Abstract: This invention relates to a novel use of IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1b ligand-IL-1 receptor interaction, IL-1b antibodies or IL-1 receptor antibodies, e.g. IL-1b binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1b binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1b ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract: This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.

Abstract: A suspension device for a backrest for assisting an adjustment movement may have at least one spring element with a basic body and two end portions protruding from the basic body. The device also having a bearing element with a guide opening, and a counterbearing element with a receptacle. A first end portion is arranged in the receptacle and is mounted movably in a first direction relative to the counterbearing element. A second end portion may be arranged in the guide opening and may be mounted movably in a second direction relative to the bearing element. A backrest and a seat arrangement having the suspension device are also provided.

Abstract: Sensor arrangement for detecting slip between first and second clutch elements of a clutch includes: a magnetic field source generating an initial magnetic field; a first magnetic field influencing element connectable to or configured integrally with the first clutch element; a second magnetic field influencing element connectable to or configured integrally with the second clutch element; and a magnetic field sensor configured to measure a parameter characterizing a superimposed magnetic field. The magnetic field source, the first magnetic field influencing element and the second magnetic field influencing element are arranged such that the initial magnetic field of the magnetic field source from the first magnetic field influencing element and from the second magnetic field influencing element is converted into the superimposed magnetic field. An evaluation unit determines the slip of the clutch from the parameter and generates a signal characterizing a state of the clutch based on the slip.

Abstract: Surface supported quantum wells with a confined surface state capture and stably confine neutral atoms and molecules in a nanometer precise environment. Depending on the physico-chemical conditions in the capturing process, the degree of occupancy, the temperature of the solid substrate, and/or the history of external stimuli like electromagnetic field pulses, these atoms, molecules or clusters assume unique configurations. The atoms or molecules are able to remain coupled to the quantum-well specific electronic state in the confinement and as such exhibit local and delocalized quantum entanglement. The capturing potential arises from the superposition of Pauli repulsion between the captured object and the quantum well-specific confined electronic state. This occurs within on-surface atomic or supramolecular assemblies or surface supported coordination or covalent networks.

Abstract: The invention relates to an ultrasonic sensor (112) for use in a distance detection system (110) for a vehicle (111), wherein the ultrasonic sensor (112) is designed to be installed jointly with at least one other ultrasonic sensor (112), the ultrasonic sensor (112) has a first input (114) for connection to a supply lead (116), the ultrasonic sensor (112) has a second input (118) for connection to a ground potential (120) of the vehicle (111), and the ultrasonic sensor (112) has an output (122) for connection to the supply lead (116), wherein the ultrasonic sensor (112) is designed to receive a data signal modulated on the supply lead (116) via the first input (114) and to modulate a data signal onto the supply lead (116) via the output (122).

Abstract: This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.

Abstract: A suspension device for a backrest for assisting an adjustment movement may have at least one spring element with a basic body and two end portions protruding from the basic body. The device also having a bearing element with a guide opening, and a counterbearing element with a receptacle. A first end portion is arranged in the receptacle and is mounted movably in a first direction relative to the counterbearing element. A second end portion may be arranged in the guide opening and may be mounted movably in a second direction relative to the bearing element. A backrest and a seat arrangement having the suspension device are also provided.

Abstract: Surface supported quantum wells with a confined surface state capture and stably confine neutral atoms and molecules in a nanometer precise environment. Depending on the physico-chemical conditions in the capturing process, the degree of occupancy, the temperature of the solid substrate, and/or the history of external stimuli like electromagnetic field pulses, these atoms, molecules or clusters assume unique configurations. The atoms or molecules are able to remain coupled to the quantum-well specific electronic state in the confinement and as such exhibit local and delocalized quantum entanglement. The capturing potential arises from the superposition of Pauli repulsion between the captured object and the quantum well-specific confined electronic state. This occurs within on-surface atomic or supramolecular assemblies or surface supported coordination or covalent networks.

Abstract: The present invention relates to a measuring device with a magnetic field sensor for detecting at least one operating parameter of an agricultural joint shaft for torque transmission between a power take-off shaft of a towing vehicle and a transmission of an agricultural appliance, which includes at least one journal cross, to the opposing journals of which a shaft body is connected, and a protective tube rotatably accommodating the shaft body therein, wherein the magnetic field sensor is adapted to measure a magnetic field emanating from the bare shaft body of the joint shaft.

Abstract: A hybrid drive device includes an internal combustion engine, an electric machine and an impulse start module which comprises two clutches and a flywheel mass. A method for operating the hybrid device includes opening the first clutch of the impulse-start module and establishing a start-up requirement for the internal-combustion engine. The method also includes closing the first clutch with the second clutch in an open or closed position for a start of the internal-combustion engine.

Abstract: A hybrid drive transmission unit for a vehicle with an internal combustion engine and an electric motor for the drive part, includes a power-split transmission with sub-transmissions and a torsion-damping unit with a gyrating mass interconnected between the internal combustion engine and the power-split transmission. A clutch is interconnected between the internal combustion engine and the torsion-damping unit, by which the internal combustion engine can be activated, switching from the electromotive operating mode.

Abstract: The invention relates to methods for treating autoimmune inner ear disease (AIED). In particular, the invention relates to treating AIED with humanized anti-IL-1? antibodies or fragments thereof, especially monovalent, highly potent anti-IL-1? antibody fragments. The invention further relates to antibodies, compositions and kits for use in the methods of the invention.

Abstract: The invention relates to an ultrasonic sensor (112) for use in a distance detection system (110) for a vehicle (111), wherein the ultrasonic sensor (112) is designed to be installed jointly with at least one other ultrasonic sensor (112), the ultrasonic sensor (112) has a first input (114) for connection to a supply lead (116), the ultrasonic sensor (112) has a second input (118) for connection to a ground potential (120) of the vehicle (111), and the ultrasonic sensor (112) has an output (122) for connection to the supply lead (116), wherein the ultrasonic sensor (112) is designed to receive a data signal modulated on the supply lead (116) via the first input (114) and to modulate a data signal onto the supply lead (116) via the output (122).

Abstract: This invention relates to a novel use of IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1b ligand-IL-1 receptor interaction, IL-1b antibodies or IL-1 receptor antibodies, e.g. IL-1b binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1b binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1b ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract: This invention relates to methods employing IL-1 beta-ligand/IL-1 receptor disrupting compounds, such as IL-1 beta antibodies or IL-1 receptor antibodies, in the treatment and/or prevention of auto-inflammatory syndromes in mammals, particularly humans.

Abstract: This invention relates to a novel use of IL-1?-ligand/IL-1 receptor disrupting compounds (herein referred to as “IL-1beta Compounds”); such as small molecular compounds disrupting IL-1b ligand-IL-1 receptor interaction, IL-1b antibodies or IL-1 receptor antibodies, e.g. IL-1b binding molecules described herein, e.g. antibodies disclosed herein, e.g. IL-1b binding compounds or IL-1 receptor binding compounds, and/or RNA compounds decreasing either IL-1b ligands or IL-1 receptor protein levels, in the treatment and/or prevention of auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome and to methods of treating and/or preventing auto-inflammatory syndromes, e.g. Juvenile rheumatoid arthritis or adult rheumatoid arthritis syndrome, in mammals, particularly humans.

Abstract: A drive apparatus for a hybrid vehicle has an internal combustion engine, which has a crankshaft for outputting a drive power, and a torsional vibration reduction device, which is designed to reduce torsional vibrations and to transfer drive power from the crankshaft in the direction of a drivable wheel of the motor vehicle. A clutch device has a clutch input side, a clutch output side, a form-fit clutch and a frictional clutch. The torque transfer from the clutch input side to the clutch output side and thus from the crankshaft to the drivable wheel can be selectively produced, wherein the torque transition from the clutch input side to the clutch output side is enabled as soon as at least one of the two clutches is closed. The torsional vibration reduction device is arranged after the clutch device, relative to the torque transmission from the crankshaft in the direction of the drivable wheel.

Abstract: A drive system for a hybrid vehicle and a method of operation of the drive system are provided. The drive system includes an internal combustion engine having a shaft, a vehicle transmission having a transmission input shaft and an output shaft, a transmission clutch between the transmission input and output shafts, an inertia-mass drive unit arranged between the internal combustion engine shaft and the transmission input shaft, a first clutch between the internal combustion engine shaft and inertia-mass drive unit and a second clutch between the inertia-mass drive unit and the transmission input shaft; and an electrical machine torque-transmittingly connected to the transmission input shaft. The inertia-mass drive unit may include rotational oscillation reduction device.

Abstract: A hybrid drive device includes an internal combustion engine, an electric machine and an impulse start module which comprises two clutches and a flywheel mass. A method for operating the hybrid device includes opening the first clutch of the impulse-start module and establishing a start-up requirement for the internal-combustion engine. The method also includes closing the first clutch with the second clutch in an open or closed position for a start of the internal-combustion engine.