Abstract: Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: Radically polymerizable dental material, which contains a combination of a thiourea derivative and a hydroperoxide according to the following Formula (I) as initiator system for the radical polymerization:

Abstract: A method includes receiving radiation with a hybrid data detection system of an imaging system. The hybrid data detection system includes a hybrid data detector array with a set of spectral detectors and a set of integrating detectors that are arranged along a transverse axis of an examination region. The method further includes generating a set of truncated spectral projections with the first set of spectral detectors. The method further includes estimating a set of spectral projections for the integrating detectors. The method further includes combining the set of truncated spectral projections and the estimated set of spectral projections. The method further includes estimating a set of spectral projections based on the combined set to produce a complete set of spectral projections. The method further includes processing the complete set of spectral projections to generate volumetric image data.

Abstract: The present invention relates to X-ray differential phase-contrast imaging, in particular to a deflection device for X-ray differential phase-contrast imaging. In order to provide differential phase-contrast imaging with improved dose efficiency, a deflection device (28) for X-ray differential phase-contrast imaging is provided, comprising a deflection structure (41) with a first plurality (44) of first areas (46), and a second plurality (48) of second areas (50). The first areas are provided to change the phase and/or amplitude of an X-ray radiation; and wherein the second areas are X-ray transparent. The first and second areas are arranged periodically such that, in the cross section, the deflection structure is provided with a profile arranged such that the second areas are provided in form of groove-like recesses (54) formed between first areas provided as projections (56). The adjacent projections form respective side surfaces (58) partly enclosing the respective recess arranged in between.

Abstract: The present invention relates to acquiring reference scan data for X-ray phase-contrast imaging and/or X-ray dark-field imaging. Therefore an X-ray detector (26) is arranged opposite an X-ray source (12) across an examination region (30) with a grating arrangement (18) arranged between the X-ray source (12) and the X-ray detector (26). During an imaging operation without an object in the examination region (30) the grating arrangement (18) is moved in a scanning motion to a number of different positions (a) relative to the X-ray detector (26) whilst the X-ray detector (26) remains stationary relative to the examination region (30) such that in the scanning motion a series of fringe patterns is detected by the X-ray detector (26). The scanning motion is repeated for a different series of fringe patterns. This allows acquiring reference scan data required for calibration of an X-ray imaging device (10??) with less scanning motions.

Abstract: An image processing system and related method. The system comprises an input interface (IN) for receiving dark-field image data obtained from imaging of an object (OB) with an X-ray imaging apparatus (XI). A corrector module (CM) of the system (IPS) is configured to perform a correction operation to correct said dark-field image data for Compton scatter to obtain Compton-Scatter corrected image data. The so Compton scatter corrected image data is output by an output interface (OUT) of the system.

Abstract: A method for operating translation look-aside buffers, TLBs, in a multiprocessor system. A purge request is received for purging one or more entries in the TLB. When the thread doesn't require access to the entries to be purged the execution of the purge request at the TLB may start. When an address translation request is rejected due to the TLB purge, a suspension time window may be set. During the suspension time window, the execution of the purge is suspended and address translation requests of the thread are executed. After the suspension window is ended the purge execution may be resumed. When the thread requires access to the entries to be purged, it may be blocked for preventing the thread sending address translation requests to the TLB and upon ending the purge request execution, the thread may be unblocked and the address translation requests may be executed.

Abstract: A device and method for the controlled processing of at least one workpiece (1), comprising a workpiece carrier (2) on which at least one workpiece receptacle (2.1) is present remote from a rotary shaft (2.0), at least one processing unit (3) and at least one inspection unit (4), which are offset relative to the rotary shaft (2.0) by an angular distance (?n) from one another, are each arranged so that they can be adjusted and moved in a translational manner radially with respect to the rotary shaft (2.0), so that a processing beam (E) and an inspection beam (P), offset relative to one another by the angular distance (?n), describe the same spiral-shaped movement path (S) relative to the workpiece carrier (2), and the inspection results derived at an inspection point (PP) are used to control process parameters in order to change the effect of the processing beam (E).

Abstract: The invention relates to beam hardening correction in X-ray Dark-Field imaging of a subject including a first material and a second material, the first and second material having different beam hardening properties. As the X-ray imaging data includes information on the internal structure of the imaged subject, such information may be used, together with appropriate calibration data to identify the beam hardening contributions occurring in the imaged area of the subject, so to allow for a correction of artifacts due to beam hardening in X-ray Dark-Field imaging.

Abstract: A method for identifying occupant-specific settings for a vehicle comprises detecting a vehicle occupant; collecting biometric occupant data of the detected vehicle occupant; assembling a descriptor based on at least part of the collected occupant data; storing the descriptor in a database; and updating a cluster of descriptors in the database based on the assembled descriptor, wherein descriptors grouped in the cluster are close to each other, and wherein the cluster corresponds to the detected vehicle occupant. Based on the cluster and assembled descriptor can be assigned to the cluster, and vehicle setting data can be calculated that has been stored in association with the cluster. The vehicle setting data corresponds to occupant-specific settings for the vehicle. A vehicle comprises a system capable of performing such method.

Abstract: The invention relates to an analyzing grid for phase contrast imaging and/or dark-field imaging, a detector arrangement for phase contrast imaging and/or dark-field imaging comprising such analyzing grid, an X-ray imaging system comprising such detector arrangement, a method for manufacturing such analyzing grid, a computer program element for controlling such analyzing grid or detector arrangement for performing such method and a computer readable medium having stored such computer program element. The analyzing grid comprises a number of X-ray converting gratings. The X-ray converting gratings are configured to convert incident X-ray radiation into light or charge. The number of X-ray converting gratings comprises at least a first X-ray converting grating and a second X-ray converting grating.

Abstract: An address translation facility is provided for multiple virtualization levels, where a guest virtual address may be translated to a guest non-virtual address, the guest non-virtual address corresponding without translation to a host virtual address, and the host virtual address may be translated to a host non-virtual address, where translation within a virtualization level may be specified as a sequence of accesses to address translation tables. The address translation facility may include a first translation engine and a second translation engine, where the first and second translation engines each have capacity to perform address translation within a single virtualization level of the multiple virtualization levels.

Abstract: An address translation facility is provided for multiple virtualization levels, where a guest virtual address may be translated to a guest non-virtual address, the guest non-virtual address corresponding without translation to a host virtual address, and the host virtual address may be translated to a host non-virtual address, where translation within a virtualization level may be specified as a sequence of accesses to address translation tables. The address translation facility may include a first translation engine and a second translation engine, where the first and second translation engines each have capacity to perform address translation within a single virtualization level of the multiple virtualization levels.

Abstract: An address translation facility is provided for multiple virtualization levels, where a guest virtual address may be translated to a guest non-virtual address, the guest non-virtual address corresponding without translation to a host virtual address, and the host virtual address may be translated to a host non-virtual address, where translation within a virtualization level may be specified as a sequence of accesses to address translation tables. The address translation facility may include a first translation engine and a second translation engine, where the first and second translation engines each have capacity to perform address translation within a single virtualization level of the multiple virtualization levels.

Abstract: The invention relates to a subject support device (1) to be used in a projection data acquisition apparatus (2) for acquiring projection data of a subject (3). The subject support device comprises a support component (4) providing a support surface (5) for supporting the subject while acquiring the projection data, a diffraction grating (6) for diffracting x-rays, and a moving unit (7, 8) for moving the support component and the diffraction grating relative to each other. This relative movement can allow for a movement of the support component such that the subject is moved through x-rays (16) for determining projection data of different parts of the subject, while the diffraction grating can still be traversed by the x-rays. These projection data can be used for generating a relatively large phase-contrast and/or dark-field projection image.

Abstract: An image processing system comprising: an input port (IN) for receiving two input images acquired of an object. Respective contrast in said images encodes information on different physical properties of the object. The images being converted from a signal detected at a detector (D) of an imaging apparatus (IM). A differentiator of the image processing system forms respective differences from pairs of image points from the respective input images. An edge evaluator (EV) computes, based on said differences, an edge score for at least one of said pairs of image points. The score is based on a measure that represents or is derivable from a conditional noise likelihood function. The likelihood function is based on a probability density that models noise for said signal. Said score is output through an output port (OUT).

Abstract: Radiation source and detector arrangement for a differential phase contrast CT scanner, in which the detector tiles are placed asymmetrically such that direct rays, which hit gaps between tiles are sampled by tile centers for the complementary rays. This may provide for good image quality without any approximate processing.

Abstract: An imaging system (1400) includes a first and a second focal spot (1410I and 1410N), a first pre-patient radiation beam filter (1416) disposed between the first focal spot and the examination region and having a first profile and a second pre-patient radiation beam filter (1416N) disposed between the second focal spot and the examination region and having a second profile, and a source controller (1412) that controls an operation of the focal spots by modulating the operation during a scan based on at least one of an angular position of focal spots, a shape of a region of interest of subject or object being scanned, or based on a change in size between two adjacent regions of the subject or object being scanned.

Abstract: An imaging system includes radiation source that emits radiation that traverses an examination region and a portion of a subject therein and a detector array that detects radiation that traverses the examination region and the portion of the subject therein and generates a signal indicative thereof. A volume scan parameter recommender recommends at least one spectral scan parameter value for a volume scan of the portion of the subject based on a spectral decomposition of first and second 2D projections acquired by the radiation source and detector array. The first and second 2D projections have different spectral characteristics. A console employs the recommended at least one spectral scan parameter value to perform the volume scan of the portion of the subject.

Abstract: A method for delivering antimicrobial compounds to a locus in a controlled manner by adding to the locus a compound having formula (I) wherein X is O or NH; R is an acrylic polymer, a saturated polyester, an alkyd resin, a polyether or a polycarbonate and R optionally has additional XC(O)NHCHR?R? substituents; R? is hydroxyl or NHC(O)XR; and R? is an organic substituent group having from one to twenty carbon atoms and which optionally has additional CHR?NHC(O)XR substituents.