Patents by Inventor Thomas Larsen
Thomas Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132807Abstract: The present invention relates to novel protease variants exhibiting improved stability and or improved wash performance in liquid detergent. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.Type: ApplicationFiled: December 30, 2023Publication date: April 25, 2024Applicant: NOVOZYMES A/SInventors: Miguel Duarte Guilherme Pereira Toscano, Esben Peter Friis, Rolf Thomas Lenhard, Signe Eskildsen Larsen, Astrid Munch, Bena-Marie Lue, Mikael Bauer
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Patent number: 11952558Abstract: The present invention relates to novel protease variants exhibiting improved stability and or improved wash performance in liquid detergent. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.Type: GrantFiled: April 6, 2021Date of Patent: April 9, 2024Assignee: NOVOZYMES A/SInventors: Miguel Duarte Guilherme Pereira Toscano, Esben Peter Friis, Rolf Thomas Lenhard, Signe Eskildsen Larsen, Astrid Munch, Bena-Marie Lue, Mikael Bauer
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Publication number: 20180094005Abstract: A method is useful for forming a product including a cyclic siloxane compound. The method includes combining an organodihalosilane and a transition metal on cerium (IV) oxide catalyst, in a reactor at a temperature of to form the product.Type: ApplicationFiled: April 1, 2016Publication date: April 5, 2018Inventors: Dimitris Katsoulis, Robert Thomas Larsen, Matthew J Mclaughlin, Vladimir Pushkarev
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Patent number: 9321793Abstract: The present invention relates to a method for separating organohalosilanes. The method includes introducing a mixture including at least a first organohalosilane and a second organohalosilane onto a chromatographic bed including a stationary phase. The method also includes passing a liquid mobile phase through the chromatographic bed to produce an eluate including at least one fraction enriched in the first organohalosilane and at least one fraction enriched in the second organohalosilane.Type: GrantFiled: May 1, 2013Date of Patent: April 26, 2016Assignee: Dow Corning CorporationInventors: Robert Thomas Larsen, Michael W. Toepke
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Patent number: 9108941Abstract: The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).Type: GrantFiled: December 22, 2009Date of Patent: August 18, 2015Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTSInventors: Alwin Kraemer, Blanka Leber, Mads Clausen, Thomas Larsen, Mads Roennest, Kasper Worm
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Patent number: 9073951Abstract: A method of preparing organohalosilanes comprising combining an organohalide having the formula RX (I), wherein R is a hydrocarbyl group having 1 to 10 carbon atoms and X is fluoro, chloro, bromo, or iodo, with a contact mass comprising at least 2% (w/w) of a palladium suicide of the formula PdxSiy (II), wherein x is an integer from 1 to 5 and y is 1 to 8, or a platinum suicide of formula PtzSi (III), wherein z is 1 or 2, in a reactor at a temperature from 250 to 700° C. to form an organohalosilane.Type: GrantFiled: January 24, 2011Date of Patent: July 7, 2015Assignee: Dow Corning CorporationInventors: Kurt E. Anderson, Aswini K. Dash, Charles Alan Hall, Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Jonathan David Wineland
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Publication number: 20150141688Abstract: The present invention relates to a method for separating organohalosilanes. The method includes introducing a mixture including at least a first organohalosilane and a second organohalosilane onto a chromatographic bed including a stationary phase. The method also includes passing a liquid mobile phase through the chromatographic bed to produce an eluate including at least one fraction enriched in the first organohalosilane and at least one fraction enriched in the second organohalosilane.Type: ApplicationFiled: May 1, 2013Publication date: May 21, 2015Applicant: Dow Corning CorporationInventors: Robert Thomas Larsen, Michael W. Toepke
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Patent number: 8859709Abstract: A mixture of at least two polyhedral oligomeric silsesquioxane (POSS) compounds is formed in the presence of rhenium on cerium(IV) oxide. The POSS compounds are formed utilizing a method that includes the step of combining (a) a trihalosilane, (b) hydrogen gas, and (c) the rhenium on cerium(IV) oxide, in a reactor at a temperature of from 250° C. to 600° C. to form the mixture. The trihalosilane has the formula RSiX3 wherein R is an alkyl group having from 1 to 4 carbon atoms, an aryl group, and wherein X is a halo atom. This method allows for the efficient, predictable, and accurate production of the POSS compounds with a minimized need for use of expensive separation techniques. In addition, this method produces the POSS compounds in commercially useful quantities as major reaction products thereby avoiding the need to run multiple reactions.Type: GrantFiled: December 22, 2011Date of Patent: October 14, 2014Assignee: Dow Corning CorporationInventors: Dimitris Katsoulis, Robert Thomas Larsen
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Patent number: 8765090Abstract: A method of preparing a trihalosilane comprising the separate and consecutive steps of (i) contacting a copper catalyst with hydrogen gas and a silicon tetrahalide at a temperature of from 500 to 1400° C. to form a silicon-containing copper catalyst comprising at least 0.1% (w/w) of silicon, wherein the copper catalyst comprises a metal selected from copper and a mixture comprising copper and at least one element selected from gold, magnesium, and platinum; and (ii) contacting the silicon-containing copper catalyst with a hydrogen halide at a temperature of from 100 to 600° C. to form a trihalosilane.Type: GrantFiled: August 25, 2011Date of Patent: July 1, 2014Assignee: Dow Corning CorporationInventors: Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Wendy Sparschu
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Publication number: 20140138577Abstract: A mixture of at least one polysilane and at least one polycarbosilane is formed in the presence of a metal silicide. The mixture is formed utilizing a method that includes the step of combining the metal silicide and an alkyl halide in a reactor at a temperature of from 200° C. to 600° C. The alkyl halide has the formula RX, wherein R is C1-C10 alkyl and X is halo. This method forms high yield mixtures of the at least one polysilane and the at least one polycarbosilane. Additionally, the mixture is time and cost effective and allows the mixture to be formed in a predictable and controlled manner. Moreover, the components used in this method can be easily recycled and/or re-used in other processes.Type: ApplicationFiled: June 14, 2012Publication date: May 22, 2014Applicant: Dow Corning CorporationInventors: Dimitris Elias Katsoulis, Robert Thomas Larsen
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Patent number: 8722915Abstract: A process for preparing organohalosilanes comprising combining hydrogen, a halosilane having the formula HaSiX4-a (I) and an organohalide having the formula RX (II), wherein R is C1-C10 alkyl or C4-C10 cycloalkyl, each X is independently halo, and the subscript a is 0, 1, or 2, in the presence of a sufficient amount of a catalyst effective in enabling the replacement of one or more of the halo groups of the halosilane with the R group from the organohalide, at a temperature from 200 to 800° C., to form an organohalosilane and a hydrogen halide, wherein the volumetric ratio of hydrogen to halosilane is from 1:3 to 1:0.001 and the volumetric ratio of hydrogen to organohalide is from 1:1 to 1:0.001, and wherein the catalyst is optionally treated with the hydrogen or the halosilane prior to the combining.Type: GrantFiled: April 6, 2011Date of Patent: May 13, 2014Assignee: Dow Corning CorporationInventors: Aswini K. Dash, Charles Alan Hall, Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Jonathan David Wineland
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Publication number: 20130284973Abstract: A mixture of at least two polyhedral oligomeric silsesquioxane (POSS) compounds is formed in the presence of rhenium on cerium(IV) oxide. The POSS compounds are formed utilizing a method that includes the step of combining (a) a trihalosilane, (b) hydrogen gas, and (c) the rhenium on cerium(IV) oxide, in a reactor at a temperature of from 250° C. to 600° C. to form the mixture. The trihalosilane has the formula RSiX3 wherein R is an alkyl group having from 1 to 4 carbon atoms, an aryl group, and wherein X is a halo atom. This method allows for the efficient, predictable, and accurate production of the POSS compounds with a minimized need for use of expensive separation techniques. In addition, this method produces the POSS compounds in commercially useful quantities as major reaction products thereby avoiding the need to run multiple reactions.Type: ApplicationFiled: December 22, 2011Publication date: October 31, 2013Applicant: Dow Corning CorporationInventors: Dimitris Katsoulis, Robert Thomas Larsen
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Patent number: 8478986Abstract: A method is provided for establishing a split-terminated secure communication connection between a client and a server. A first network intermediary intercepts a secure communication connection request directed from the client to the server. A second intermediary having a digital certificate in the name of the server (and a corresponding private key) acts in place of the server to establish a first secure communication session with the client, during which it receives a secret from the client for generating the session key. The second intermediary supplies the secret and/or the session key to the first intermediary, which allows the first intermediary to establish follow-on secure communication sessions in which the secret is reused. The second intermediary may also supply the first intermediary with a copy of its certificate so that it can respond to new secure communication requests and, yet further, may also supply a copy of the private key.Type: GrantFiled: December 3, 2008Date of Patent: July 2, 2013Assignee: Riverbed Technology, Inc.Inventors: Shashidhar Merugu, Case Thomas Larsen, Naveen Maveli
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Publication number: 20130156676Abstract: A method of preparing a trihalosilane comprising the separate and consecutive steps of (i) contacting a copper catalyst with hydrogen gas and a silicon tetrahalide at a temperature of from 500 to 1400° C. to form a silicon-containing copper catalyst comprising at least 0.1% (w/w) of silicon, wherein the copper catalyst comprises a metal selected from copper and a mixture comprising copper and at least one element selected from gold, magnesium, and platinum; and (ii) contacting the silicon-containing copper catalyst with a hydrogen halide at a temperature of from 100 to 600° C. to form a trihalosilane.Type: ApplicationFiled: August 25, 2011Publication date: June 20, 2013Inventors: Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Wendy Sparschu
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Patent number: 8438628Abstract: A method and apparatus are provided for split-terminating a secure client-server communication connection, with client authentication. During handshaking between the client and the server, cooperating network intermediaries relay the handshaking messages, without altering the messages. At least one of the intermediaries possesses a private key of the server, and extracts a set of data fields from the handshaking messages, including a Client-Key-Exchange message that can be decrypted with the private key. The intermediary uses the extracted data to compute the client-server session key separate from the client's and the server's similar computation, and may transmit the key to the other intermediary via a secure communication channel. The client and the server thus establish the end-to-end client-server connection, and may authenticate each other, after which the network intermediaries may intercept and optimize the client-server communications transparently to the client and the server.Type: GrantFiled: June 29, 2010Date of Patent: May 7, 2013Assignee: Riverbed Technology, Inc.Inventors: Paras Shah, Case Thomas Larsen, Shashidhar Merugu, Yongsub Nam
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Publication number: 20130060060Abstract: A process for preparing organohalosilanes comprising combining hydrogen, a halosilane having the formula HaSiX4-a (I) and an organohalide having the formula RX (II), wherein R is C1-C10 alkyl or C4-C10 cycloalkyl, each X is independently halo, and the subscript a is 0, 1, or 2, in the presence of a sufficient amount of a catalyst effective in enabling the replacement of one or more of the halo groups of the halosilane with the R group from the organohalide, at a temperature from 200 to 800° C., to form an organohalosilane and a hydrogen halide, wherein the volumetric ratio of hydrogen to halosilane is from 1:3 to 1:0.001 and the volumetric ratio of hydrogen to organohalide is from 1:1 to 1:0.001, and wherein the catalyst is optionally treated with the hydrogen or the halosilane prior to the combining.Type: ApplicationFiled: April 6, 2011Publication date: March 7, 2013Inventors: Aswini K. Dash, Charles Alan Hall, Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Jonathan David Wineland
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Publication number: 20120289730Abstract: A method of preparing organohalosilanes comprising combining an organohalide having the formula RX (I), wherein R is a hydrocarbyl group having 1 to 10 carbon atoms and X is fluoro, chloro, bromo, or iodo, with a contact mass comprising at least 2% (w/w) of a palladium suicide of the formula PdxSiy (II), wherein x is an integer from 1 to 5 and y is 1 to 8, or a platinum suicide of formula Pt2Si (III), wherein z is 1 or 2, in a reactor at a temperature from 250 to 700° C. to form an organohalosilane.Type: ApplicationFiled: January 24, 2011Publication date: November 15, 2012Inventors: Kurt E. Anderson, Aswini K. Dash, Charles Alan Hall, Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. Mclaughlin, Jonathan David Wineland
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Publication number: 20120035200Abstract: The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the manufacture of a pharmaceutical composition for the treatment of cancer, and to methods of treatment for said diseases employing a compound of formula (I).Type: ApplicationFiled: December 22, 2009Publication date: February 9, 2012Applicant: Deutsches Krebsforschungszentrum Stiftung des offentlichen RechtsInventors: Alwin Kraemer, Blanka Leber, Mads Clausen, Thomas Larsen, Mads Roennest, Kasper Worm
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Publication number: 20100299525Abstract: A method and apparatus are provided for split-terminating a secure client-server communication connection, with client authentication. During handshaking between the client and the server, cooperating network intermediaries relay the handshaking messages, without altering the messages. At least one of the intermediaries possesses a private key of the server, and extracts a set of data fields from the handshaking messages, including a Client-Key-Exchange message that can be decrypted with the private key. The intermediary uses the extracted data to compute the client-server session key separate from the client's and the server's similar computation, and may transmit the key to the other intermediary via a secure communication channel. The client and the server thus establish the end-to-end client-server connection, and may authenticate each other, after which the network intermediaries may intercept and optimize the client-server communications transparently to the client and the server.Type: ApplicationFiled: June 29, 2010Publication date: November 25, 2010Applicant: RIVERBED TECHNOLOGY, INC.Inventors: Paras Shah, Case Thomas Larsen, Shashidhar Merugu, Yongsub Nam
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Patent number: RE46657Abstract: A method of making a trihalosilane comprising contacting an organotrihalosilane according to the formula RS1X3 (I), wherein R is C1-C10 hydrocarbyl and each X independently is halo, with hydrogen, wherein the mole ratio of the organotrihalosilane to hydrogen is from 0.009:1 to 1:2300, in the presence of a catalyst comprising a metal selected from (i) Re, (ii) a mixture comprising Re and at least one element selected from Pd, Ru, Mn, Cu, and Rh, (iii) a mixture comprising Ir and at least one element selected from Pd and Rh, (iv) Mn, (v) a mixture comprising Mn and Rh, (vi) Ag, (vii) Mg, and (viii) Rh at from 300 to 800° C. to form a trihalosilane.Type: GrantFiled: May 13, 2015Date of Patent: January 2, 2018Assignee: Dow Corning CorporationInventors: Stephanie Berger, Dimitris Katsoulis, Robert Thomas Larsen, Matthew J. McLaughlin, Unnikrishnan R. Pillai, Jonathan David Wineland