Abstract: A pharmaceutical care practitioner has a n ongoing relationship with a patient in a series of encounters. The practitioner generates an assessment, including demographics of the patient, resulting in a set of indications for pharmacotherapy. The practitioner evaluates medications for appropriateness, effectiveness, safety, and compliance, and recommends or selects medications (including dosage, duration, frequency, etc.) for each indication in a care plan. The practitioner evaluates outcomes from the medications. Items from the assessment, plan, or outcomes are coded as searchable terms in a patient database employed by the practitioner for generating the care plan. The patient database may be consolidated among many different practitioners for greater statistical power. Agreements between practitioners and third-party providers may permit practitioners to override or allow actions not normally permitted by patients' plans, such as drug substitution, dosage adjustment, or choice of source.