Patents by Inventor Thomas Kramps

Thomas Kramps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
    Publication number: 20040038901
    Abstract: An isolated polypeptide comprising a peptide which consists of a legless homology domain (HD); wherein the peptide inhibits Lgs function in colon cancer cells; and a composition comprising the same, are disclosed.
    Type: Application
    Filed: September 22, 2003
    Publication date: February 26, 2004
    Applicant: UNIVERSITAT ZURICH
    Inventors: Konrad Basler, Erich Brunner, Barbara Froesch, Thomas Kramps, Oliver Peter
  • Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
    Publication number: 20030114413
    Abstract: The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 19, 2003
    Applicant: UNIVERSITAT ZURICH
    Inventors: Konrad Basler, Erich Brunner, Barbara Froesch, Thomas Kramps, Oliver Peter
  • Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
    Publication number: 20020086986
    Abstract: The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.
    Type: Application
    Filed: July 27, 2001
    Publication date: July 4, 2002
    Inventors: Konrad Basler, Erich Brunner, Barbara Froesch, Thomas Kramps, Oliver Peter