Patents by Inventor Thomas L. Smestad
Thomas L. Smestad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5643464Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.Type: GrantFiled: June 30, 1995Date of Patent: July 1, 1997Assignee: Collagen CorporationInventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Schroeder, Larry J. Braga, Thomas L. Smestad, Abigail Freeman
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Patent number: 5550187Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.Type: GrantFiled: August 8, 1994Date of Patent: August 27, 1996Assignee: Collagen CorporationInventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Tefft, Larry J. Braga, Thomas L. Smestad
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Patent number: 5527856Abstract: The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention am also disclosed.Type: GrantFiled: May 12, 1995Date of Patent: June 18, 1996Assignee: Collagen CorporationInventors: Woonza M. Rhee, Richard A. Berg, Joel S. Rosenblatt, Jacqueline A. Tefft, Larry J. Braga, Thomas L. Smestad
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Patent number: 5425770Abstract: Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.Type: GrantFiled: July 30, 1993Date of Patent: June 20, 1995Assignee: Collagen CorporationInventors: Karl A. Piez, Bruce B. Pharriss, George H. Chu, Thomas L. Smestad, Diana Hendricks
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Patent number: 5383930Abstract: A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 to 50 mg/ml and the suspension exhibiting an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 5 to 30 newtons.Type: GrantFiled: November 2, 1992Date of Patent: January 24, 1995Assignee: Collagen CorporationInventors: Ann Brannan, Roseann Burhenne, Frank A. Delustro, Thomas L. Smestad, Louis Fries, Rees M. Orland
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Patent number: 5366498Abstract: A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 to 50 mg/ml and the suspension exhibiting an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 5 to 30 newtons.Type: GrantFiled: February 10, 1993Date of Patent: November 22, 1994Assignee: Collagen CorporationInventors: Ann Brannan, Roseann Burhenne, Frank A. Delustro, Thomas L. Smestad, Louis Fries, Rees M. Orland
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Patent number: 5246457Abstract: A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.Type: GrantFiled: December 17, 1990Date of Patent: September 21, 1993Assignee: Collagen CorporationInventors: Karl A. Piez, Bruce B. Pharriss, George H. Chu, Thomas L. Smestad, Diana Hendricks
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Patent number: 5123925Abstract: The present invention is a method for treating bony defects. The method involves contacting the bony defect with a formable composition and allowing the formable composition to solidify. The formable composition is comprised of 2-40% of reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight exclusive of moisture. After the formable composition is placed in intimate contact with the bony defect, it is allowed to solidify until it acquires an additional characteristic selected from the group consisting of a compressive modulus of at 10 N/cm.sup.2 or a tensile strength of at least 1 N/cm.sup.2. The method can be used to repair a variety of bony defects such as bone non-union, fresh fractures, periodontal bony pockets, tooth extraction sockets and jaw cysts. Further, the composition can be used to augment an alveolar ridge.Type: GrantFiled: January 29, 1991Date of Patent: June 23, 1992Assignee: Collagen CorporationInventors: Thomas L. Smestad, Daniel Prows, George H. Chu, Diana M. Hendericks, Debera Brown
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Patent number: 5035715Abstract: A biocompatible collagen/mineral composition which comprises a mixture of 2-40% reconstituted fibrillar atelopeptide collagen and 60-98% calcium phosphate mineral by weight, exclusive of water, is disclosed. The composition has a sterility assurance factor of at least as low as 10.sup.-6 and either a compressive modulus of at least 10 N/cm.sup.-2 or a tensile strength of about 3-12 N/cm.sup.-2.Type: GrantFiled: May 24, 1989Date of Patent: July 30, 1991Assignee: Collagen CorporationInventors: Thomas L. Smestad, Daniel Prowse, George H. Chu, Diana M. Hendricks
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Patent number: 4992226Abstract: A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.Type: GrantFiled: September 16, 1988Date of Patent: February 12, 1991Assignee: Collagen CorporationInventors: Karl A. Piez, Bruce B. Pharriss, George H. Chu, Thomas L. Smestad, Diana Hendricks
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Patent number: 4865602Abstract: A process for sterilization of collagen/mineral compositions using .gamma. radiation is conducted under conditions which produce a product of desired handling and biocompatibility properties.Type: GrantFiled: November 6, 1986Date of Patent: September 12, 1989Assignee: Collagen CorporationInventors: Thomas L. Smestad, Daniel Prows, George H. Chu, Diana M. Hendricks
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Patent number: 4795467Abstract: A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.Type: GrantFiled: April 4, 1986Date of Patent: January 3, 1989Assignee: Collagen CorporationInventors: Karl A. Piez, Bruce B. Pharriss, George H. Chu, Thomas L. Smestad, Diana Hendricks
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Patent number: 4789663Abstract: A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.Type: GrantFiled: July 5, 1985Date of Patent: December 6, 1988Assignee: Collagen CorporationInventors: Donald G. Wallace, Thomas L. Smestad, John M. McPherson, Karl A. Piez, Saeid Seyedin, Rosa Armstrong
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Patent number: 4582640Abstract: Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous medium at a concentration of 0.1 to 10 mg/ml with glutaraldehyde under conditions that produce cross-linked collagen that when in suspension in physiological saline at a concentration of 35 mg/ml exhibits a shear viscosity whose log varies linearly with the log of the shear rate and is approximated by the formulalog .eta..ltoreq.-0.96 log .gamma.+2.3where .gamma. is the shear rate in sec.sup.-1, log .gamma. is in the range of -6 to +2 and .eta. is the viscosity of the suspension in Pascal-sec; optionally quenching the cross-linking reaction with an amino acid; and separating the cross-linked atelopeptide collagen from the reaction mixture.Type: GrantFiled: October 22, 1984Date of Patent: April 15, 1986Assignee: Collagen CorporationInventors: Thomas L. Smestad, John McPherson, Donald G. Wallace
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Patent number: 4430760Abstract: A flexible, nonstress-bearing bone prosthesis is disclosed that comprises demineralized bone powder contained within a medical grade porous flexible casing made from polymeric fibers or a micro-porous membrane. The pores of the casing are smaller than the particle size of the bone powder but large enough to permit ingress of body cells associated with bone formation.Type: GrantFiled: December 18, 1981Date of Patent: February 14, 1984Assignee: Collagen CorporationInventor: Thomas L. Smestad