Abstract: Compositions of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, a method for preparing curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, as well as the use of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound as a sealant, an adhesive material, a potting compound and/or a coating agent.

Abstract: Compositions of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, a method for preparing curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, as well as the use of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound as a sealant, an adhesive material, a potting compound and/or a coating agent.

Abstract: A compact in vitro diagnostic (WD) device is used to provide in vitro model-based diagnosis and a basis for model-based therapy planning. The IVD device and an associated procedure may be used to assess the effect of drugs on the electro-physiological phenotype of cardiomyocytes or any cell of a patient. The effects may be assessed in a clinical environment. The assessed information for the patient may be combined with clinical data for the patient and provided to a database. The database may collect the assessment results and clinical patient data for a plurality of patients. The information in the database may be used to assist in therapy planning for future patients.

Abstract: An apparatus for determining preferably Biologically Relevant Measurement Variables at membranes has at least one first plate-like or film-like substrate, which is made from at least one first material and has continuous openings or pores or can be perforated, and also has a second plate-like or film-like substrate which is made from at least one second material, to which measuring elements are assigned or on which measuring elements are situated. Cells or similar structures may be at least temporarily applied or permanently cultivated on the first substrate. According to the invention, the first substrate and the second substrate are assigned to one another at least during the measuring operation for determining the corresponding measurement variables, specifically preferably on flat sides which are opposite one another. In particular, this assignment is a connection of the two substrates, preferably a joining-together.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials. In particular, the present invention provides a composition for the production of a silicone rubber material, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a use of the catalyst according to the invention for the cross-linking of a silicone rubber material, as well as a use of the composition according to the invention for the production of a silicone rubber material, especially for the use as a sealant, an adhesive, or a coating agent.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials with a cross-linker on the basis of lactate. In particular, the present invention provides a composition for the production of a silicone rubber material with a cross-linker on the basis of lactate, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a method for the production of such a composition, as well as a use of the catalyst for the cross-linking of a silicone rubber material, in particular for cross-linking a silicone rubber material with a cross-linker on the basis of lactate, as well as a use of the composition of the present invention for the production of a silicone rubber material, in particular for use as a sealant, an adhesive, or a coating agent.

Abstract: An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.

Abstract: An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials. In particular, the present invention provides a composition for the production of a silicone rubber material, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a use of the catalyst according to the invention for the cross-linking of a silicone rubber material, as well as a use of the composition according to the invention for the production of a silicone rubber material, especially for the use as a sealant, an adhesive, or a coating agent.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials with a cross-linker on the basis of lactate. In particular, the present invention provides a composition for the production of a silicone rubber material with a cross-linker on the basis of lactate, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a method for the production of such a composition, as well as a use of the catalyst for the cross-linking of a silicone rubber material, in particular for cross-linking a silicone rubber material with a cross-linker on the basis of lactate, as well as a use of the composition of the present invention for the production of a silicone rubber material, in particular for use as a sealant, an adhesive, or a coating agent.

Abstract: An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.

Abstract: An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.

Abstract: A hardener for silicone rubber materials comprising a silane compound which comprises a 2-hydroxy-propionic acid alkyl ester radical.

Abstract: Display contrast in electro-optical display devices is improved using a drive circuit including pixel drive circuits and a common drive circuit. The pixel drive circuits are connected to pixel electrodes of the display device, and are operable to generate respective pixel drive signals that alternate between a first high voltage and a first low voltage differing in voltage by less than or equal to a process-limited maximum. The common drive circuit is connected to a common electrode of the display device, and is operable to generate a common drive signal alternating between a second high voltage and a second low voltage differing in voltage by more than the process-limited maximum. The common drive signal is asymmetrically bipolar with respect to the first low voltage of the pixel drive signal.

Abstract: A hardener for silicone rubber materials comprising a silane compound which comprises a 2-hydroxy-propionic acid alkyl ester radical.

Abstract: A method of providing suspended cells (10) for carrying out biological assays, comprising the steps of: a) providing a frozen cell suspension, b) bringing the frozen cell suspension into direct contact with an excess volume of thawing buffer (12), and c) incubating the solution of step b) at room temperature in order to thaw the cell suspension.

Abstract: An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip projects into the opening in such a way that it comes to bear against a cell membrane of the immobilized cell. The contact tip has a contact channel which ends at its top end. A hydrodynamic low pressure can be exerted upon the cell membrane via the contact channel, and the electrode is electrically connected to the contact channel. In a method for electrically contacting biological cells suspended in a liquid, a cell is immobilized above an opening provided in a substrate, and the immobilized cell is contacted via at least one electrode. For contacting the immobilized cell, a hydrodynamic low pressure is generated acting on a cell membrane through a contact tip projecting into the opening.

Abstract: An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip projects into the opening in such a way that it comes to bear against a cell membrane of the immobilized cell. The contact tip has a contact channel which ends at its top end. A hydrodynamic low pressure can be exerted upon the cell membrane via the contact channel, and the electrode is electrically connected to the contact channel. In a method for electrically contacting biological cells suspended in a liquid, a cell is immobilized above an opening provided in a substrate, and the immobilized cell is contacted via at least one electrode. For contacting the immobilized cell, a hydrodynamic low pressure is generated acting on a cell membrane through a contact tip projecting into the opening.

Abstract: A frequency detector for use with a PLL utilizes a counter and a preset value to produce frequency information related to a VCO signal. The frequency information is used to control the frequency of the VCO signal and to determine whether the VCO signal should be controlled by the frequency detector or a phase detector. Using the counter and preset value involves establishing a preset value that is used to obtain the desired frequency information. The preset value is set such that the counter is at one-half full-scale at the end of a known time period when the VCO signal is oscillating at a target frequency. When the preset value is set to such a value, the most significant bit of the counter after the known time period indicates whether the frequency of the VCO signal is above or below the target frequency.

Abstract: A technique for establishing a tuning signal window for a multi-band VCO involves setting the tuning signal window to an initial size, preferably a relatively small size, and determining whether the VCO is churning. When the VCO is determined to be churning, the tuning signal window is expanded until the VCO stops churning. In an embodiment, the tuning signal window is expanded incrementally until the tuning signal window is large enough to include a solution, where a solution is defined as an operating point along a frequency band that satisfies both the setpoint frequency and tuning window signal requirements. The tuning signal window can be set at an offset relative to the tuning signal zero to compensate for shifts in the frequency bands that may result from changes in operating conditions.