprising rifabutin, clarithromycin, and clofazimine for use in the treatment of Inflammatory Bowel Diseases. In one instance, the compositions may comprise a formulation of rifabutin, clarithromycin, and clofazimine in a single dosage form, such as a capsule, tablet, etc., with one or more specific excipients.
    Type: Application
    Filed: December 20, 2012
    Publication date: September 12, 2013
    Applicant: RED HILL BIOPHARMA LTD.
    Inventors: Thomas Julius Borody, Patrick Gosselin
  • Publication number: 20130195804
    Abstract: In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection.
    Type: Application
    Filed: August 4, 2011
    Publication date: August 1, 2013
    Inventor: Thomas Julius Borody
  • Patent number: 8460648
    Abstract: The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E.Coli, Gemmiger, Desullomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathoenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: June 11, 2013
    Inventor: Thomas Julius Borody
  • Publication number: 20130102026
    Abstract: This invention relates to a culture medium, a kit containing the culture medium and to a method for detection of a parasite such as Dientamoeba fragilis and/or another parasite. The culture medium of the invention is bi-phasic and includes a solid phase containing an egg slope or agar slope and a liquid phase containing a serum and a peptone.
    Type: Application
    Filed: December 5, 2012
    Publication date: April 25, 2013
    Inventor: Thomas Julius BORODY
  • Patent number: 8372599
    Abstract: This invention relates to a culture medium, a kit containing the culture medium and to a method for detection of a parasite such as Dientamoeba fragilis and/or another parasite. The culture medium of the invention is bi-phasic and includes a solid phase containing an egg slope or agar slope; and a liquid phase including a serum and a peptone.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: February 12, 2013
    Inventor: Thomas Julius Borody
  • Patent number: 8343511
    Abstract: The present disclosure provides improved compositions comprising rifabutin, clarithromycin, and clofazimine for use in the treatment of Inflammatory Bowel Diseases. In one instance, the compositions may comprise a formulation of rifabutin, clarithromycin, and clofazimine in a single dosage form, such as a capsule, tablet, etc., with one or more specific excipients.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: January 1, 2013
    Assignee: Red Hill Biopharma Ltd.
    Inventors: Thomas Julius Borody, Patrick Gosselin
  • Publication number: 20120330111
    Abstract: A face mask (10) for a patient undergoing a sedated endoscopic procedure. The face mask (10) includes means (16, 17) to provide positive airway pressure to the nose, a bite block (18) with an opening therein (20) and a one-way valve (22). The one-way valve (22) has an open position, adapted to allow passage of an endoscopic device therethrough and into the opening (20), and a closed position substantially sealing the opening (20).
    Type: Application
    Filed: November 28, 2010
    Publication date: December 27, 2012
    Inventor: Thomas Julius Borody
  • Publication number: 20120282339
    Abstract: The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.
    Type: Application
    Filed: June 29, 2012
    Publication date: November 8, 2012
    Inventors: Thomas Julius BORODY, Sanjay RAMRAKHA, John SAXON, Anthony WETTSTEIN
  • Publication number: 20120207826
    Abstract: There is disclosed herein a composition for treating extracellular parasitic infections, the composition comprising one or more of the following combinations: at least one quinolone or fluoroquinolone together with at least one tetracycline, iodoquinol, an azole or imidazole; or at least two agents selected from the group consisting of iodoquinol, thiazolidones, tetracycline, nitroimidazoles, cotrimoxazole and diloxanide furoate.
    Type: Application
    Filed: October 22, 2010
    Publication date: August 16, 2012
    Inventors: Thomas Julius Borody, Soledad Carsula
  • Publication number: 20120202738
    Abstract: There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent.
    Type: Application
    Filed: October 22, 2010
    Publication date: August 9, 2012
    Inventor: Thomas Julius Borody
  • Publication number: 20120177650
    Abstract: A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent with such infections or for preventing or reducing the likelihood of enteric pathogen infections in animals at risk for developing such infections.
    Type: Application
    Filed: September 22, 2010
    Publication date: July 12, 2012
    Inventor: Thomas Julius Borody
  • Publication number: 20110223252
    Abstract: The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.
    Type: Application
    Filed: May 19, 2011
    Publication date: September 15, 2011
    Inventors: Thomas Julius BORODY, Sanjay RAMRAKHA, John SAXON, Antony WETTSTEIN
  • Patent number: 7993682
    Abstract: The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: August 9, 2011
    Inventors: Thomas Julius Borody, Sanjay Ramrakha, John Saxon, Antony Wettstein
  • Publication number: 20110059136
    Abstract: The present disclosure provides improved compositions comprising rifabutin, clarithromycin, and clofazimine for use in the treatment of Inflammatory Bowel Diseases. In one instance, the compositions may comprise a formulation of rifabutin, clarithromycin, and clofazimine in a single dosage form, such as a capsule, tablet, etc., with one or more specific excipients.
    Type: Application
    Filed: February 5, 2009
    Publication date: March 10, 2011
    Inventor: Thomas Julius Borody
  • Publication number: 20080286354
    Abstract: The invention relates to pharmaceutical compositions comprising at least one fibrate and at least one bile acid, and to methods for the treatment of hyperlipidaemia or elevated liver function tests in a patient by administering at least one fibrate and at least one bile acid to the patient.
    Type: Application
    Filed: June 3, 2008
    Publication date: November 20, 2008
    Inventor: THOMAS JULIUS BORODY