Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.

Abstract: In order to improve the mechanical stability of an X-ray grating with top bridges for X-ray dark field imaging and/or X-ray phase contrast imaging, it is proposed to reduce or prevent the undesired high stress on the top bridges by a change in the manufacturing process. Specifically, it is proposed to electroplate the top bridges after the bending. In other words, the electroplating of the top bridges is performed on the bent geometry.

Abstract: An imaging system (702) includes a reconstructor (716) configured to reconstruct obtained cone beam projection data with a voxel-dependent redundancy weighting such that low frequency components of the cone beam projection data are reconstructed with more redundant data than high frequency components of the cone beam projection data to produce volumetric image data. A method includes reconstructing obtained cone beam projection data with a voxel-dependent redundancy weighting such that low frequency components are reconstructed with more redundant data than high frequency components to produce volumetric image data.

Abstract: The present invention relates to a device (10) and related method and computer-program product for planning an acquisition by a CT scanner (20). The device receives a pre-scan image of the object from the scanner via an input (12). A processor (16), in use of the device, obtains a parameter selection based on the pre-scan image, in which this parameter selection comprises at least axial upper and lower scan range limits of a region of the object to be scanned. The processor determines a value indicative of an image gradient or gradient component in the pre-scan image at the upper and/or lower scan range limit or in a predetermined neighborhood thereof. If this value exceeds a threshold, a user is informed via an output (18) that the selected scan range does not satisfy a quality criterium for reconstruction and/or a new parameter selection is determined by repositioning, resizing and/or changing an orientation of the selected region to be scanned.

Abstract: A signal processing system (SPS) and related method for tomographic reconstruction of phase contrast or dark-field imagery. An improved weighting model is used to eliminate sensitivity gradient variations to so reduce artifacts is the reconstructed imagery. The system (SPS) is not reliant on iterative reconstruction algorithms. Instead, quicker reconstruction algorithms such as filtered back-projection can be used herein.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: Apart from signal changes in three-dimensional X-ray dark-field (3D-DAX) imaging, also significant signal heterogeneity can be revealed. A method and apparatus for heterogencity analysis in 3D X-ray dark field imaging are provided, to enable the generation of parameters for an objective quantification and assessment of signal heterogeneity in 3D-DAX image data of a subject. In addition, a system for 3D X-ray imaging comprising said apparatus, a computer program element for carrying out the method and/or controlling the apparatus and/or system, and a computer readable medium having stored thereon the program element, are provided.

Abstract: There is provided a computer-implemented method of estimating lung volume from radiographic images. The method comprises: registering (102) a two dimensional radiographic image (12) of a patients chest to a three dimensional radiographic image (14) of the patients chest to estimate data describing projection geometry (16) of an imaging setup used to capture the two dimensional radiographic image; using the projection geometry to estimate (104) at least one radiographic magnification factor (18) relating to the imaging setup; and calculating (106) an estimated lung volume (20) using the two dimensional radiographic image and the at least one radiographic magnification factor.

Abstract: A reconstruction system includes a decomposer (204) configured to decompose at least two sets of projection data generated via kVp switching between at least two radiation source voltages. Each set corresponds to a different one of the at least two radiation source voltages. The system further includes a spectral channel (206) configured to process the at least two sets of projection data and generate spectral image data. The system further includes a non-spectral channel (208) configured to process the at least two sets of projection data and generate non-spectral image data for a predetermined reference kVp.

Abstract: Concepts for generating a dark X-ray (DAX) model adapted to represent relations between a DAX signal, a respiratory state, and a respiratory disease grade, as well as concepts for using the DAX model are proposed. In particular, as relations between these variables are modelled, the difference between a DAX signal of a subject at a respiratory state, compared to a DAX signal of a subject at a reference respiratory state may be assessed. Thus, the diagnostic accuracy of DAX imaging may be improved.

Abstract: A composition for reducing/eliminating aerosolization during dental/surgical irrigation procedures comprising at least one liquid or solid carrier and at least one polymer, wherein the at least one polymer comprises at least hydroxyalkyl cellulose polymer, at least one poly(ethylene oxide) polymer or a mixture thereof and wherein the at least one polymer is not soluble in the liquid carrier.

Abstract: The present invention relates to a system (10) for X-ray dark-field, phase contrast and attenuation image acquisition. The system comprises an X-ray source (20), an interferometer arrangement (30), an X-ray detector (40), a control unit (50), and an output unit (60). An axis is defined extending from a centre of the X-ray source to a centre of the X-ray detector. An examination region is located between the X-ray source and the X-ray detector. The axis extends through the examination region, and the examination region is configured to enable location of an object to be examined. The interferometer arrangement is located between the X-ray source and the X-ray detector. The interferometer arrangement comprises a first grating (32) and a second grating (34). For a first mode of operation: The control unit is configured to control at least one lateral movement transducer (70) to move the first grating or move the second grating in a lateral position direction perpendicular to the axis.

Abstract: A detector for a dark-field and/or phase-contrast interferometric imaging system comprises pixels, first detector arrays, second detector arrays, and a processor. For each pixel, each of the first and second detector arrays is configured to detect a cumulative charge associated with fingers of the respective detector array. For each pixel, the processor is configured to assign an X-ray interaction event to either the first detector array or the second detector array based on the detector array that has the highest cumulative charge.

Abstract: A respiration monitoring device includes at least one electronic processor programmed to perform a respiration monitoring method including receiving ultrasound imaging data of a diaphragm of a patient as a function of time during inspiration and expiration while the patient undergoes mechanical ventilation therapy with a mechanical ventilator; receiving respiratory data of the patient as a function of time during the inspiration and expiration while the patient undergoes the mechanical ventilation therapy; calculating an intrinsic positive end-expiratory pressure (iPEEP) value for the patient based on the ultrasound imaging data and the respiratory data; and displaying, on a display device, a representation of the calculated iPEEP value.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.

Abstract: A mechanical ventilation assessment assistance device includes at least one electronic processor; and a non-transitory storage medium storing instructions readable and executable by the at least one electronic processor to perform a mechanical ventilation assessment assistance method including obtaining an image of a patient (P) receiving mechanical ventilation; generating or updating a patient-specific lung model of at least one lung of the patient based on the obtained image; simulating a response of the patient to a mechanical ventilation therapy using the generated or updated patient-specific lung model; comparing the simulated response with an actual response of the patient to the mechanical ventilation therapy; based on the comparison, determining an imaging recommendation for acquiring an image of at least one lung of the patient; and outputting the determined imaging recommendation.

Abstract: The present invention relates to a system (1010) for X-ray dark field, phase contrast and attenuation image acquisition, the system comprising: an X-ray source (1020); an interferometer arrangement (1030); an X-ray detector (1040); a control unit (1050); at least one vibration transducer (1080); a processing unit (1090); and an output unit (1060). An axis is defined extending from a centre of the X-ray source to a centre of the X-ray detector. An examination region is located between the X-ray source and the X-ray detector, wherein the axis extends through the examination region, and wherein the examination region is configured to enable location of an object to be examined. The interferometer arrangement is located between the X-ray source and the X-ray detector, and wherein the interferometer arrangement comprises a first grating (1032) and a second grating (1034).

Abstract: The present invention refers to providing a system that allows to very accurately determine the state of a disease, like COPD, in a patient. The system (100) comprises a unit (101) for providing images of the region of interest corresponding to different states of the region of interest, a unit (102) for elastically registering the images to each other resulting in an elastic registration output, a unit (103) for determining a specific tissue region in an image, a unit (104) for determining a specific elastic registration output for the specific tissue region based on the determined elastic registration output, and a unit (105) for determining an elastic indicator for the specific tissue type based on the specific elastic registration output. Thus, a state of a disease that influences the elastic properties of the specific tissue type can be determined very accurately.

Abstract: The invention relates to a system for reconstructing an image of an object. The system (100) comprises means (110) providing projection data acquired by an imaging unit, like a CT system, with an FOV, means (120) generating estimated image data indicative of a part of an object (20) located outside the FOV (210), means (130) estimating virtual projection data based on virtual settings of a virtual imaging unit comprising a virtual FOV, means (140) generating fused projection data by fusing the provided projection data with the virtual projection data, and means (150) reconstructing a final image. This allows basing the reconstruction on a complete set of projection information for the object and thus providing an image with a high image quality.