Abstract: A curable composition comprising a polyorganosiloxane, a silane-based crosslinker, a heterocyclic azasilane and an organophosphonic acid, and a process for preparing the curable composition and its use is provided.

Abstract: Compositions of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, a method for preparing curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, as well as the use of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound as a sealant, an adhesive material, a potting compound and/or a coating agent.

Abstract: Compositions of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, a method for preparing curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound, as well as the use of curable silicone rubber compounds containing at least one metal siloxane-silanol(-ate) compound as a sealant, an adhesive material, a potting compound and/or a coating agent.

Abstract: A compact in vitro diagnostic (WD) device is used to provide in vitro model-based diagnosis and a basis for model-based therapy planning. The IVD device and an associated procedure may be used to assess the effect of drugs on the electro-physiological phenotype of cardiomyocytes or any cell of a patient. The effects may be assessed in a clinical environment. The assessed information for the patient may be combined with clinical data for the patient and provided to a database. The database may collect the assessment results and clinical patient data for a plurality of patients. The information in the database may be used to assist in therapy planning for future patients.

Abstract: An apparatus for determining preferably Biologically Relevant Measurement Variables at membranes has at least one first plate-like or film-like substrate, which is made from at least one first material and has continuous openings or pores or can be perforated, and also has a second plate-like or film-like substrate which is made from at least one second material, to which measuring elements are assigned or on which measuring elements are situated. Cells or similar structures may be at least temporarily applied or permanently cultivated on the first substrate. According to the invention, the first substrate and the second substrate are assigned to one another at least during the measuring operation for determining the corresponding measurement variables, specifically preferably on flat sides which are opposite one another. In particular, this assignment is a connection of the two substrates, preferably a joining-together.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials. In particular, the present invention provides a composition for the production of a silicone rubber material, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a use of the catalyst according to the invention for the cross-linking of a silicone rubber material, as well as a use of the composition according to the invention for the production of a silicone rubber material, especially for the use as a sealant, an adhesive, or a coating agent.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials with a cross-linker on the basis of lactate. In particular, the present invention provides a composition for the production of a silicone rubber material with a cross-linker on the basis of lactate, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a method for the production of such a composition, as well as a use of the catalyst for the cross-linking of a silicone rubber material, in particular for cross-linking a silicone rubber material with a cross-linker on the basis of lactate, as well as a use of the composition of the present invention for the production of a silicone rubber material, in particular for use as a sealant, an adhesive, or a coating agent.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials. In particular, the present invention provides a composition for the production of a silicone rubber material, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a use of the catalyst according to the invention for the cross-linking of a silicone rubber material, as well as a use of the composition according to the invention for the production of a silicone rubber material, especially for the use as a sealant, an adhesive, or a coating agent.

Abstract: The present invention relates to a catalyst for the cross-linking of silicone rubber materials with a cross-linker on the basis of lactate. In particular, the present invention provides a composition for the production of a silicone rubber material with a cross-linker on the basis of lactate, wherein the composition comprises a catalyst, which comprises at least two compounds, which are different from each other and which are selected independently of each other from metal salts of carboxylic acids. In addition, the present invention provides a method for the production of such a composition, as well as a use of the catalyst for the cross-linking of a silicone rubber material, in particular for cross-linking a silicone rubber material with a cross-linker on the basis of lactate, as well as a use of the composition of the present invention for the production of a silicone rubber material, in particular for use as a sealant, an adhesive, or a coating agent.

Abstract: A hardener for silicone rubber materials comprising a silane compound which comprises a 2-hydroxy-propionic acid alkyl ester radical.

Abstract: A hardener for silicone rubber materials comprising a silane compound which comprises a 2-hydroxy-propionic acid alkyl ester radical.

Abstract: A method of providing suspended cells (10) for carrying out biological assays, comprising the steps of: a) providing a frozen cell suspension, b) bringing the frozen cell suspension into direct contact with an excess volume of thawing buffer (12), and c) incubating the solution of step b) at room temperature in order to thaw the cell suspension.

Abstract: An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip projects into the opening in such a way that it comes to bear against a cell membrane of the immobilized cell. The contact tip has a contact channel which ends at its top end. A hydrodynamic low pressure can be exerted upon the cell membrane via the contact channel, and the electrode is electrically connected to the contact channel. In a method for electrically contacting biological cells suspended in a liquid, a cell is immobilized above an opening provided in a substrate, and the immobilized cell is contacted via at least one electrode. For contacting the immobilized cell, a hydrodynamic low pressure is generated acting on a cell membrane through a contact tip projecting into the opening.

Abstract: An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip projects into the opening in such a way that it comes to bear against a cell membrane of the immobilized cell. The contact tip has a contact channel which ends at its top end. A hydrodynamic low pressure can be exerted upon the cell membrane via the contact channel, and the electrode is electrically connected to the contact channel. In a method for electrically contacting biological cells suspended in a liquid, a cell is immobilized above an opening provided in a substrate, and the immobilized cell is contacted via at least one electrode. For contacting the immobilized cell, a hydrodynamic low pressure is generated acting on a cell membrane through a contact tip projecting into the opening.

Abstract: A technique for establishing a tuning signal window for a multi-band VCO involves setting the tuning signal window to an initial size, preferably a relatively small size, and determining whether the VCO is churning. When the VCO is determined to be churning, the tuning signal window is expanded until the VCO stops churning. In an embodiment, the tuning signal window is expanded incrementally until the tuning signal window is large enough to include a solution, where a solution is defined as an operating point along a frequency band that satisfies both the setpoint frequency and tuning window signal requirements. The tuning signal window can be set at an offset relative to the tuning signal zero to compensate for shifts in the frequency bands that may result from changes in operating conditions.

Abstract: The frequency changes in a bang-bang PLL that are generated using a digital phase detector's up/down signal are initially set to produce a faster pull-in rate and then reduced to produce a slower pull-in rate. The faster pull-in involves relatively large frequency changes and the slower pull-in rate involves smaller frequency changes. The changes in frequency of a bang-bang PLL can be implemented using a step size controller that includes timing control logic and step size logic. The function of the timing control logic is to control the timing of step size changes. The function of the step size logic is to set the step size of the frequency changes that are made by the VCO in response to the pd_up/down signal that is delivered directly to the VCO from the digital phase detector.

Abstract: A technique for reducing the likelihood that a frequency detector will incorrectly assert control over a VCO because of metastable-induced errors involves qualifying frequency detector control signals by requiring multiple consecutive control signals that indicate the frequency detector should assert control over the VCO before the frequency detector is allowed to assert control over the VCO. In an embodiment, the frequency detector control signals are qualified by a series of full-swing library cell flip-flops.

Abstract: The present invention relates to a method and a device for contacting a microfluidic structure. The device comprises a receptacle for the microfluidic structure and also a contact unit. According to one aspect of the invention, the contact unit has at least one hollow needle, which is designed for piercing a layer of elastic material which is provided on the microfluidic structure.

Abstract: The frequency changes in a bang-bang PLL that are generated using a digital phase detector's up/down signal are initially set to produce a faster pull-in rate and then reduced to produce a slower pull-in rate. The faster pull-in involves relatively large frequency changes and the slower pull-in rate involves smaller frequency changes. The changes in frequency of a bang-bang PLL can be implemented using a step size controller that includes timing control logic and step size logic. The function of the timing control logic is to control the timing of step size changes. The function of the step size logic is to set the step size of the frequency changes that are made by the VCO in response to the pd_up/down signal that is delivered directly to the VCO from the digital phase detector.

Abstract: Centering a multi-band VCO involves comparing a VCO tuning signal to a pre-established tuning signal window to determine whether to change the frequency band of the multi-band VCO. The frequency band of the multi-band VCO can be changed only when the tuning signal is outside the tuning signal window. Further, the frequency band can be changed as long as the VCO is being controlled by a frequency detector. Once the multi-band VCO achieves lock, the multi-band VCO is changed by at least one more frequency band as long as the VCO tuning signal is still outside the tuning signal window.