Patents by Inventor Thomas K. Schaaf

Thomas K. Schaaf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins
    Patent number: 4455421
    Abstract: 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: June 19, 1984
    Assignee: Pfizer Inc.
    Inventors: Jasjit S. Bindra, James F. Eggler, Michael R. Johnson, Thomas K. Schaaf
  • 15-Substituted-.omega.-pentanorprostaglandin derivatives
    Patent number: 4404372
    Abstract: 15-Substituted-.omega.-pentanorprostaglandin C-1 tetrazoles, imides and sulfonimides.Their use as anti-secretory agents or as agents for the control of fertility.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: September 13, 1983
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Thomas K. Schaaf, Hans-Jurgen E. Hess
  • 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins
    Patent number: 4365077
    Abstract: 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: February 22, 1979
    Date of Patent: December 21, 1982
    Assignee: Pfizer Inc.
    Inventors: Jasjit S. Bindra, James F. Eggler, Michael R. Johnson, Thomas K. Schaaf
  • 2-Descarboxy-2-(tetrazol-5-yl)-16,16-dimethyl-17-( 2-furyl)-.omega.-trisnorprostaglandin E.sub.2
    Patent number: 4342868
    Abstract: 15-Substituted-.omega.-pentanorprostaglandin C-1 tetrazoles, imides and sulfonimides.Their use as anti-secretory agents or as agents for the control of fertility.
    Type: Grant
    Filed: April 1, 1981
    Date of Patent: August 3, 1982
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Thomas K. Schaaf, Hans-Jurgen E. Hess
  • Sulfonyl prostaglandin carboxamide derivatives
    Patent number: 4292444
    Abstract: The synthetic prostaglandin derivatives have a C-1 alkylsulfonylcarboxamide group, a trans C-2, C-3 double bond or cis C-4, C-5 double bond and a C-16 aryloxy group and are antiulcer or antifertility agents.
    Type: Grant
    Filed: February 8, 1980
    Date of Patent: September 29, 1981
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Thomas K. Schaaf
  • 15-Substituted-omega-pentanorprostaglandins
    Patent number: 4243595
    Abstract: The 15 aryl substituted-.omega.-pentanorprostaglandins and various intermediates empolyed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: July 15, 1976
    Date of Patent: January 6, 1981
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Michael R. Johnson, Jasjit S. Bindra, Thomas K. Schaaf
  • 15-Sulfonamidoprostaglandin derivatives
    Patent number: 4232173
    Abstract: Synthetic prostaglandin E compounds having carboxylic acid, ester, tetrazol, sulfonamide or imide substitutions at C-1, a methanesulfonamido group replacing the C-15 hydroxy and an aryloxy group at C-16 are disclosed. They exhibit antisecretory biological activity.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: November 4, 1980
    Assignee: Pfizer Inc.
    Inventors: Thomas K. Schaaf, James F. Eggler
  • Intermediates for synthesis of precursors for prostaglandins
    Patent number: 4214099
    Abstract: A new synthesis of key prostaglandin precursors and intermediates employed in their preparation. The novel synthetic sequence of this invention is shorter and more efficient than those previously employed to prepare to key intermediate.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: July 22, 1980
    Assignee: Pfizer Inc.
    Inventors: Elias J. Corey, Jasjit S. Bindra, Thomas K. Schaaf
  • 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins
    Patent number: 4157341
    Abstract: 11-Desoxy-16-aryloxy-.omega.-tetranorprostaglandins are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: November 9, 1977
    Date of Patent: June 5, 1979
    Assignee: Pfizer Inc.
    Inventors: Jasjit S. Bindra, James F. Eggler, Michael R. Johnson, Thomas K. Schaaf
  • 11-Desoxy-15-substituted-.omega.-pentanor prostaglandins
    Patent number: 4154949
    Abstract: 11-DESOXY-15-SUBSTITUTED-.omega.-PENTANORPROSTAGLANDINS AND VARIOUS INTERMEDIATES EMPLOYED IN THEIR PREPARATION. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: January 31, 1977
    Date of Patent: May 15, 1979
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Thomas K. Schaaf, Jasjit S. Bindra, Hans-Jurgen E. Hess, James F. Eggler
  • 15-Substituted-.omega.-pentanorprostaglandins
    Patent number: 4152527
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: December 27, 1973
    Date of Patent: May 1, 1979
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Thomas K. Schaaf
  • 15-Substituted-.omega.-pentanorprostaglandins
    Patent number: 4143051
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: March 6, 1979
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Michael R. Johnson, Jasjit S. Bindra, Thomas K. Schaaf
  • Process for preparing a lactone
    Patent number: 4122093
    Abstract: A new synthesis of key prostaglandin precursors and intermediates employed in their preparation. The novel synthetic sequence of this invention is shorter and more efficient than those previously employed to prepare to key intermediate.
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: October 24, 1978
    Assignee: Pfizer Inc.
    Inventors: Elias J. Corey, Jasjit S. Bindra, Thomas K. Schaaf
  • 15-Substituted-.omega.-pentanorprostaglandins
    Patent number: 4113723
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: September 12, 1978
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Michael R. Johnson, Jasjit S. Bindra, Thomas K. Schaaf
  • 15-Substituted-.omega.-pentanorprostaglandins
    Patent number: 4102894
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: July 15, 1976
    Date of Patent: July 25, 1978
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Michael R. Johnson, Jasjit S. Bindra, Thomas K. Schaaf
  • Furyl-2-oxo-alkanephosphonates
    Patent number: 4080368
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: April 21, 1977
    Date of Patent: March 21, 1978
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Michael R. Johnson, Jasjit S. Bindra, Thomas K. Schaaf
  • Dimethyl 2-oxo-6-cyanohexyl-phosphonate
    Patent number: 4078021
    Abstract: The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparation of the bronchodilatory agents of this invention.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: March 7, 1978
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Thomas K. Schaaf
  • Cyanoprostaglandins
    Patent number: 4074044
    Abstract: The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparation of the bronchodilatory agents of this invention.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: February 14, 1978
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Thomas K. Schaaf
  • 5-(2-Carboxythiophen-5-y l)-16-aryloxy-.alpha.-tetranor-.omega.-tetranorprostaglandins
    Patent number: 4065472
    Abstract: 5-(2-Carboxythiophen-5-yl)-16-aryloxy-.alpha.-tetranor-.omega.-tetranorpros taglandins and intermediates useful in their preparation are disclosed. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins but they exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: September 29, 1975
    Date of Patent: December 27, 1977
    Assignee: Pfizer Inc.
    Inventors: Thomas K. Schaaf, Jasjit Singh Bindra
  • Cyanoprostaglandins
    Patent number: 4045465
    Abstract: The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparations of the bronchodilatory agents of this invention.
    Type: Grant
    Filed: August 6, 1976
    Date of Patent: August 30, 1977
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Thomas K. Schaaf