Abstract: A thermoplastic polyurethane (TPU) elastomer and p-phenylene diisocyanate (PPDI)/polycaprolactone-based composition therefor having a unique chain extender combination for improved injection moldability. The elastomer is formed as the reaction product of: (A) from about 60 to 80% by weight of a hydroxyl-terminated poly(caprolactone) diol; (B) from about 17 to 22% by weight of a p-phenylene diisocyanate; (C) from about 3 to 10% by weight of a first hydroxyl-functional chain extender; and (D) less than about 2% by weight of a second hydroxyl-functional chain extender different from the first chain extender, the second chain extender being selected as effective to modify the crystallinity of the elastomer.

Abstract: A thermoplastic polyurethane (TPU) elastomer and p-phenylene diisocyanate (PPDI)/polycaprolactone-based composition therefor having a unique chain extender combination for improved injection moldability. The elastomer is formed as the reaction product of: (A) from about 60 to 80% by weight of a hydroxyl-terminated poly(caprolactone) diol; (B) from about 17 to 22% by weight of a p-phenylene diisocyanate; (C) from about 3 to 10% by weight of a first hydroxyl-functional chain extender; and (D) less than about 2% by weight of a second hydroxyl-functional chain extender different from the first chain extender, the second chain extender being selected as effective to modify the crystallinity of the elastomer.

Abstract: A fluid retention assembly for use in association with an iontophoretic drug delivery device comprising: a matrix, wherein the matrix is fabricated from a hydroxylated polyvinyl acetal; a first excipient associated with the matrix, wherein the first excipient comprises a substantially non-ionic thickening agent; and a second excipient associated with the matrix, wherein the second excipient comprises a hydration enhancer. A method for preparing a fluid retention assembly for use in association with an iontophoretic drug delivery device comprising the steps of: providing a first excipient, wherein the first excipient comprises a substantially non-ionic thickening agent; providing a second excipient, wherein the second excipient comprises a hydration enhancer; preparing a solution of the first and second excipients in a solvent; soaking a matrix fabricated from a hydroxylated polyvinyl acetal in the prepared solution; and drying the matrix.

Abstract: A thermoplastic polyurethane (TPU) elastomer and p-phenylene diisocyanate (PPDI)/polycaprolactone-based composition therefor having a unique chain extender combination for improved injection moldability. The elastomer is formed as the reaction product of: (A) from about 60 to 80% by weight of a hydroxyl-terminated poly(caprolactone) diol; (B) from about 17 to 22% by weight of a p-phenylene diisocyanate; (C) from about 3 to 10% by weight of a first hydroxyl-functional chain extender; and (D) less than about 2% by weight of a second hydroxyl-functional chain extender different from the first chain extender, the second chain extender being selected as effective to modify the crystallinity of the elastomer.

Abstract: A fluid retention assembly for use in association with an iontophoretic drug delivery device comprising: a matrix, wherein the matrix is fabricated from a hydroxylated polyvinyl acetal; a first excipient associated with the matrix, wherein the first excipient comprises a substantially non-ionic thickening agent; and a second excipient associated with the matrix, wherein the second excipient comprises a hydration enhancer.