Patents by Inventor Thomas LaFramboise

Thomas LaFramboise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20240068045
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
    Type: Application
    Filed: October 19, 2023
    Publication date: February 29, 2024
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Amitabh Chak
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20220154294
    Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
    Type: Application
    Filed: February 2, 2022
    Publication date: May 19, 2022
    Inventors: Sanford D. Markowitz, Helen Moinova, Amitabh Chak, Joseph Willis, Thomas LaFramboise
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20190309372
    Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.
    Type: Application
    Filed: July 5, 2017
    Publication date: October 10, 2019
    Inventors: Sanford D. Markowitz, Helen Moinova, Amitabh Chak, Joseph Willis, Thomas LaFramboise
  • METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS
    Publication number: 20190136325
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially/methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.
    Type: Application
    Filed: December 30, 2015
    Publication date: May 9, 2019
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Amitabh Chak
  • METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS
    Publication number: 20170369948
    Abstract: The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 28, 2017
    Applicant: Case Western Reserve University
    Inventors: Sanford D. Markowitz, Joseph E. Willis, Helen Moinova, Thomas LaFramboise, Omar de la Cruz Cabrera, Ryan Fecteau