Patents by Inventor Thomas Lavstsen

Thomas Lavstsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides and polypeptides involved in gestational malaria, and biological applications
    Patent number: 8563008
    Abstract: The disclosure provides novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including the sequences for the preparation of immunogenic compositions and vaccines, antibodies, and to their for treating gestational malaria. Diagnostic methods and kits are described.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: October 22, 2013
    Assignees: Institut de Recherche pour le Development (IRD), Institut Pasteur
    Inventors: Philippe Lucien Deloron, Nicaise George Tuikue Ndam, Gwladys Irénée Bertin, Peter David, Emmanuel Bischoff, Caroline Stéphanie Proux, Jean-Yves Coppee, Ali Salanti, Thomas Lavstsen
  • POLYNUCLEOTIDES AND POLYPEPTIDES INVOLVED IN GESTATIONAL MALARIA, AND BIOLOGICAL APPLICATIONS
    Publication number: 20100255018
    Abstract: The present invention relates to novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including said sequences for the preparation of immunogenic compositions and vaccines, antibodies, and to the use thereof for treating gestational malaria. The invention also relates to diagnostic methods and kits.
    Type: Application
    Filed: April 17, 2008
    Publication date: October 7, 2010
    Applicants: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT PASTEUR
    Inventors: Philippe Lucien Deloron, Nicaise Georges Tuikue Ndam, Gwladys Irénée Bertin, Peter David, Emmanuel Bischoff, Caroline Stéphanie Proux, Jean-Yves Coppee Proux, Ali Salanti, Thomas Lavstsen
  • Compounds useful in the diagnosis and treatment of pregnancy-associated malaria
    Patent number: 7745580
    Abstract: The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides var2csa nucleic acid molecules as medicaments, as well as it provides pharmaceutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentioned for the manufacture of compositions, such as immunogenic compositions.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 29, 2010
    Assignee: Kobenhavns Universitet
    Inventors: Thor Grundtvig Theander, Ali Salanti, Lars Hviid, Trine Staalsø, Anja Tatiana Ramstedt Jensen, Thomas Lavstsen, Madelaine Dahlbäck
  • COMPOUNDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF MALARIA
    Publication number: 20090324628
    Abstract: The present invention relates to nucleic acid molecules related to the PFD1235w/MAL7P1.1, PF11_0008, and PF13_0003 gene families as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to endothelial cells, which is characteristic for the pathogenesis of severe malaria (SM). Accordingly, the invention provides pharmaceutical compositions and vaccines, hereunder nucleotide-based vaccines comprising compounds that are related to VAR4, VAR5, and/or VAR6 polypeptides and PFD1235w/MAL7P1.1 PF11_0008, and/or PF13_0003 nucleic acid molecules. The invention further relates to the use of these compounds as medicaments and for the manufacture of compositions, such as immunogenic compositions. In addition, the invention relates to methods of treatment and prevention of severe malaria wherein these methods are based on the nucleic acid molecules and polypeptides of the invention.
    Type: Application
    Filed: December 28, 2004
    Publication date: December 31, 2009
    Applicant: KOBENHAVNS UNIVERSITET PANIUM
    Inventors: Thor Grundtvig Theander, Thomas Lavstsen, Lars Hviid, Morten A. Nielsen, Pamela A. Magistrado, Ali Salanti, Trine Staalso, Anja Tatiana Ramstedt Jensen, Louise Jorgensen
  • Compounds useful in the diagnosis and treatment of pregnancy-associated malaria
    Publication number: 20070053928
    Abstract: The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides var2csa nucleic acid molecules as medicaments, as well as it provides pharmaccutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentioned for the manufacture of compositions, such as immunogenic compositions.
    Type: Application
    Filed: December 30, 2003
    Publication date: March 8, 2007
    Inventors: Thor Grundtvig Theander, Ali Salanti, Lars Hviid, Trine Staalso, Anja Jensen, Thomas Lavstsen, Madelaine Dahlback