Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: There is presented a method of measuring one or more potential differences being indicative of one or more concentrations of one or more analyte ions in a sample, such as being a liquid whole blood sample, said method comprising, measuring with a reference ion measurement setup a parameter indicative of a concentration of a reference ion in the sample wherein the reference ion measurement setup is different from an electroanalytical measurement setup, measuring with an analyte ion measurement setup one or more potential differences directly or indirectly between each of one or more, optionally solid-state, working electrodes with each of said, optionally solid-state, working electrodes comprising an ion-selective electrode which is selective for an analyte ion, and an, optionally solid state, reference electrode which is selective for the reference ion wherein the analyte ion measurement setup is an electroanalytical setup. There is additionally presented an apparatus and use of said apparatus.

Abstract: There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each

Abstract: A system (10) for determining a refractive index of a sample fluid or a concentration of a component in the sample fluid comprises a transparent sensing element (12) with a plurality of pores (122) for receiving a fluid. The pores reflect or scatter radiation emitted by a radiation emitter (14) of the system differently depending on the refractive index of the fluid. The system comprises one or more detectors (16) for detecting the reflected and/or scattered radiation. The refractive index of the sample fluid is determined based on the detected scattered and/or reflected radiation when the sample fluid is fed into the pores, the corresponding detected scattered and/or reflected radiation when first and second calibration fluids having predetermined refractive indices and predetermined absorptions at at least two wavelengths are fed into the pores, said predetermined refractive indices and said predetermined absorptions.

Abstract: There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (I I) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each

Abstract: The present invention relates a porous membrane sensor element for the detection of an analyte in a complex fluid sample.

Abstract: There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically co

Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: The invention relates to a porous optical fiber for the detection of an analyte in a fluid by optical probing. The optical fiber has a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction. The optical fiber comprises a core adapted for supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions. The optical fiber further comprises pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores.

Abstract: The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.

Abstract: The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space.

Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the method comprising: determining sensitivities of the device for each of two or more calibration solutions, wherein each calibration solution has a different amount of enzyme modulator; determining a degree of modulation for each of the two or more calibration solutions; determining a degree of modulation for a sample to be measured; and calculating the sensitivity of the device for the sample, wherein said calculating comprises modifying the sensitivity of one of the two or more calibration solutions by a function comprising the determined degrees of modulation.

Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.

Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.

Abstract: Sensor for the optical detection of free hemoglobin (96) in a whole blood sample (99), the sensor comprising a translucent slab (2) with a front side (3) and a back side (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a whole blood sample (99); a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer (5) from the translucent slab (2); an optical probing device comprising a light source (10) and a detector (20), wherein the light source (10) is adapted to illuminate at least pores in the translucent slab, wherein the detector (20) is arranged to receive light (21) emerging from the pores (6) in response to an illumination (11) by the light source (10), and wherein the detector (20) is adapted to generate a signal representative of the detected light.

Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.

Abstract: The present invention relates to methods for analyzing at least one blood parameter in a whole blood sample of a patient, wherein the in vitro hemolysis of a whole blood sample is determined. The present invention also relates to a corresponding analysis apparatus, a system for analysing a whole blood sample and a computer program element for controlling the analysis apparatus as well as a computer readable medium storing the computer program element. A method is provided for differentiating the contributions from in-vivo hemolysis and in-vitro hemolysis of an overall hemolysis level determined for the whole blood sample. Blood parameters like potassium or lactate dehydrogenase can then be corrected for hemolytic interference factors.

Abstract: A sensor element (101) for detecting an analyte in a fluid sample by optical probing comprises a translucent membrane (110) with a front side (111) defining a sensor surface for contacting a fluid sample, and a back side (112) facing away from the front side (111). The sensor element (101) has a reflective layer (114) at the front side (111) of the translucent membrane (110). An optical input port (120) is connected to the back side (112) of the translucent membrane (110) for feeding probing light to the translucent membrane (110) through the back side (112). An optical output port (130) is connected to the back side (112) of the translucent membrane (110) for collecting an optical response from the translucent membrane (110) through the backside (112). The sensor element further comprises an optical constriction element (140) with a screen element (141) arranged between the input port (120) and the output port (130), thereby optically separating the output port (130) from the input port (140).

Abstract: Sensor for the optical detection of free hemoglobin (96) in a whole blood sample (99), the sensor comprising a translucent slab (2) with a front side (3) and a back side (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a whole blood sample (99); a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer (5) from the translucent slab (2); an optical probing device comprising a light source (10) and a detector (20), wherein the light source (10) is adapted to illuminate at least pores in the translucent slab, wherein the detector (20) is arranged to receive light (21) emerging from the pores (6) in response to an illumination (11) by the light source (10), and wherein the detector (20) is adapted to generate a signal representative of the detected light.