Abstract: Systems and methods for managing speed thresholds for a fleet of vehicles are disclosed. Input is used to provide associations between particular weather-relation conditions (such as rain) and arithmetic operations, that may be used to determine a current speed threshold as a function of a local posted speed limit at the current location of a vehicle. The current speed threshold is subsequently used to detect whether vehicles are exceeding the current speed threshold.

Abstract: A magnetic coupling assembly includes a rotatable male coupling member, a rotatable female coupling member, a static separation member, a first channel, a second channel, a third channel, and a magnetic coupling section of the static separation member, wherein the magnetic coupling section is a section of the static separation member. The rotatable female coupling member and the rotatable male coupling member are rotatably coupled by magnets through the magnetic coupling section. The first channel, the second channel, and the third channel contain fluid forced to flow through the first, second, and third channels for cooling and rotodynamic stabilization.

Abstract: The present invention provides glucose sensitive insulin derivatives comprising a macrocycle, a glucose mimetic and human insulin or an analogue thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such glucose sensitive insulin derivatives, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes.

Abstract: A lace tensioning device includes a housing component having an interior region, a first aperture, and a second aperture, and a spool component that is rotatably positionable within the interior region of the housing component. The spool component has a central cylindrical member and a lumen that extends through the central cylindrical portion. The spool component is rotatable within the interior region of the housing component to align one end of the lumen with the first aperture and to align an opposite end of the lumen with the second aperture to enable a lace to be inserted through the first aperture, the lumen, and the second aperture so that opposing ends of the lace are positioned exterior to the housing component. A knot may then be tied in the lace and the lace retracted to couple the lace with the housing component and spool component.

Abstract: Systems and methods are provided for improving thermal management strategies of a cathode assembly of an X-ray tube. In one embodiment, an X-ray tube comprises an anode assembly and a cathode assembly, wherein the cathode assembly includes one or more elements that include an internal porous section for controlling a flow of heat within the cathode assembly during operation of the X-ray tube. In this way, heat conduction to temperature sensitive aspects of the cathode assembly may be reduced, while enabling sufficient heat transfer to other parts of the cathode assembly to minimize deformation.

Abstract: The invention relates to a method for repairing a damaged point of a fiber composite component which is formed from at least one fiber ply of a fiber material of a fiber composite substance and a matrix material of the fiber composite substance, in which matrix material the fiber material is embedded, wherein the method comprises the following steps: removing the damaged point from the fiber composite component and producing a repair cavity in the fiber composite component, introducing at least one reparative fiber ply of a fiber material into the repair cavity produced in the fiber composite component, and curing the matrix material, in which the fiber material of the reparative fiber ply is embedded, after introducing the reparative fiber ply into the repair cavity of the fiber composite component, wherein at least one reparative fiber ply having a ply thickness that is smaller than the ply thickness of the fiber plies of the rest of the fiber composite component is introduced into the repair cavity.

Abstract: A reel based closure device includes a housing, a tension member, a spool that is rotatably positioned within the housing, and a tightening component that is positioned axially above the spool and that is operably coupled therewith so that an operation of the tightening component causes the spool to rotate within the housing to wind the tension member about the spool. The reel based closure device also includes a coupling component that is separate from the tension member and that frictionally engages with a distal end of the tension member so that the coupling component is removably fixed to the tension member. The spool component includes a coupling feature within which the coupling component is positioned to attach the tension member to the spool.

Abstract: Disclosed herein are systems and methods for automated insulin delivery that reduce a risk of hypoglycemia from automatically delivering correction boluses. Rather than automatically delivering a correction bolus when a current or future predicted glucose level of a user is over a high glucose threshold, the system can review additional factors to determine whether an automatic correction bolus is appropriate. For example, the system can be prevented from delivering an automatic correction bolus if the user's glucose levels are falling at greater than a predetermined rate and/or if a current glucose level is greater than a future predicted glucose level even if the user's current or predicted future glucose levels is over the high threshold.

Abstract: Systems and methods are provided for improving thermal management strategies of a cathode assembly of an x-ray tube. In one embodiment, an x-ray tube comprises an anode assembly and a cathode assembly, wherein the cathode assembly includes one or more elements that include an internal porous section for controlling a flow of heat within the cathode assembly during operation of the x-ray tube. In this way, heat conduction to temperature sensitive aspects of the cathode assembly may be reduced, while enabling sufficient heat transfer to other parts of the cathode assembly to minimize deformation.

Abstract: The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention also relates to novel intermediates. Finally, the invention provides a pharmaceutical composition comprising the insulin derivatives of the invention and the use of such a composition in the treatment or prevention of medical conditions relating to diabetes.

Abstract: A method for determining a distance between components has the steps of providing a first conductive section in or on the first component in a region directed toward the second component, providing a second conductive section in or on the second component in a region directed toward the first conductive section, feeding a first voltage pulse into a first connection of the first conductive section, capturing a reflection voltage pulse in response to the first voltage pulse at the first connection, determining an impedance profile along the first conductive section by evaluating the reflection voltage pulse, and determining a distance between the components along the first conductive section by calculating a corresponding local distance, associated with the determined impedance profile, between the first conductive section and the second conductive section.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: The present invention provides glucose sensitive insulin derivatives comprising a macrocycle, a glucose mimetic and human insulin or an analogue thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such glucose sensitive insulin derivatives, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes.

Abstract: An indication device for monitoring the structural integrity of a repair location on a laminate structure, produced from a composite material, of a part of an aircraft outer skin is specified. The indication device has at least one elongate, thin indicator strip. The indicator strip is detachably applied to the outer layer of the laminate structure in the immediate vicinity of the repair location. The indicator strip is designed to indicate a predefined residual strength of an adhesive joint of a repair patch to the surrounding composite material.

Abstract: A system for assessing potential cybersecurity threats to a subject system is provided. The system includes a computer system including at least one processor in communication with at least one memory device. The at least one processor is programmed to: receive a subject system to analyze, determine a potential hazard event associated with the subject system, generate an attack graph associated with the potential hazard event, wherein the attack graph includes a plurality of actions, determine an exploitability score for each of the plurality of actions, determine an uncertainty level for each of the plurality of actions based on the corresponding exploitability score, aggregate the plurality of actions including the corresponding exploitability scores and the corresponding uncertainty levels to determine one or more vulnerabilities of the subject system, and generate a response to the one or more vulnerabilities of the subject system.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein “X” is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I?), which is: R1?-X?—R2?, in which either the moeities R1? or R2? or X? carry a drug that is covalently attached to the diboron compound.

Abstract: The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K27, and the second K residue is designated KT; which derivative comprises two albumin binding moieties attached to K27 and KT, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC—(CH2)x—CO— and HOOC—C6H4—O—(CH2)y—CO—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —NH—(CH2)2—(O—(CH2)2)k—O—(CH2)n—CO—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or este

Abstract: Systems and methods for managing speed thresholds for a fleet of vehicles are disclosed. Input is used to provide associations between particular weather-relation conditions (such as rain) and arithmetic operations, that may be used to determine a current speed threshold as a function of a local posted speed limit at the current location of a vehicle. The current speed threshold is subsequently used to detect whether vehicles are exceeding the current speed threshold.

Abstract: Systems and methods for detecting a sitting duck scenario of a vehicle on or near a road are disclosed. The current location and speed of the vehicle are used for different comparisons and/or determinations, including a comparison to road-specific information to determine whether the vehicle is in a particular proximity of a highway, and a determination whether the vehicle has been stationary continuously for at least a specified duration. Additional comparisons and/or determinations may be used. If such an occurrence has been detected, one or more notifications are generated, and provided to one or more of the vehicle operator and/or a remote computing server.

Abstract: The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K27, and the second K residue is designated KT; which derivative comprises two albumin binding moieties attached to K27 and KT, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC—(CH2)2—CO— and HOOC—C6H4—O—(CH2)y—CO—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —NH—(CH2)2—(O—(CH2)2)k—O—(CH2)n—CO—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or este