Patents by Inventor Thomas L. Fevig

Thomas L. Fevig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fungicidal compositions and methods of making thereof
    Patent number: 6291513
    Abstract: The fungicidal compound 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide (Formula (I)) has shown superior and unexpected control of the growth of the soil-borne fungus Gaeumannomyces graminis (Gg). The present invention provides a novel compound for synthesizing the compound of Formula (I) which uses the compound 4-hydroxy-4,5-dimethyl-2-trimethylsilanyl-dihydrothiophene-3-carboxylic acid allylamide (Formula (II)) as well as novel compounds of synthesizing the allylamide. In addition, Formula (II) itself has unexpectedly been found to provide control of Gg.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: September 18, 2001
    Assignee: Monsanto company
    Inventors: Wendell G. Phillips, Michael K. Mao, Chun Ma, Thomas L. Fevig
  • Fungicidal compositions and methods of making thereof
    Patent number: 6140511
    Abstract: The fungicidal compound 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide (Formula (I) shown superior and unexpected control of the growth of the soil-borne fungus Gaeumannomyces graminis (Gg). The present invention provides a novel compound for synthesizing the compound of Formula (I) which uses the compound 4-hydroxy-4,5-dimethyl-2-trimethylsilanyl-dihydrothiophene-3-carboxylic acid allylamide (Formula (II)) as well as novel compounds of synthesizing the allylamide. In addition, Formula (II) itself has unexpectedly been found to provide control of Gg. Therefore, the compounds having Formula (III): ##STR1## or an agronomic salts and compositions thereof are expected to provide such control as well; wherein:Q is --NH, S, or O;W is O, or S;X is --OH, --OAc, --OR, where R is lower alkyl;Y is S, O, or --NH;Z is --Si(R).sub.3, --C(R).sub.3, where R is lower alkyl;R.sub.1 is a lower alkyl, allyl, or propargyl;R.sub.2 is a lower alkyl or aryl; andR.sub.3 and R.sub.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: October 31, 2000
    Assignee: Monsanto Company
    Inventors: Wendell G. Phillips, Michael K. Mao, Chun Ma, Thomas L. Fevig
  • Synthesis of 3-carbomethoxy-4,5-dimethylthiophene
    Patent number: 6084108
    Abstract: Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: July 4, 2000
    Assignee: Monsanto Company
    Inventors: Thomas L. Fevig, Patrick H. Lau, Wendell G. Phillips
  • Synthesis of 3-carbomethoxy-4,5-dimethylthiophene
    Patent number: 6037478
    Abstract: Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: March 14, 2000
    Assignee: Monsanto Company
    Inventors: Thomas L. Fevig, Patrick H. Lau, Wendell G. Phillips
  • Cyclic nitrones
    Patent number: 5962469
    Abstract: The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 5, 1999
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Craig E. Thomas, Thomas L. Fevig, Stephen M. Bowen, Robert A. Farr, Albert A. Carr, David A. Janowick
  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5529995
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: June 25, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum
  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5488048
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: January 30, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum
  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5424425
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: June 13, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum