Abstract: A method for switching railcars at a railroad yard includes accessing a list of selected railcars for an outgoing train. The method further includes generating a plurality of train consists that each comply with a set of train rules. The method further includes displaying indications of the generated train consists and their associated number of railyard switch moves on an electronic display. The method further includes receiving a user selection of a desired train consist from the plurality of displayed train consists. The method further includes generating a plurality of switch lists according to the desired train consist and a current inventory of railcars in the railyard. The switch lists include instructions about how to form the desired train consist in the railyard. The method further includes displaying the plurality of switch lists on the electronic display.

Abstract: The present disclosure provides technologies for performing in vitro transcription that can generate product RNA preparations with reduced levels of certain contaminants (e.g., aberrant products), and particularly of double-stranded RNA (dsRNA).

Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).

Abstract: The invention relates to a dental tool having a shank region, which is formed for coupling to a dental handpiece, and also having a work region, which is connected to the shank region. In this case, the shank region of the dental tool is formed so that there is the possibility of latchable insertion and removal without actuation. In particular, at least the shank region can consist of plastics material. As a result, inter alia facilitated handling of the tool and inexpensive production of the tool are rendered possible.

Abstract: A compensating element having a first and a second assembly, wherein a locking mechanism is provided which can be switched over between a first and a second operating state. In the first operating state, the first assembly is connected fixedly to the second assembly and, in the second operating state, the first and second assemblies are connected to each other via a spring mechanism in such a manner that they are movable relative to each other. The locking mechanism includes an electric motor that can be used to switch over between the first and the second operating state. A locking ring is or is not braced against at least three balls depending on its rotational position with respect to a center axis. The locking ring is connected in terms of rotary drive to the electric motor via a torsion spring which is elastic with respect to the center axis.

Abstract: A method (100) is proposed for operating an internal combustion engine (210), which comprises a lean-burn engine having compression-ignition, having a throttle valve (213) in an air path (212) upstream of the internal combustion engine (210) and an exhaust gas posttreatment system (202) downstream of the internal combustion engine (210), comprising a control of the internal combustion engine (210) according to a present load demand (130) using metering of an amount of fuel in dependence on the present load demand; and if a load demand (130) is absent in a heating operating mode, further comprising partially closing (140) the throttle valve (213) and defining a minimum value for the amount of fuel, which is greater than zero. Furthermore, a computing unit and a computer program for carrying out such a method (100) are proposed.

Abstract: A method for steering a steerable interceptor missile driven by an engine for intercepting a moving target during a midcourse phase of an interception, includes steering the missile with real steering commands produced at respective steering times based on free control parameters formed as a current parameter vector. The free control parameters are constantly and repeatedly optimized during the midcourse phase by an optimization method for optimizing the control parameters. The optimization method is carried out in parallel with the actual steering. Newly detected information about the movement of the target and/or information about the flight of the missile is used in the optimization method as soon as the information is available. Optimized control parameters are accepted into the current parameter vector after being provided by the optimization method. An interceptor missile contains the current parameter vector and a control and evaluation unit for carrying out the method.

Abstract: Handheld device for manually actuating by a user, wherein the handheld device comprises a processing unit which is configured for processing an underground, and a sensor unit which is configured for detecting sensor data which are indicative for a condition of the underground before, during, and/or after processing the underground.

Abstract: A method (100) is proposed for operating an internal combustion engine (210), which comprises a lean-burn engine having compression-ignition, having a throttle valve (213) in an air path (212) upstream of the internal combustion engine (210) and an exhaust gas posttreatment system (202) downstream of the internal combustion engine (210), comprising a control of the internal combustion engine (210) according to a present load demand (130) using metering of an amount of fuel in dependence on the present load demand; and if a load demand (130) is absent in a heating operating mode, further comprising partially closing (140) the throttle valve (213) and defining a minimum value for the amount of fuel, which is greater than zero. Furthermore, a computing unit and a computer program for carrying out such a method (100) are proposed.

Abstract: Provided herein are methods of identifying structures, e.g., attributes, of a therapeutic protein or a target that affect an interaction between the therapeutic protein and the target. In exemplary embodiments, the method comprises: (a) applying a stress to a first sample comprising therapeutic proteins or targets; (b) contacting the first sample with a second sample comprising targets or therapeutic proteins to form a mixture comprising (i) therapeutic protein-target complexes, (ii) unbound therapeutic proteins, and (iii) unbound targets; and (c) separating the mixture into at least two fractions, wherein an unbound fraction comprises unbound therapeutic proteins or unbound targets and a bound fraction comprises therapeutic protein-target complexes; and (d) for each of the unbound fraction and bound fraction, identifying and quantifying the abundance of the structures, e.g., attribute, present on a species of the therapeutic protein or target.

Abstract: Provided herein are methods of modulating Fc gamma Receptor (Fc?R)-mediated cytotoxicity of an antibody composition. In exemplary embodiments, the method comprises (1) increasing or decreasing the amount of terminal ?-galactose at the N-297 glycosylation site of panitumumab, or increasing or decreasing the amount of panitumumab molecules that comprise G1, G1a, G1b and/or G2 galactosylated glycan at the N-297 site, (2) increasing or decreasing the amount of panitumumab molecules that comprise fucosylated glycan at the N-297 site, or increasing or decreasing the amount of panitumumab molecules that comprise afucosylated glycan at the N-297 site, and (3) increasing or decreasing the amount of panitumumab molecules that comprise a high-mannose glycan at the N-297 site.

Abstract: An internal combustion engine for a motor vehicle includes an exhaust system through which exhaust gas can flow and in which a first exhaust gas aftertreatment element is disposed. An exhaust gas turbocharger has a turbine and the turbine has a turbine wheel which is disposed upstream of the first exhaust gas aftertreatment element. A bypass line bypasses the turbine wheel and via the bypass line at least part of the exhaust gas can bypass the turbine wheel. The bypass line also bypasses the first exhaust gas aftertreatment element. The bypass line is fluidically connected to the exhaust system at a branch point disposed upstream of the turbine wheel and upstream of the first exhaust gas aftertreatment element. The bypass line is fluidically connected to the exhaust system at a discharge point disposed downstream of the turbine wheel and downstream of the first exhaust gas aftertreatment element.

Abstract: An inductive sensor, particularly for a proximity sensor, includes a resonance circuit including a sensing coil and an amplifier comprising a first gain stage and a second gain stage each coupled via respective adjusting elements with the resonance circuit to inject energy for maintaining an oscillation of the resonance circuit. The first gain stage provides a substantially linear amplification and the second gain stage provides a comparator characteristics.

Abstract: The present invention relates to an oscillating sensor for a measurement device comprising: an oscillator comprising a resonance circuit for providing an oscillation signal; a gain stage configured to feedback to the resonance circuit to inject energy for excitation of the resonance circuit to maintain oscillation; at least one calibration element to adjust the open loop gain of the oscillator; a calibration unit to provide a modulated calibration control signal to selectively adjust an electrical measure of the at least one calibration element based on at least one predetermined duty cycle, wherein the modulated calibration control signal has an irregularly time-varying cycle frequency.

Abstract: An oscillating sensor device, particularly for a proximity sensor, for sensing a dynamic change of attenuation caused by a measurable physical effect includes an oscillator including a resonance circuit and an amplifier fed back to the resonance circuit and configured to maintain oscillation of the oscillator, and a control unit configured to control the open loop gain of the oscillator. The amplifier comprises a non-linear gain characteristics defining an operating point at a preset amplitude of oscillation. The control unit is configured to control the open loop gain of the oscillator so that the operating point is set to a preset amplitude of the oscillation.

Abstract: An internal combustion engine for a motor vehicle includes an exhaust system through which exhaust gas can flow and in which a first exhaust gas aftertreatment element is disposed. An exhaust gas turbocharger has a turbine and the turbine has a turbine wheel which is disposed upstream of the first exhaust gas aftertreatment element. A bypass line bypasses the turbine wheel and via the bypass line at least part of the exhaust gas can bypass the turbine wheel. The bypass line also bypasses the first exhaust gas aftertreatment element. The bypass line is fluidically connected to the exhaust system at a branch point disposed upstream of the turbine wheel and upstream of the first exhaust gas aftertreatment element. The bypass line is fluidically connected to the exhaust system at a discharge point disposed downstream of the turbine wheel and downstream of the first exhaust gas aftertreatment element.

Abstract: For an optimized metering of fuel and water for the operation of an internal combustion engine in which a direct injection and an intake manifold injection are provided for metering fuel into the internal combustion engine, and in which the internal combustion engine is assigned a system for water injection, a same intake manifold injector is used for both water and fuel injection.

Abstract: Embodiments relate to apparatuses, methods and computer programs for controlling a machine. The apparatus is suitable for a mobile communication device for providing a sensor input signal to a machine control entity to control a machine. The apparatus comprises one or more sensor modules for providing first user input sensor data and second user input sensor data. The apparatus further comprises a control module configured to determine the sensor input signal based on the first user input sensor data and the second user input sensor data. The control module is further configured to provide the sensor input signal for sensor data processing to the machine control entity to control the machine via an interface.

Abstract: An inductive sensor, particularly for a proximity sensor, includes a resonance circuit including a sensing coil and an amplifier comprising a first gain stage and a second gain stage each coupled via respective adjusting elements with the resonance circuit to inject energy for maintaining an oscillation of the resonance circuit. The first gain stage provides a substantially linear amplification and the second gain stage provides a comparator characteristics.

Abstract: The present invention relates to an oscillating sensor for a measurement device comprising: an oscillator comprising a resonance circuit for providing an oscillation signal; a gain stage configured to feed back to the resonance circuit to inject energy for excitation of the resonance circuit to maintain oscillation; at least one calibration element to adjust the open loop gain of the oscillator; a calibration unit to provide a modulated calibration control signal to selectively adjust an electrical measure of the at least one calibration element based on at least one predetermined duty cycle, wherein the modulated calibration control signal has an irregularly time-varying cycle frequency.