Abstract: A mechanical ventilation device comprises at least one electronic controller configured to: receive ultrasound data related to a thickness of a diaphragm of a patient during inspiration and expiration while the patient undergoes mechanical ventilation therapy with a mechanical ventilator; calculate a diaphragm thickness metric based on at least the ultrasound data; and when the calculated diaphragm thickness metric does not satisfy an acceptance criterion, at least one of: output an alert indicative of the calculated diaphragm thickness metric failing to satisfy the acceptance criterion; and output a recommended adjustment to one or more parameters of the mechanical ventilation therapy delivered to the patient.

Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Abstract: An intubation assistance device includes an electronic controller configured to: generate a patient respiratory tract geometry model of at least a portion of a human respiratory tract by inputting one or more patient variables into a statistical shape model (SSM) of at least a portion of the human respiratory tract; select a recommended endotracheal tube (ETT) size by modeling at least one ETT model inserted into the patient respiratory tract geometry model to form a virtual fit model and estimating at least one fit parameter based on the virtual fit model; and display the recommended ETT size on a display device.

Abstract: An X-ray imaging system (XI) configured for phase contrast and/or dark-field imaging The system comprises an X-ray source (XS) operable to cause X-radiation to emanate from a focal spot (SF) of the source (XS) and an X-ray sensitive detector (D) operable to SMF detect the X-radiation after interaction of said X-radiation with an object to be imaged, if present, between the X-ray source and the detector (D). A control logic (CL) is operable to cause the X-ray imaging apparatus to operate in any one of two modes, an object image acquisition mode and a scattering measurement mode. When in scattering measurement mode, the X-radiation receivable at the detector comprises a higher proportion of scattering radiation than in X-radiation receivable when the system is in object image acquisition mode.

Abstract: A system (IPS) and related method for image processing, in particular dark-field or phase contrast imaging to reduce motion artifacts. The system comprises an input interface (IN) for receiving a series of projection images (?) acquired by an X-ray imaging apparatus (XI) of an object (OB) for a given projection direction, the imaging apparatus (XI) configured for phase-contrast and/or dark-field imaging A phase-contrast and/or dark-field image generator (IGEN) applies an image generation algorithm to compute a first image based on the series the projection images (?). A motion artifact detector (MD) detects a motion artifact in the first image. A combiner (?) combines, if a motion artifact is so detected, a part of the first image with a part of at least one auxiliary image to obtain a combined image. The auxiliary image was previously computed by a gated application of the image generation algorithm in respect of a subset of the series of the projection images (?).

Abstract: An intubation assistance device includes an electronic controller configured to: identify, from one or more images of a patient, information about the patient including at least a diameter of a trachea and a length of an intubation pathway; determine a recommended ETT size including an ETT diameter and an ETT depth of insertion from the determined diameter of the trachea and the determined length of the intubation pathway; and display the recommended ETT size on a display device.

Abstract: Data in X-ray images of a medical device is processed in order to reduce vibration artifacts in differential phase contrast imaging. A proportionality factor between an object induced phase shift for a first x-ray energy bin and an object induced phase shift for a second x-ray energy bin is provided. At least one of a dark field signal and an object induced phase shift is determined from a detected intensity value of a pixel for the first energy bin and a detected intensity value of the pixel for the second energy bin using the proportionality factor.

Abstract: The invention relates to a method for producing a component from a medium manganese flat steel product having 4 to less than 10 wt. % Mn, 0.0005 to 0.9 wt. % C, 0.02 to 10 wt. % Al, the remainder iron, including unavoidable steel-accompanying elements, and having a TRIP effect at room temperature. In order to produce a component, which is distinguished by very high strengths and an increased residual strain and re-shaping capacity, the flat steel product, according to the invention, is re-shaped by at least one re-shaping step to form a component and, before and/or during and/or after the at least one re-shaping step, the flat steel product is cooled down to a temperature of the flat steel product of less than room temperature to ?196° C. The invention further relates to a component produced by this method and to a use for said components.

Abstract: Disclosed are systems and methods for secure and seamless set up and modification of bolus calculator parameters for a bolus calculator tool by a health care provider (HCP). In one aspect, a method for enabling HCP set up of a bolus calculator includes providing a server accessible by both an HCP and a patient; upon login by the HCP, displaying, or transmitting for display, a fillable form, the fillable form including one or more fields for entry of one or more bolus calculator parameters; receiving data from the fillable form, the data corresponding to one or more bolus calculator parameters; and upon login by the patient, transmitting data to a device associated with the patient, the transmitted data based on the received data, where the transmitted data corresponds to one or more of the bolus calculator parameters in a format suitable for entry to a bolus calculator.

Abstract: The invention relates to a system and a method for active grating position tracking in X-ray differential phase contrast imaging and dark-field imaging. The alignment of at least one grating positioned in an X-ray imaging device is measured by illuminating a reflection area located on the grating with a light beam, and detecting a reflection pattern of the light beam reflected by the reflection area. The reflection pattern is compared with a reference pattern corresponding to an alignment optimized for X-ray differential phase contrast imaging, and the X-ray imaging device is controlled upon the comparison of the reflection pattern and the reference pattern.

Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Abstract: A multiflow pump for fluids, having an electromagnetic translator drive, a displacement piston unit, a pump head, and at least one outlet valve device. The displacement piston contains a bearing journal with a spring receptacle, a carrier plate, and a plurality of pump pistons, wherein the displacement piston unit is configured in one piece.

Abstract: The present invention relates to a system (10) for X-ray dark-field, phase contrast and attenuation image acquisition. The system comprises an X-ray source (20), an interferometer arrangement (30), an X-ray detector (40), a control unit (50), and an output unit (60). An axis is defined extending from a centre of the X-ray source to a centre of the X-ray detector. An examination region is located between the X-ray source and the X-ray detector. The axis extends through the examination region, and the examination region is configured to enable location of an object to be examined. The interferometer arrangement is located between the X-ray source and the X-ray detector. The interferometer arrangement comprises a first grating (32) and a second grating (34). For a first mode of operation: The control unit is configured to control at least one lateral movement transducer (70) to move the first grating or move the second grating in a lateral position direction perpendicular to the axis.

Abstract: A roller for transporting a flexible substrate is described. The roller includes a main body having a plurality of gas supply slits provided in an outer surface of the main body. The plurality of gas supply slits extends in a direction of a central rotation axis of the roller. Further, the roller includes a sleeve provided circumferentially around and in contact with the main body. The sleeve has a plurality of gas outlets extending in a radial direction (R) and being provided above the plurality of gas supply slits.

Abstract: The present invention covers azaquinoline compounds of general formula (I), with A being (A1) or (A2), and in which T, R1, R2, R3, R4, R5, R6 and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to a detector (10) for a dark-field and/or phase-contrast interferometric imaging system. The detector comprises a plurality of pixels (50), a plurality of first detector arrays (20), pixel a plurality of second detector arrays (30), and a processing unit (40). The plurality of pixels are arranged in a two-dimensional pattern. Each pixel comprises a first detector array and a second detector array. Each first detector array comprises a plurality of fingers (22). Each second detector array comprises a plurality of fingers (32). For each pixel the fingers of the first detector array are interleaved alternately with the fingers of the second detector array. For each pixel interaction with an incident X-ray photon can lead to charge generation in at least one finger of the first detector array of that pixel and can lead to charge generation in at least one finger of the second detector array of that pixel.

Abstract: In order to improve the mechanical stability of an X-ray grating with top bridges for X-ray dark field imaging and/or X-ray phase contrast imaging, it is proposed to reduce or prevent the undesired high stress on the top bridges by a change in the manufacturing process. Specifically, it is proposed to electroplate the top bridges after the bending. In other words, the electroplating of the top bridges is performed on the bent geometry.

Abstract: Dental adhesive set which contains an adhesive and an applicator which is coated with a vanadium(IV) salt.

Abstract: Disclosed are systems and methods for secure and seamless set up and modification of bolus calculator parameters for a bolus calculator tool by a health care provider (HCP). In one aspect, a method for enabling HCP set up of a bolus calculator includes providing a server accessible by both an HCP and a patient; upon login by the HCP, displaying, or transmitting for display, a fillable form, the fillable form including one or more fields for entry of one or more bolus calculator parameters; receiving data from the fillable form, the data corresponding to one or more bolus calculator parameters; and upon login by the patient, transmitting data to a device associated with the patient, the transmitted data based on the received data, where the transmitted data corresponds to one or more of the bolus calculator parameters in a format suitable for entry to a bolus calculator.

Abstract: Bone Trabeculae Index for X-Ray Dark-Field Radiography A method (200) and system (20) for expressing signals in a dark field X-ray image of bone (34; 44) in units of a trabecular quantity are disclosed, in which an X-ray dark field image of a bone having a trabecular network is acquired (204) at an image resolution that is not capable of resolving the trabecular network (41) of the bone. Information about the positioning of the scan bone relative to the X-ray dark field imaging apparatus used for acquisition is determined. Signals in the X-ray dark field image of the bone are converted (206) into a corresponding trabecular quantity, wherein the conversion accounts for the determined information about the positioning of the bone and depends on a plurality of generated X-ray dark field image signal normalization values, generated for a sample bone.