Patents by Inventor Thomas L. Schwarz

Thomas L. Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neuronal survival and axonal regeneration through increasing mitochondrial motility
    Patent number: 11413325
    Abstract: Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 16, 2022
    Assignee: THE CHILDREN'S MEDICAL CENTER
    Inventors: Zhigang He, Thomas L. Schwarz, Cartoni Romain
  • NEURONAL SURVIVAL AND AXONAL REGENERATION THROUGH INCREASING MITOCHONDRIAL MOTILITY
    Publication number: 20200061154
    Abstract: Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.
    Type: Application
    Filed: December 7, 2017
    Publication date: February 27, 2020
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Zhigang HE, Thomas L. SCHWARZ, Cartoni ROMAIN
  • Photocleavable Chemical Inducers of Dimerization (CID) and Methods of Use
    Publication number: 20190284164
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Application
    Filed: August 20, 2018
    Publication date: September 19, 2019
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick
  • Photocleavable chemical inducers of dimerization (CID) and methods of use
    Patent number: 10053445
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 21, 2018
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick
  • PHOTOCLEAVABLE CHEMICAL INDUCERS OF DIMERIZATION (CID) AND METHODS OF USE
    Publication number: 20160272618
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Application
    Filed: October 24, 2014
    Publication date: September 22, 2016
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick