Patents by Inventor Thomas Koehler

Thomas Koehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210321970
    Abstract: The invention is related to processing x-ray imaging data, specifically phase contrast x-ray imaging data, and addresses the problems associated, for example, with vibrations in grating-based differential phase contrast imaging by making use of spectral information. It was realized that one may make use of the spectral information in determining the vibration state of the Moiré pattern based on multi-energy-bin x-ray detectors, the energy independence of vibration-induced Moiré pattern phase shifts, the energy dependence of object-induced Moiré pattern phase shifts and a phantom designed to allow for measuring the dependence of the object-induced phase shift as a function of the energy bin. In particular, it was found that by suitable data processing the vibration-induced shifts and the like can be disentangled from the object properties and hence vibration artifacts in the image are reduced, while there is no particular need for changing the basic physical structure of the imaging device.
    Type: Application
    Filed: March 23, 2018
    Publication date: October 21, 2021
    Inventors: MATTIAS BARTELS, THOMAS KOEHLER, EWALD ROESSL
  • Patent number: 11149145
    Abstract: This invention relates to novel macromers containing dithiocarbonate (or xanthate) groups, novel preformed stabilizers comprising macromers, and novel polymer polyols comprising the novel macromers and/or novel preformed stabilizers. This invention also relates to processes for the preparation of these materials. Other aspects of this invention include foams comprising the novel polymer polyols and a process for preparing foam comprising the novel polymer polyols.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: October 19, 2021
    Assignees: Covestro LLC, Covestro Deutschland AG
    Inventors: Rick L. Adkins, Jack R. Reese, Thomas Ernst Müller, Christoph Gürtler, Urs Rauwald, Muhammad Afzal Subhani, Verena Jakoby, Burkhard Köhler, Walter Leitner
  • Publication number: 20210316070
    Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.
    Type: Application
    Filed: March 16, 2021
    Publication date: October 14, 2021
    Inventors: Gary A. Morris, Scott M. Belliveau, Esteban Cabrera, JR., Rian Draeger, Laura J. Dunn, Timothy Joseph Goldsmith, Hari Hampapuram, Christopher Robert Hannemann, Apurv Ullas Kamath, Katherine Yerre Koehler, Patrick Wile McBride, Michael Robert Mensinger, Francis William Pascual, Philip Mansiel Pellouchoud, Nicholas Polytaridis, Philip Thomas Pupa, Anna Leigh Davis, Kevin Shoemaker, Brian Christopher Smith, Benjamin Elrod West, Atiim Joseph Wiley
  • Publication number: 20210317114
    Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 14, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Arturo VEGAS, Sean QUINNELL, Daniel SHEEHY, Kelly TAN, Luke CEO, Stephen Thomas NESTOR, Angela Nicole KOEHLER, Becky LEIFER, Shelby DOYLE
  • Patent number: 11141116
    Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: October 12, 2021
    Assignee: DexCom, Inc.
    Inventors: Esteban Cabrera, Jr., Lauren Danielle Armenta, Scott M. Belliveau, Jennifer Blackwell, Leif N. Bowman, Rian Draeger, Arturo Garcia, Timothy Joseph Goldsmith, John Michael Gray, Andrea Jean Jackson, Apurv Ullas Kamath, Katherine Yerre Koehler, Paul Kramer, Aditya Sagar Mandapaka, Michael Robert Mensinger, Sumitaka Mikami, Gary A. Morris, Hemant Mahendra Nirmal, Paul Noble-Campbell, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Brian Christopher Smith, Atiim Joseph Wiley
  • Publication number: 20210298704
    Abstract: The present invention relates to an apparatus (10) for generating X-ray imaging data. It is described to position (210) a first grating between an X-ray source and a second grating. The second grating is positioned (220) between the first grating and a third grating. A third grating is positioned (230) between the second grating and an X-ray detector. An object is positioned (240) between the first grating and the third grating. At least one of the three gratings has a pitch attribute of having a constant grating pitch. At least one of the three gratings has a pitch attribute of having a varying grating pitch. Both gratings of an adjacent pair of gratings are bent such that a distance between the two adjacent gratings is constant as a function of fan angle. Both gratings of the adjacent pair of gratings that are bent have the same pitch attribute. An X-ray detector detects (250) at least some of the X-rays transmitted by the three gratings and the object.
    Type: Application
    Filed: August 1, 2019
    Publication date: September 30, 2021
    Inventors: THOMAS KOEHLER, GEREON VOGTMEIER, ANDRIY YAROSHENKO
  • Patent number: 11130768
    Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: September 28, 2021
    Assignee: Bayer Animal Health GmbH
    Inventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Adeline Köhler, Thomas Ilg, Claudia Welz, Hans-Georg Schwarz, Ulrich Görgens, Walter Hübsch, Johannes Köbberling
  • Patent number: 11129691
    Abstract: An active marker device (100) is introducible into a human tissue and for tracking a region of interest of a human body. The active marker device includes a light source (101) for emitting light such that the emitted light can be detected by an optical sensor. In this way, the active marker device and/or the region of interest can be tracked by a tracking system including the optical sensor. The active marker device (100) also includes a switch (102) for turning the light source on and off and for operating the light source in a pulsed mode.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: September 28, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Bernardus Hendrikus Wilhelmus Hendriks, Michael Grass, Thomas Koehler, Harold Agnes Wilhelmus Schmeitz, Roland Proksa, Vishnu Vardhan Pully, Marco Andreas Jacobus Van As, Waltherus Cornelis Jozef Bierhoff, Franciscus Marinus Antonius Maria Van Gaal, Drazenko Babic
  • Publication number: 20210292478
    Abstract: Provided herein is a process for preparing a heterocycle-functional polyoxyalkylene polyol, in which a polyoxyalkylene polyol having unsaturated groups is reacted with a heterocyclic compound. Also provided herein is a heterocycle-functional polyoxyalkylene polyol, a method of crosslinking a heterocycle-functional polyoxyalkylene polyol, a crosslinked, heterocycle-functional polyoxyalkylene polyol, and related processes.
    Type: Application
    Filed: July 16, 2019
    Publication date: September 23, 2021
    Inventors: Daniela Cozzula, Burkhard Köhler, Muhammad Afzal Subhani, Piotr Putaj, Walter Leitner, Thomas Ernst Mueller, Christoph Guertler, Volker Marker
  • Patent number: 11123034
    Abstract: An imaging system includes radiation source that emits radiation that traverses an examination region and a portion of a subject therein and a detector array that detects radiation that traverses the examination region and the portion of the subject therein and generates a signal indicative thereof. A volume scan parameter recommender recommends at least one spectral scan parameter value for a volume scan of the portion of the subject based on a spectral decomposition of first and second 2D projections acquired by the radiation source and detector array. The first and second 2D projections have different spectral characteristics. A console employs the recommended at least one spectral scan parameter value to perform the volume scan of the portion of the subject.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: September 21, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dirk Schaefer, Axel Thran, Thomas Koehler
  • Patent number: 11116470
    Abstract: The invention relates to beam hardening correction in X-ray Dark-Field imaging of a subject including a first material and a second material, the first and second material having different beam hardening properties. As the X-ray imaging data includes information on the internal structure of the imaged subject, such information may be used, together with appropriate calibration data to identify the beam hardening contributions occurring in the imaged area of the subject, so to allow for a correction of artifacts due to beam hardening in X-ray Dark-Field imaging.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: September 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Andriy Yaroshenko, Hanns-Ingo Maack, Thomas Koehler, Fabio De Marco, Lukas Benedict Gromann, Willer Konstantin, Peter Noel
  • Patent number: 11116465
    Abstract: A method of a virtual X-ray colonoscopy includes scanning (204) a dark-field contrast (144) insufflated colon lumen (140) with an X-ray scanner (110) configured for dark-field-contrast, which generates dark-field-contrasted projection data and attenuation projection data. The dark-field-contrasted projection data and the attenuation projection data are reconstructed (206) into one or more dark-field-contrasted images (148).
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: September 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Roland Proksa, Alexander André Fingerle, Daniela Muenzel, Franz Josef Pfeiffer, Thomas Koehler, Peter Benjamin Theodor Noel, Maximilian Von Teuffenbach, Julia Herzen, Konstantin Willer
  • Publication number: 20210272338
    Abstract: A reconstruction system includes a decomposer (204) configured to decompose at least two sets of projection data generated via kVp switching between at least two radiation source voltages. Each set corresponds to a different one of the at least two radiation source voltages. The system further includes a spectral channel (206) configured to process the at least two sets of projection data and generate spectral image data. The system further includes a non-spectral channel (208) configured to process the at least two sets of projection data and generate non-spectral image data for a predetermined reference kVp.
    Type: Application
    Filed: June 24, 2019
    Publication date: September 2, 2021
    Inventors: THOMAS KOEHLER, KEVIN MARTIN BROWN, ROLAND PROKSA
  • Patent number: 11107599
    Abstract: The present invention relates to a grating for X-ray phase contrast and/or dark-field imaging. It is described to form a photo-resist layer on a surface of a substrate. The photo-resist layer is illuminated with radiation using a mask representing a desired grating structure. The photo-resist layer is etched to remove parts of the photo-resist layer, to leave a plurality of trenches that are laterally spaced from one across the surface of the substrate. A plurality of material layers are formed on the surface of the substrate. Each layer is formed in a trench. A material layer comprises a plurality of materials, wherein the plurality of materials are formed one on top of the other in a direction perpendicular to the surface of the substrate. The plurality of materials comprises at least one material that has a k-edge absorption energy that is higher than the k-edge absorption energy of Gold and the plurality of materials comprises Gold.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: August 31, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Thomas Koehler
  • Patent number: 11098153
    Abstract: The present invention relates to a method for producing a prepolymer that contains carbon-carbon multiple bonds, a polyol component A) being reacted with component B) that contains isocyanate groups and the polyol component comprising a polyether carbonate polyol that contains carbon-carbon multiple bonds.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: August 24, 2021
    Assignee: Covestro Deutschland AG
    Inventors: Muhammad Afzal Subhani, Burkhard Koehler, Walter Leitner, Thomas Ernst Müller, Christoph Gürtler
  • Patent number: 11096639
    Abstract: The invention relates to a subject support device (1) to be used in a projection data acquisition apparatus (2) for acquiring projection data of a subject (3). The subject support device comprises a support component (4) providing a support surface (5) for supporting the subject while acquiring the projection data, a diffraction grating (6) for diffracting x-rays, and a moving unit (7, 8) for moving the support component and the diffraction grating relative to each other. This relative movement can allow for a movement of the support component such that the subject is moved through x-rays (16) for determining projection data of different parts of the subject, while the diffraction grating can still be traversed by the x-rays. These projection data can be used for generating a relatively large phase-contrast and/or dark-field projection image.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 24, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ewald Roessl, Thomas Koehler
  • Patent number: 11098154
    Abstract: A process for preparing a phosphorus-functional polyethercarbonate polyol, comprising reacting a polyethercarbonate polyol having unsaturated groups with a phosphorus-functional compound of formula (Ia): wherein X=O or S; and wherein R1 and R2 are selected from the group consisting of C1-C22 alkyl, C1-C22 alkoxy, C1-C22 alkylsulfanyl, C6-C70 aryl, C6-C70 aryloxy, C6-C70 arylsulfanyl, C7-C70 aralkyl, C7-C70 aralkyloxy, C7-C70 aralkylsulfanyl, C7-C70 alkylaryl, C7-C70 alkylaryloxy, C7-C70 alkylarylsulfanyl, or wherein R1 and R2 are bridged to one another directly and/or via heteroatoms and are selected from the group consisting of C1-C22 alkylene, oxygen, sulfur, and NR5, wherein R5 is hydrogen, C1-C22 alkyl, C1-C22 acyl, C7-C22 aralkyl, or C6-C70 aryl radical. A process for preparing a phosphorus-functional polyurethane polymer is disclosed.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: August 24, 2021
    Assignee: COVESTRO DEUTSCHLAND AG
    Inventors: Thomas Ernst Mueller, Christoph Guertler, Kai Laemmerhold, Muhammad Afzal Subhani, Burkhard Koehler, Walter Leitner
  • Publication number: 20210241883
    Abstract: A system (100) for reconstruction of medical images over a network comprises a scheduler (302) that schedules a reconstruction request (108) and the reconstruction request includes a medical image reconstruction of a subject according to an imaging protocol The scheduling includes scheduling of a plurality of events, each event with a corresponding time, and the plurality of events include at least one event with the corresponding time selected from a group consisting of a first time (520) to transmit raw image data (114) over a first network from a source node (116) to a reconstruction node (106), a second time (522) to reconstruct the medical image (118) by the reconstruction node, and a third time (524) to transmit the reconstructed medical image over a second network from the reconstruction node to a destination node (120).
    Type: Application
    Filed: June 17, 2019
    Publication date: August 5, 2021
    Inventors: THOMAS NETSCH, MICHAEL GÜNTER HELLE, THOMAS KOEHLER, CLAAS BONTUS, CHRISTOPHE MICHAEL JEAN SCHÜLKE, TANJA NORDHOFF, DOUGLAS B. MCKNIGHT
  • Publication number: 20210217140
    Abstract: In a method and system for reconstructing computed tomography image data in which CT image data is de-noised. Then simulated noise is added, followed by another de-noising step to estimate the bias. Then, the estimated bias information is used to correct the original de-noised image data to arrive at second pass image data.
    Type: Application
    Filed: March 24, 2017
    Publication date: July 15, 2021
    Inventors: Thomas KOEHLER, Bernhard Johannes BRENDEL, Rolf Dieter BIPPUS, Frank BERGNER
  • Publication number: 20210186451
    Abstract: The invention relates to a data processor (1) for processing 3D radiographic imaging data. The processor comprises an input (2) for receiving the imaging data and for providing a motion signal indicative of a motion of the imaged subject. The processor comprises an image segmenter (4) for segmenting a body part of interest in a first image included in or derived from the imaging data, and a gating function calculator (5) for calculating temporal gating functions for voxels that belong to the body part taking the motion signal into account. The processor comprises an image reconstructor (3) for reconstructing the imaging data into reconstructed three-dimensional images, by taking the temporal gating functions into account such as to associate each of the reconstructed three-dimensional images with a corresponding phase of the motion.
    Type: Application
    Filed: May 28, 2019
    Publication date: June 24, 2021
    Inventors: MICHAEL GRASS, THOMAS KOEHLER