Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.

Abstract: A method for continuous production of hydroxyazapirones, for example 6-hydroxybuspirone, using a modified reactor. The products of the invention are useful as pharmaceutical agents.

Abstract: The geometry of the reactor is tailored to increase the heat transfer capacity of the initial sections of the reactor columns where the greatest heat is generated. This is accomplished by reducing the inner diameter of the initial column sections relative to that of the final column sections and by increasing the rate of heat transfer from to the coolant proximate the initial column sections by increasing the velocity of coolant surrounding the initial column sections. Further, the coolant flow is directed in a direction perpendicular to the axis of each column by spaced, laterally offset baffles.

Abstract: A two-position contoured, externally mounted rear view mirror for automotive vehicles as disclosed. The mirror housing is rotatable between two fixed positions. The mirror housing contains a first relatively large mirror providing a relatively large rearward viewing area for city driving and a second relatively smaller mirror having a reduced rearward viewing area for highway driving. In a first fixed position of the mirror housing, the first mirror is viewable by the operator and in a second fixed position, the second mirror is viewable by the operator. The mirror housing is shaped such that in the second position, the aerodynamic drag of the mirror housing is minimized to improve the high speed efficiency of the vehicle. Alternate embodiments of the invention include convex portions for the mirror to increase the rearward field of view.