Patents by Inventor Thomas Kruse Hansen

Thomas Kruse Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds with growth hormone releasing properties
    Patent number: 6555570
    Abstract: Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: April 29, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Bernd Peschke, Jesper Lau, Behrend Friedrich Lundt, Michael Ankersen, Brett Watson, Kjeld Madsen
  • Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
    Publication number: 20030064979
    Abstract: This invention relates to oxalylamide inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B) and/or T-cell Protein Tyrosine Phosphatase (TC-PTP) and/or Protein Tyrosine Phosphatases (PTPases) having an aspartic acid (Asp) in position 48 (PTP1B numbering, Chernoff et al, Proc Natl Acad Sci USA 87: 2735-2789 (1989)) and a method of inhibiting such PTPases by exposing the enzyme to inhibitor compounds of formula 1 1
    Type: Application
    Filed: June 27, 2002
    Publication date: April 3, 2003
    Inventors: Thomas Kruse Hansen, Ole Hvilsted Olsen, Anders Klarskov Petersen, Jesper Lau, Henrik Sune Andersen, Niels Peter Hundahl Moller
  • Compounds with growth hormone releasing properties
    Publication number: 20030055261
    Abstract: Compounds of peptide mimetic nature having the general formula I formula I 1
    Type: Application
    Filed: February 5, 2002
    Publication date: March 20, 2003
    Inventors: Thomas Kruse Hansen, Bernd Peschke, Jesper Lau, Behrend Friedrich Lundt, Michael Ankersen, Brett Watson, Kjeld Madsen
  • Compounds with growth hormone releasing properties
    Publication number: 20030040483
    Abstract: Compounds of peptide mimetic nature having the general formula I 1
    Type: Application
    Filed: March 23, 2000
    Publication date: February 27, 2003
    Inventors: Thomas Kruse Hansen, Bernd Peschke, Jesper Lau, Behrend Friedrich Lundt, Michael Ankersen, Brett Watson, Kjeld Madsen
  • Modulators of Protein Tyrosine Phosphatases (PTPases)
    Publication number: 20020151561
    Abstract: The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, 1
    Type: Application
    Filed: July 9, 2001
    Publication date: October 17, 2002
    Inventors: Henrik Sune Andersen, Thomas Kruse Hansen, Jesper Lau, Niels Peter Hundahl Moller, Ole Hvilsted Olsen, Frank Urban Axe, Farid Bakir, Yu Ge, Daniel Dale Holsworth, Luke Milburn Judge, Michael James Newman, Roy Teruyuki Uyeda, Barry Zvi Shapira
  • Modulators of protein tyrosine phosphatases (PTPases)
    Publication number: 20020099073
    Abstract: The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP (TC-PTP), 1
    Type: Application
    Filed: July 9, 2001
    Publication date: July 25, 2002
    Inventors: Henrik Sune Andersen, Thomas Kruse Hansen, Jesper Lau, Niels Peter Hundahl Moller, Ole Hvilsted Olsen, Frank Urban Axe, Farid Bakir, Yu Ge, Daniel Dale Holsworth, Luke Milburn Judge, Michael James Newman, Roy Teruyuki Uyeda, Barry Zvi Shapira
  • Modulators of protein tyrosine phosphateses (PTPases)
    Patent number: 6410556
    Abstract: Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: June 25, 2002
    Assignees: Novo Nordisk A/S, Ontogen Corporation
    Inventors: Henrik Sune Andersen, Thomas Kruse Hansen, Jesper Lau, Niels Peter Hundahl Møller, Ole Hvilsted Olsen, Frank Urban Axe, Yu Ge, Daniel Dale Holsworth, Todd Kevin Jones, Luke Milburn Judge, Wiliam Charles Ripka, Barry Zvi Shapira, Roy Teruyuki Uyeda
  • Compounds with growth hormone releasing properties
    Patent number: 6350767
    Abstract: The present invention relates to compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: February 26, 2002
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Bernd Peschke, Thomas Kruse Hansen, Nils Langeland Johansen, Michael Ankersen
  • Compounds with growth hormone releasing properties
    Patent number: 6303620
    Abstract: Disclosed are 4,4-disubstituted and 3,3-disubstituted piperidine compounds of formula I wherein D, E, G, J, R1, a, b, c, and d are defined in the specification, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: October 16, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Michael Ankersen
  • Compounds with growth hormone releasing properties
    Patent number: 6274584
    Abstract: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (1): wherein a, b, A, R1, L1, D, R3, R4, R2, L2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: August 14, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Bernd Peschke, Michael Ankersen, Thomas Kruse Hansen, Henning Thøgersen
  • Compounds with growth hormone releasing properties
    Patent number: 6127341
    Abstract: Compounds of the general formula I ##STR1## compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are described.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: October 3, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Jesper Lau, Bernd Peschke, Michael Ankersen, Kjeld Madsen, Nils Langeland Johansen
  • Compounds with growth hormone releasing properties
    Patent number: 6127354
    Abstract: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: October 3, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Bernd Peschke, Michael Ankersen, Thomas Kruse Hansen, Henning Th.o slashed.gersen
  • Compounds with growth hormone releasing properties
    Patent number: 6127391
    Abstract: Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: October 3, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Bernd Peschke, Jesper Lau, Behrend Friedrich Lundt, Michael Ankersen, Brett Watson, Kjeld Madsen
  • Compounds with growth hormone releasing properties
    Patent number: 6013658
    Abstract: There are disclosed novel synthetic peptides of formula (I) ##STR1## where A, B, D, E, F, G, J, m, n, and p are defined in the specification. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient, methods of stimulating the release of growth hormone, and the use of such compounds of formula (I) are also disclosed.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 11, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Jesper Lau, Bernd Peschke, Thomas Kruse Hansen, Nils Langeland Johansen, Michael Ankersen
  • Compounds with growth hormone releasing properties
    Patent number: 5977178
    Abstract: Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: November 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Bernd Peschke, Jesper Lau, Behrend Friedrich Lundt, Michael Ankersen, Brett Watson, Kjeld Madsen
  • Compounds with growth hormone releasing properties
    Patent number: 5922770
    Abstract: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: July 13, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Bernd Peschke, Michael Ankersen, Thomas Kruse Hansen, Henning Th.o slashed.gersen
  • Compounds with growth hormone releasing properties
    Patent number: 5919777
    Abstract: The present invention relates to novel compounds of the general formula I ##STR1## which can be used for treating medical disorders resulting from a deficiency in growth hormone.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: July 6, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Kruse Hansen, Bernd Pesche, Knud Erik Andersen
  • N-substituted naphthofused lactams
    Patent number: 5817654
    Abstract: The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: October 6, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Henning Thogersen, Birgit Sehested Hansen, Bernd Peschke, Thomas Kruse Hansen, Knud Erik Andersen