Abstract: The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

Abstract: A housing having a first housing end and a second housing end, a substantially cylindrical work chamber formed in the housing, a piston which is arranged in the work chamber so as to be displaceable and which divides the work chamber into a first work space near the first housing end and a second work space near the second housing end, a piston rod which is arranged at one side of the piston and which projects through the first work space and is guided out of the work chamber in a sealed manner at the first housing end through a guiding and sealing device, and a valve chamber which is formed in the housing parallel to the work chamber and in which a first valve assembly and a second valve assembly are arranged. The work chamber is always completely filled with a liquid medium and the valve chamber is at least partially filled with a liquid medium.

Abstract: A continuously blockable locking device with a cylindrical housing forming a work chamber, a closed first end and a second end located opposite from the closed end, a piston rod which is guided out of the housing in a sealed manner through the second end so as to be arranged coaxial to the center longitudinal axis by means of a guiding and sealing device, a piston which is arranged at the end of the piston rod situated in the housing and which divides the work chamber into a first work space, through which the piston rod extends, and a second work space, and a housing which is connected to, or can be connected to, the housing and which forms a valve chamber, a first valve assembly and a second valve assembly being arranged therein. The work chamber is always completely filled with a liquid medium and the valve chamber is at least partially filled with a liquid medium.

Abstract: The present invention relates to a method for producing a structure modeled on a biological tissue. The invention also relates to a structure which can be produced using the method according to the invention. According to an embodiment of the invention, a precursor of a biopolymer is locally irradiated with electromagnetic radiation in a targeted manner, wherein the irradiation, in particular the selection of the areas to be irradiated, is effected according to data which describe a structural construction at least components of the extracellular matrix of the biological tissue. In this case, the electromagnetic radiation is such that two-photon or multi-photon absorption takes place in the irradiated areas of the precursor and results in the precursor being polymerized to form the biopolymer in the irradiated areas, with the result being that the precursor is at least partially solidified there.

Abstract: A process for detecting nucleic acids, having the following steps: providing at least one nanoparticle that is functionalised for the nucleic acid to be detected by means of at least one oligonucleotide that is bound to it and that is able to hybridize with at least one segment of a nucleic acid to be detected; bringing the functionalised nanoparticle into contact with a sample in which the nucleic acid is to be detected; and measuring a property that provides information about the degree of hybridization of the at least one oligonucleotide with the nucleic acid to be detected. In addition, the process includes the step of exciting the nanoparticles to generate heat, for example by means of a photothermal effect. The invention is suitable, in particular, for high-throughput DNA analysis.

Abstract: A continuously blockable locking device with a cylindrical housing forming a work chamber, a closed first end and a second end located opposite from the closed end, a piston rod which is guided out of the housing in a sealed manner through the second end so as to be arranged coaxial to the center longitudinal axis by means of a guiding and sealing device, a piston which is arranged at the end of the piston rod situated in the housing and which divides the work chamber into a first work space, through which the piston rod extends, and a second work space, and a housing which is connected to, or can be connected to, the housing and which forms a valve chamber, a first valve assembly and a second valve assembly being arranged therein. The work chamber is always completely filled with a liquid medium and the valve chamber is at least partially filled with a liquid medium.

Abstract: A composition of resonant passive metal-dielectric elements with gain medium results in a meta-material with an effective negative refractive index and compensated losses. To compensate for losses, additional energy is supplied using the stimulated emission from active elements made of a gain material. The overall objective is to overcome the fundamental threshold in resolution for conventional optical imaging limited to about a half-wavelength of incident light. The negative index material with compensated losses (NIMCOL) can be used in NIM-based optical imaging and sensing devices with enhanced sub-wavelength resolution. A lasing device based on overcompensating for the loss in NIM structures is disclosed as well.