Abstract: The present invention relates to a phosphatidylserine (PS) binding agents comprising one or more C-domains of a milk fat globule-EGF factor 8 (MFG-E8) protein, and methods of making and using the same.

Abstract: A method is for reducing an energy demand and/or energy consumption by a vehicle, in particular a motor vehicle. The vehicle includes a steering system having at least two wheel steering angle actuators for changing a respective wheel steering angle of a vehicle wheel on an individual wheel basis, and a vehicle sensor system for driving situation recognition. In at least one operating state, in which a predefined driving situation is identified using the vehicle sensor system, a power consumption by at least one wheel steering angle actuator is reduced in order to reduce the energy demand and/or energy consumption, in particular such that the power consumption by the at least one wheel steering angle actuator is below a power consumption by the at least one wheel steering angle actuator planned for in the identified predefined driving situation.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: The method relates to a press-hardened component with a tensile strength Rm>1600 MPa, in particular >1800 MPa, and especially >2000 MPa, wherein the component is manufactured from a steel material, wherein the steel material is a boron-manganese steel, which has a carbon content >0.30 mass %, wherein the steel material is hot rolled or hot rolled and cold rolled to a strip with a thickness of 0.5 to 3 mm, wherein the strip has a thin coating of zinc or a zinc-based alloy and a coating weight of <50 g/m2 on each strip side of the steel strip.

Abstract: A method for influencing a stiffness behavior of a vehicle assembly of a vehicle includes changing a wheel steering angle of at least one vehicle wheel of the vehicle using at least one wheel steering angle controller of a steering system of the vehicle, and reducing a stiffness of the vehicle assembly by configuring and/or adapting a chassis characteristic of the vehicle. The method further includes actuating the at least one wheel steering angle controller in at least one driving mode state to selectively influence the stiffness behavior of the vehicle assembly, such that a change in the stiffness of the vehicle assembly caused by the configuration and/or adaptation of the chassis characteristic is compensated as a function of a driving situation.

Abstract: A method for calibrating an actuation of a converter lock-up clutch of a hydrodynamic torque converter having a pump wheel and a turbine wheel connected to a power-split transmission. The transmission has at least two clutches each connected to a respective power-split shaft assembly and each configured be actuated separately to close and open in order to apply a clutch torque to the turbine wheel so that a rotation speed difference between the pump wheel and the turbine wheel changes. The method includes opening the converter lock-up clutch and the at least two clutches each connected to a respective power-split shaft assembly of the transmission, rotating the pump wheel with a specified rotation speed, and applying a clutch torque to the turbine wheel as a function of an actual rotation speed difference. Clutches connected to a different respective power-split shaft assembly of the transmission are actuated in the closing direction.

Abstract: A method for holding a vehicle on a gradient. The vehicle has a transmission with an output, a first clutch and a second clutch. The primary sides of the first and second clutches are mechanically operatively connected to one another. The secondary sides of the first and second clutches are mechanically operatively connected to one another and to the output of the transmission. Different transmission ratios can be engaged by way of the first clutch and the second clutch, and the first clutch is in an engaged state. The method includes the additional closure of the second clutch in order to block the transmission and thus hold the vehicle at a standstill on a gradient.

Abstract: The invention relates to a method for producing a sheet steel component by means of a press hardening or form hardening process, the sheet steel component being produced by virtue of the fact that a sheet bar composed of at least one region made of a highly hardenable carbon/manganese/boron steel and at least one dual-phase steel is cold-formed, then heated, and then quenched in a cooling press or a sheet bar composed of at least one region made of a highly hardenable carbon/manganese/boron steel and at least one region made of a dual-phase steel is heated to a temperature above the austenitization temperature of the highly hardenable steel material and is then formed into the sheet steel component in a single stroke or in a plurality of strokes in a forming and cooling press, wherein as a softer material and as a partner for the highly hardenable carbon/manganese/boron steel, a dual-phase steel is used, whose Ac3 value is increased until at the required annealing temperatures, with the austenitization of the

Abstract: A method of shifting a transmission in which a clutch, located in the torque flow, in a first gear and in a second gear is controlled in such manner that, in the first gear, the clutch slips and transmits a first torque and, in the second gear, the clutch slips and transmits a second torque. The second torque is chosen such that an output torque of the transmission remains the same when shifting from the first gear to the second gear.

Abstract: The invention relates to a method for producing an ultra-high-strength hot-rolled structural steel, wherein a steel is produced with a carbon content that is not greater than 0.

Abstract: A control unit (11) that outputs a shift signal to a transmission (4) when the control unit recognizes that the bucket (1) is in a loading position, such that the transmission (4) shifts not to the next-higher gear ratio, but to a further, even higher, gear ratio.

Abstract: A method for holding a vehicle on a gradient. The vehicle has a transmission with an output, a first clutch and a second clutch. The primary sides of the first and second clutches are mechanically operatively connected to one another. The secondary sides of the first and second clutches are mechanically operatively connected to one another and to the output of the transmission. Different transmission ratios can be engaged by way of the first clutch and the second clutch, and the first clutch is in an engaged state. The method includes the additional closure of the second clutch in order to block the transmission and thus hold the vehicle at a standstill on a gradient.

Abstract: The invention relates to a method for producing a sheet steel component by means of a press hardening or form hardening process, the sheet steel component being produced by virtue of the fact that a sheet bar composed of at least one region made of a highly hardenable carbon/manganese/boron steel and at least one dual-phase steel is cold-formed, then heated, and then quenched in a cooling press or a sheet bar composed of at least one region made of a highly hardenable carbon/manganese/boron steel and at least one region made of a dual-phase steel is heated to a temperature above the austenitization temperature of the highly hardenable steel material and is then formed into the sheet steel component in a single stroke or in a plurality of strokes in a forming and cooling press, wherein as a softer material and as a partner for the highly hardenable carbon/manganese/boron steel, a dual-phase steel is used, whose Ac3 value is increased until at the required annealing temperatures, with the austenitization of the

Abstract: A method for controlling the transmission of a working machine, by which, with at least one sensor of the working machine, at least one specific parameter is determined and transmitted to a control unit for controlling the transmission. The working machine has a lifting mechanism and the at least one specific parameter which characterizes an actuation condition of the lifting mechanism. A predetermined shifting strategy is adapted, by the method, as a function of the at least one specific parameter.

Abstract: The invention relates to a method for producing a sheet steel component by means of a press hardening or form hardening process, the sheet steel component being produced by virtue of the fact that a sheet bar composed of a dual-phase steel is cold-formed, then heated, and then quenched in a cooling press or a sheet bar composed of a dual-phase steel is heated to a temperature above the austenitization temperature of the highly hardenable steel material and is then formed into the sheet steel component in a single stroke or in a plurality of strokes in a forming and cooling press, wherein a dual-phase steel is used, whose Ac3 value is increased until at the required annealing temperatures, only a partial austenitization of the dual-phase steel takes place so that when loaded into the cooling press, the dual-phase steel has a ferritic matrix, and in addition to this, austenite is present.

Abstract: A method of shifting a transmission in which a clutch, located in the torque flow, in a first gear and in a second gear is controlled in such manner that, in the first gear, the clutch slips and transmits a first torque and, in the second gear, the clutch slips and transmits a second torque. The second torque is chosen such that an output torque of the transmission remains the same when shifting from the first gear to the second gear.

Abstract: A method for controlling the transmission of a working machine, by which, with at least one sensor of the working machine, at least one specific parameter is determined and transmitted to a control unit for controlling the transmission. The working machine has a lifting mechanism and the at least one specific parameter which characterizes an actuation condition of the lifting mechanism. A predetermined shifting strategy is adapted, by the method, as a function of the at least one specific parameter.

Abstract: A steel sheet for hot pressing includes in a chemical composition, in percent by mass, C of 0.1% to 0.4%, Si of greater than 0% to 2.0%, Mn of 0.5% to 3.0%, P of greater than 0% to 0.015%, S of greater than 0% to 0.01%, B of 0.0003% to 0.01%, N of greater than 0% to 0.05%, Al in a content of 2×[N]% to 0.3% at a Si content of greater than 0.5% to 2.0%; or Al in a content of (0.20+2×[N]?0.40×[Si]N)% to 0.3% at a Si content of 0% to 0.5%, where [N] and [Si] are contents of N and Si, respectively, in mass percent, with the remainder being iron and inevitable impurities, where contents of Ti, Zr, Hf, and Ta, of the inevitable impurities, are each controlled to 0.005% or lower. The steel sheet includes nitride-based inclusions with an equivalent circle diameter of 1 ?m or more in a number density of 0.10 per square millimeter.

Abstract: A control unit (11) that outputs a shift signal to a transmission (4) when the control unit recognizes that the bucket (1) is in a loading position, such that the transmission (4) shifts not to the next-higher gear ratio, but to a further, even higher, gear ratio.

Abstract: A method for calibrating a characteristic diagram for a drive-train of a working machine, which contains a brake pedal characteristic of a brake system and a clutch characteristic of a drive clutch, in which an opening point at which the drive clutch is disengaged when a brake pedal of the brake system is actuated as a function of a pedal path, and/or a closing point at which the drive clutch is engaged when the brake pedal is released as a function of the pedal path, is calibrated. When the brake pedal is actuated and/or released an actual rotational speed profile of the drive-train is determined, the actual rotational speed profile determined is compared with a stored corresponding target rotational speed profile, and the opening point and/or closing point of the drive clutch is adapted to minimize deviation of the actual rotational speed profile from the target rotational speed profile.