Abstract: An arrangement for dispensing a fluid comprises a fluid cartridge comprising a casing for accommodating the fluid and a fluid dispensing unit configured for generating particles upon feeding the fluid in the casing with pressurized medium. The arrangement further comprises a dispenser device comprising a cartridge accommodation unit configured for accommodating the fluid cartridge and a pressure feed unit configured for feeding the fluid in a casing of the fluid cartridge with a pressurized medium upon accommodating the fluid cartridge in the cartridge accommodation unit to thereby generate the particles upon feeding the fluid in the casing with the pressurized medium.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for wound healing preferably in diabetic patients.

Abstract: A clamping tool is provided which includes a base, a clamping arm articulated to the base for pivotal movement about a first pivot axis, a handle articulated to the clamping arm or base for pivotal movement about a second pivot axis, a bridge element articulated to the handle or the clamping arm for pivotal movement about a third pivot axis, a first wedge element having a first wedge surface, and a second wedge element having a second wedge surface facing towards the first wedge surface. In a first positional range of the handle, the wedge surfaces are spaced apart. In a second positional range of the handle, the second wedge surface is supported on the first wedge surface, displacement of the first wedge element driving a displacement of the second wedge element. The bridge element is articulated to the first wedge element for pivotal movement about a fourth pivot axis.

Abstract: An embodiment of the invention relates to an apparatus for manufacturing particles, wherein the apparatus comprises a supply unit adapted for supplying a viscous raw material, a perforated body having a plurality of perforations and arranged to receive the viscous raw material from the supply unit to flow through the plurality of perforations, and a cutter arranged so that the viscous raw material flowing out of the plurality of perforations is cut into the particles by the cutter, wherein the apparatus is configured so that, during manufacturing the particles, a temperature of at least a portion of the perforated body is lower than a temperature of the viscous raw material flowing through the plurality of perforations, wherein the perforated body and the cutter are arranged relative to one another such that the cutter is cooled by thermal exchange with the perforated body during operation of the apparatus.

Abstract: A toggle clamp is provided which includes a base, a clamping arm articulated to the base for pivotal movement about a first pivot axis, a handle articulated to the clamping arm or base for pivotal movement about a second pivot axis, a bridge element articulated to the handle or the clamping arm for pivotal movement about a third pivot axis, a first wedge element having a first wedge surface, and a second wedge element having a second wedge surface facing towards the first wedge surface. In a first positional range of the handle, the wedge surfaces are spaced apart. In a second positional range of the handle, the second wedge surface is supported on the first wedge surface, displacement of the first wedge element driving a displacement of the second wedge element. The bridge element is articulated to the first wedge element for pivotal movement about a fourth pivot axis.

Abstract: The present invention relates to an operator platform for a construction machine and to a construction machine, particularly a road construction machine such as a road milling machine or a road paver, with an operator platform. The operator platform comprises an operator platform base, an operating panel and an operator seat, wherein an operating panel mount with a pivoting device is provided, by means of which the operating panel is pivotable about a vertical pivot axis between a first pivoting position and a second pivoting position. The operating panel mount comprises a height adjustment device which is configured such that the operating panel can be locked at different height positions independently of the pivoting positions.

Abstract: Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern.

Abstract: The present invention relates to a certain DPP-4 inhibitor for use in cardio- and/or renoprotective therapy, including in patients at high vascular risk.

Abstract: A fluid cartridge (100) for dispensing a fluid, the fluid cartridge (100) comprising a casing (102) for accommodating the fluid, a pressure feed interface (104) configured for being coupled to a pressure feed unit (106) for feeding the fluid in the casing (102) with pressurized medium, a fluid dispensing unit (108) configured for generating particles, particularly fluid particles, upon feeding the fluid in the casing (102) with pressurized medium, and a fluidic path (110) in the casing (102) being opened or openable for enabling the particles, particularly fluid particles, to leave the casing (102) through the fluidic path (110).

Abstract: The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.

Abstract: A Fabry-Pérot tuneable filter device is described with reflecting elements separated by an optical path length to form an optical resonator cavity. A first actuator means is directly or indirectly coupled with a first reflecting element. And the first actuator means is configured to modulate the optical path length between first and second reflecting elements by a modulation amplitude to thereby sweep the optical resonator cavity through a band of optical resonance frequencies with a sweep frequency of 70 kHz or more. And the mechanical coupling between selected elements of the arrangement is sufficiently low such that when operated at the sweep frequency, the selected elements act as a system of coupled oscillating elements. In addition or alternatively, the first actuator means is directly or indirectly coupled with the first reflecting element so as to substantially drive the first reflecting element only.

Abstract: A storage medium on which geographic data of a geographic region are stored together as map units, a corresponding method for generating a map from the geographic data, and a corresponding navigation device. In order to reduce the amount of data to be processed, the map units are structured hierarchically, map units of an nth order respectively corresponding to one geographic partial region, n being a natural number, and map units of an (n+1)th order respectively corresponding to one geographic subregion of one of the partial regions.

Abstract: A device (1) for discharging an electrical overvoltage includes an overvoltage discharge unit (10) having a non-linear current/voltage characteristic at least in sections. A first terminal electrode (16) of the overvoltage discharge unit (10) is connected to a high-voltage terminal (18) of the device (1). A second terminal electrode (22) of the overvoltage discharge unit (10) is connected to a low-voltage or ground terminal (24) of the device (1). The overvoltage discharge unit (10) is surrounded, at least in sections, by an insulating body (20). A cutting element (40) is connected to the low-voltage or ground terminal (24) and is disposed close to a high-voltage section of the overvoltage discharge unit (10). The cutting element cuts into the insulating body (20) when the insulating body (20) distends as a result of an electrical overload, enabling an are to be sparked and stabilized between the high-voltage section and the cutting element (40).

Abstract: The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The invention relates to the treatment of metabolic disorders in an overweight or obese patient characterized in that empagliflozin and one or more antiobesity drugs are administered to the patient.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.

Abstract: A method for detecting an imperfect mounting of an essentially rod-shaped metallic object in a metallic hollow shaft is provided. The imperfect mounting may lead to the formation of metallic particles. The rod-shaped object is mounted electrically insulated from the hollow shaft. The electrical resistance between the rod-shaped object and the hollow shaft is measured. An alert is issued when the electrical resistance is lower than a predefined level. A device includes a spin unit with a hollow drive shaft and a nozzle mounted inside the hollow shaft. The device is configured to use the inventive method.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.