Patents by Inventor Thomas Krahn

Thomas Krahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
    Publication number: 20050227972
    Abstract: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
    Type: Application
    Filed: November 28, 2002
    Publication date: October 13, 2005
    Applicant: Bayer Healthcare AG
    Inventors: Ulrich Rosentreter, Thomas Kramer, Mitsuyuki Shimada, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Kerstin Henninger, Johannes-Peter Stasch, Ralf Wischnat
  • Substituted alkyl uracils and thereof
    Publication number: 20050159431
    Abstract: The invention relates to novel compounds of formula (I), to a method for the production thereof, and to their use as medicament active ingredients for the prophylaxis and/or treatment of diseases.
    Type: Application
    Filed: January 3, 2003
    Publication date: July 21, 2005
    Applicant: Bayer Healthcare AG
    Inventors: Barbara Albrecht, Michael Gerisch, Michael Harter, Thomas Krahn, Felix Oehme, Karl-Heinz Schlemmer, Henning Steinhagen
  • Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (pars)
    Publication number: 20050075347
    Abstract: The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.
    Type: Application
    Filed: November 2, 2001
    Publication date: April 7, 2005
    Inventors: Barbara Albrecht, Michael Gerisch, Gabriele Handke-Erguden, Axel Jensen, Thomas Krahn, Werner Nickl, Felix Oehme, Karl-Heinz Schlemmer, Henning Steinhagen
  • Substituted piperazine cyclohexane carboxilic acid amides and the use thereof
    Publication number: 20050054637
    Abstract: The present invention relates to substituted piperazinecyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in pharmaceuticals, in particular for the prophylaxis and/or treatment of cardiovascular disorders.
    Type: Application
    Filed: October 1, 2002
    Publication date: March 10, 2005
    Inventors: Erwin Bischoff, Thomas Krahn, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Substituted 2 5-diamidoindoles as ece inhibitors for the treatment of cardiovascular diseases
    Publication number: 20050038101
    Abstract: The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals.
    Type: Application
    Filed: September 16, 2002
    Publication date: February 17, 2005
    Inventors: Jens-Kerim Erguden, Thomas Krahn, Christian Schroder, Johannes-Peter Stasch, Stefan Weigand, Hanno Wild, Michael Brands
  • Substituted cyclohexane derivatives and the use thereof in medicaments for treating cardiovascular diseases
    Publication number: 20040235830
    Abstract: The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the urogenital tract and cerebrovascular diseases.
    Type: Application
    Filed: April 22, 2004
    Publication date: November 25, 2004
    Inventors: Susanne Rohrig, Andreas Stolle, Julio C. Castro-Palomino, Helmut Haning, Gabriele Handke-Erguden, Noemi Daviu-Folguera, Holger Paulsen, Josef Pernerstorfer, Stephan-Nicholas Wirtz, Henning Steinhagen, Wolfgang Thielemann, Erwin Bischoff, Ulrich Ebbinghaus-Kintscher, Peter Ellinghaus, Joachim Hutter, Thomas Krahn, Frank Wunder, Klemens Lustig, Joachim Schuhmacher, Frank Sussmeier
  • Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands
    Publication number: 20040176417
    Abstract: Compounds of the formula (I) 1
    Type: Application
    Filed: January 15, 2004
    Publication date: September 9, 2004
    Inventors: Ulrich Rosentreter, Thomas Kramer, Mistuyuki Shimaa, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Kerstin Henninger, Johannes-Peter Stasch
  • Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use as adenosine receptor-selective ligands
    Publication number: 20040162427
    Abstract: The invention relates to the use of compounds of formula (I) as medicaments, to the novel compounds of formula (I) themselves, and to a method for the production thereof.
    Type: Application
    Filed: April 12, 2004
    Publication date: August 19, 2004
    Inventors: Ulrich Rosentreter, Thomas Krmer, Andrea Vaupel, Walter Hbsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Stasch
  • Substituted phenylcyclohexanecarboxamides and their use
    Publication number: 20040122004
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the Formula (I) 1
    Type: Application
    Filed: November 17, 2003
    Publication date: June 24, 2004
    Applicant: Bayer Aktiengesellschaft
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Muller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor
    Publication number: 20040110946
    Abstract: The invention relates to compounds of formula (I), a method for the production thereof and the use of the same as pharmaceuticals.
    Type: Application
    Filed: January 7, 2004
    Publication date: June 10, 2004
    Inventors: Ulich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch, Mitsuyuki Shimada
  • Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use cardiovascular preparations
    Publication number: 20040102626
    Abstract: The invention relates to the compounds of formula (I), to a method for producing them and to their use as medicaments.
    Type: Application
    Filed: January 7, 2004
    Publication date: May 27, 2004
    Inventors: Ulrich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Peter Stasch, Mitsuyuki Shimada
  • Substituted amidoalkyl-uracils and their use
    Patent number: 6649618
    Abstract: Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: November 18, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Härter, Barbara Albrecht, Michael Gerisch, Gabriele Handke, Joachim Hütter, Axel Jensen, Thomas Krahn, Joachim Mittendorf, Felix Oehme, Karl-Heinz Schlemmer, Henning Steinhagen
  • Substituted phenylcyclohexanecarboxamides and their use
    Patent number: 6649616
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: November 18, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Müller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays
    Publication number: 20030092081
    Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.
    Type: Application
    Filed: October 3, 2002
    Publication date: May 15, 2003
    Inventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
  • Method and device for taking measurements of cells which are contained in a liquid environment
    Publication number: 20030080314
    Abstract: A method and a device are used for carrying out measurements on cells located in a liquid environment. Each cell is positioned with an underside of its membrane on a surface having a channel running through it. A negative pressure is established to aspirate the cells. Each cell is electrically scanned via at least one electrode which is spaced apart from the cell. The negative pressure is preferably established in a pulse-like manner to rupture the membrane in such a way that the cell interior enclosed by the membrane is connected to the channel.
    Type: Application
    Filed: November 20, 2002
    Publication date: May 1, 2003
    Inventors: Wilfried Nisch, Martin Stelzle, Alfred Stett, Thomas Krahn, Thomas Muller, Christoph Methfessel
  • Substituted amidoalkyl-uracils and their use
    Publication number: 20030022905
    Abstract: Novel amidoalkyl-uracil derivatives of the formula (I) 1
    Type: Application
    Filed: July 16, 2001
    Publication date: January 30, 2003
    Inventors: Michael Harter, Barbara Albrecht, Michael Gerisch, Gabriele Handke, Joachim Hutter, Axel Jensen, Thomas Krahn, Joachim Mittendorf, Felix Oehme, Karl-Heinz Schlemmer, Henning Steinhagen
  • Substituted phenylcyclohexanecarboxamides and their use
    Publication number: 20030008881
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) 1
    Type: Application
    Filed: August 30, 2001
    Publication date: January 9, 2003
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Muller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • MASKING BACKGROUND FLUORESCENCE AND LUMINESCENCE IN OPTICAL ANALYSIS OF BIOMEDICAL ASSAYS
    Publication number: 20020022274
    Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.
    Type: Application
    Filed: November 20, 1998
    Publication date: February 21, 2002
    Inventors: THOMAS KRAHN, WOLFGANG PAFFHAUSEN, ANDREAS SCHADE, MARTIN BECHEM, DELF SCHMIDT
  • Masking background fluorescence and luminescence in optical analysis of biomedical assays
    Publication number: 20020015969
    Abstract: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably improved if to the fluorescent dye 4 already present in addition a masking dye 9, which absorbs the excitation light 6 for the fluorescent dye 4 and/or its emission light 7, is added to the solution 3 and/or if a separating layer 10 permeable to the solution and absorbing and/or reflecting the excitation light 6 or the emission light 7 is applied to the cell layer at the bottom 2. This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer 10 must in this case be composed such that it has a high power of reflection for the luminescent light 11.
    Type: Application
    Filed: September 28, 2001
    Publication date: February 7, 2002
    Inventors: Thomas Krahn, Wolfgang Paffhausen, Andreas Schade, Martin Bechem, Delf Schmidt
  • Use of efomycins
    Patent number: 6291515
    Abstract: The present invention relates to the use of known efomycins and elaiophylins for the treatment of autoimmune disorders, to new natural substances efomycins M and T, and processes for their preparation; in particular to their use as medicaments in psoriasis therapy.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: September 18, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst-Peter Antonicek, Erwin Bischoff, Daniel Gondol, Oliver Gutbrod, Thomas Krahn, Maria-Luisa Rodriguez, Helmuth Schütz