Abstract: The present invention relates to a method for identifying splice switching oligonucleotides (SSOs) able to modulate expression of a target protein in a cell by promoting incorporation of a pseudoexon into the mature mRNA upon binding to the pre-mRNA in the region +9 to +39 downstream to the 5? splice site of said pseudoexon. The invention also relates to SSOs obtained by said method and uses thereof. In particular, the present invention relates to allele specific splice switching oligonucleotides (SSOs).

Abstract: The present disclosure sets forth a one-way clutch. The one-way clutch can function with one or no races as opposed to conventional prior art one-way clutches. In so doing, the overall size and weight requirements of the one-way clutch are drastically reduced, which in turn drastically reduces the overall size and weight requirements of the transmission and vehicle employing the transmission as well. The present disclosure also provides a one-way clutch having an outer race provided by axially spaced plates. An inner race is rotatably mounted with respect to one of the plates and the inner race has a ratchet surface. Ratchet pawls are pivotably mounted with respect to the plates and have unidirectional engagement with the ratchet surface of the inner race. In addition to reducing material and labor production costs, such lessened size and weight penalties translate into higher transmission efficiency and better vehicle fuel economy.

Abstract: Various aspects of a method and system for processing a monetary transaction are disclosed herein. The method includes registration, at a server, of a first virtual currency instrument that corresponds to a first account and one or more other virtual currency instruments that corresponds to one or more other accounts. The registered first virtual currency instrument is associated with a first value. The method further includes reception, at the server, of a redemption request of the registered first virtual currency instrument to process the monetary transaction. The received redemption request is higher than the first value associated with the registered first virtual currency instrument by an excess value.

Abstract: Wear bands for heavy duty struts are disclosed. The wear bands include multiple layers such as a base metal layer sandwiched between an outer layer and an intermediate layer along with a solid lubricant layer disposed opposite the intermediate layer from the base metal layer. The outer layer engages an interior surface of the strut housing, which slidably accommodates a rod. The solid lubricant layer, which is the innermost layer, engages an outer surface of the rod so that the wear band is sandwiched between the rod and the housing and provides a solid lubricant layer for engaging the sliding rod.

Abstract: Methods and systems for electronically displaying financial data involve, for example, providing access to an authorized user via a client computing device to financial data on a back-end server using a processor coupled to memory; likewise using the processor, sending the financial data to the client computing device from the back-end server; and also using the processor, rendering a three-dimensional graphic display showing a plurality of geographic locations associated with the financial data on the client computing device.

Abstract: Wear bands for heavy duty struts are disclosed. The wear bands include multiple layers such as a base metal layer sandwiched between an outer layer and an intermediate layer along with a solid lubricant layer disposed opposite the intermediate layer from the base metal layer. The outer layer engages an interior surface of the strut housing, which slidably accommodates a rod. The solid lubricant layer, which is the innermost layer, engages an outer surface of the rod so that the wear band is sandwiched between the rod and the housing and provides a solid lubricant layer for engaging the sliding rod.

Abstract: A programmable electronic card assembly is provided. The programmable electronic card assembly comprising a smart phone having a receptacle, and a programmable electronic card positionable within and removable from the receptacle of the smart phone for providing power and communications interfaces with the electronic card, the card including a card body and a reprogrammable magnetic stripe positioned on a surface of the card body.

Abstract: A testing apparatus for a strut having a cylinder portion and a rod portion is provided. The testing apparatus includes a frame assembly, a loading mechanism, and a rotating assembly. The frame assembly includes a retainer portion configured to hold the cylinder portion of the strut about a first axis. The loading mechanism includes two actuators angularly disposed between the frame assembly and the rod portion of the strut. The actuators can cooperatively load the strut along the first axis. The rotating assembly is coupled between the frame assembly and the rod portion of the strut. The rotating assembly can rotate the rod portion relative to the cylinder portion.

Abstract: A programmable electronic card is provided. The electronic card comprising a card body having a graphical user interface screen positioned on a front surface of the card body, a reprogrammable magnetic stripe positioned on a rear surface of the card body, a processor positioned within the card body and in electrical communication with the reprogrammable magnetic stripe and the graphical user interface screen and a memory positioned within the card body in communication with the processor, said memory storing information relating to a plurality of card accounts owned by a user, wherein the graphical user interface screen allows a user to select one of the plurality of card accounts for use and displays a graphical emulation of a physical card on the user interface screen corresponding to the selected card account, which electronically reprograms the magnetic stripe to include information relating to the selected credit card for subsequent use of the card at a point of sale.

Abstract: Methods and systems for performing mobile collections utilize computer hardware and software for receiving delivery information including, for example, an agent identifier, a delivery identifier and details of a scheduled delivery, and a buyer identifier. Upon receiving the delivery identifier and a submit request from a communication device of the agent, an authorization request is sent to a communication device of the buyer. On receiving the buyer identifier and an authorization response from the communication device of buyer, a settlement request for the delivery is sent to a banking network. Thereafter, payment for the delivery is received in an account of the supplier.

Abstract: The present disclosure sets forth a one-way clutch. The one-way clutch can function with one or no races as opposed to conventional prior art one-way clutches. In so doing, the overall size and weight requirements of the one-way clutch are drastically reduced, which in turn drastically reduces the overall size and weight requirements of the transmission and vehicle employing the transmission as well. The present disclosure also provides a one-way clutch having an outer race provided by axially spaced plates. An inner race is rotatably mounted with respect to one of the plates and the inner race has a ratchet surface. Ratchet pawls are pivotably mounted with respect to the plates and have unidirectional engagement with the ratchet surface of the inner race. In addition to reducing material and labor production costs, such lessened size and weight penalties translate into higher transmission efficiency and better vehicle fuel economy.

Abstract: The torque converter includes a torque input member and an impeller assembly operatively coupled with the torque input member. A turbine assembly is connected with the impeller and a lock-up clutch is interposed between the turbine assembly and the torque input member. The lock-up clutch provides torque translation between the torque input member and the turbine assembly and includes an annular piston mounted to the turbine assembly and a friction plate movably supported relative to the annular piston and operatively disposed between the annular piston and torque input member. A first friction member is operatively disposed between the friction plate and the torque input member, and a second friction member is operatively disposed between the friction plate and the annular piston. Torque is translated from the torque input member through the first friction member, the friction plate, the second friction member, and the annular piston to the turbine assembly.

Abstract: Processes for the production of a stabilised vaccine composition of labile immunogens, wherein a fluid comprising one or more immunogens is sprayed into a reactor containing fluidised particles of a pharmaceutically acceptable water soluble material at a temperature of about 25° C. to about 50° C., such that the immunogen coats and is dried onto the particles under the fluidising conditions, and thereafter collecting from said reactor dried immunogen containing particles having a moisture content between about 0.1% w/w to about 10% w/w are described. Also described are stabilised vaccine compositions of labile immunogens.

Abstract: The torque converter includes a torque input member and an impeller assembly operatively coupled with the torque input member. A turbine assembly is connected with the impeller and a lock-up clutch is interposed between the turbine assembly and the torque input member. The lock-up clutch provides torque translation between the torque input member and the turbine assembly and includes an annular piston mounted to the turbine assembly and a friction plate movably supported relative to the annular piston and operatively disposed between the annular piston and torque input member. A first friction member is operatively disposed between the friction plate and the torque input member, and a second friction member is operatively disposed between the friction plate and the annular piston. Torque is translated from the torque input member through the first friction member, the friction plate, the second friction member, and the annular piston to the turbine assembly.

Abstract: Methods for preparing products containing moisture-sensitive materials, including biological materials such as proteins, peptides or live cells, comprising at least the steps: (i) providing a coating liquid comprising at least one active, a sugar polymer and a water soluble/miscible solvent; (ii) providing a quantity of microparticles comprising at least water soluble gel forming solid particles; (iii) fluidizing said quantity of microparticles within a processing chamber of a of a suitable apparatus to form a fluidized bed of said microparticles; (iv) spraying said coating liquid onto said fluidized bed from beneath the fluidized bed to coat said microparticles therewith under saturated moisture conditions; and (vi) allowing coated microparticles to dry, are described. Also described are compositions and uses.

Abstract: A connector assembly is provided for use with a handheld computing system. The connector assembly includes a first connector including a plurality of contact elements. A second connector resides on a cradle and includes a plurality of contact elements that mate with the contact elements on the handheld computer. A coupling structure is configured to extend from the cradle and to couple to the handheld computer. The coupling structure causes a portion of the handheld computer to bias into the cradle so as to direct the first connector to remain in contact with the second connector.

Abstract: A growth promotant comprising microgranules having a core consisting of one or more enzymes selected from: i) protein digesting enzymes; ii) carbohydrate digesting enzymes; iii) fat digesting enzymes; and iv) fiber digesting enzymes in an immobilized form; the core being encapsulated within a water soluble film, and coated with an enteric coating comprising an alkali soluble, acid insoluble polymer, or a high molecular weight polymer whose structure is substituted with or contains windows of fatty acid or other material capable of being solubilized by intestinal juices. A method for increasing animal growth comprising the administration of a growth promoting amount of the growth promotant is also described, as is a method of producing the growth promotant.