Abstract: This disclosure describes a system and method for generating a subsurface model representing lithological characteristics and attributes of the subsurface of a celestial body or planet. By automatically ingesting data from many sources, a machine learning system can infer information about the characteristics of regions of the subsurface and build a model representing the subsurface rock properties. In some cases, this can provide information about a region using inferred data, where no direct measurements have been taken. Remote sensing data, such as aerial or satellite imagery, gravimetric data, magnetic field data, electromagnetic data, and other information can be readily collected or is already available at scale.

Abstract: The present disclosure provides a generative modeling framework for generating highly realistic and privacy preserving synthetic records for heterogenous time-series data, such as electronic health record data, financial data, etc. The generative modeling framework is based on a two-stage model that includes sequential encoder-decoder networks and generative adversarial networks (GANs).

Abstract: This disclosure relates generally to a system for mitigating error in an amplifier. The system may include a loop filter; a driver; a digital-to-analog converter (DAC) configured to source and to sink current; an edge selector configured to determine a first delay between the driver receiving a signal to provide a driver output signal and the driver providing the driver output signal; a timing circuit configured to determine a second delay between the DAC receiving a signal to provide a DAC output current and the DAC providing the DAC output current; and at least one controller configured to control the DAC to source or to sink the DAC output current at a time corresponding to a beginning of the driver output signal, and control the DAC to stop sourcing or sinking the DAC output current at a time corresponding to an end of the driver output signal.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: A system for surgical planning and assessment of spinal deformity correction is provided that has a spinal imaging system and a control unit. The spinal imaging system is configured to collect at least one digitized position of one or more vertebral bodies of a subject. The control unit is configured to receive the at least one digitized position, and calculate, based on the at least one digitized position, an optimized posture for the subject. The control unit is configured to receive one or more simulated spinal correction inputs, and based on the inputs and optimized posture, predict an optimal simulated postoperative surgical correction.

Abstract: Provided herein are, among other things, methods for treating a patient suffering from a CD20+ cancer.

Abstract: Embodiments of the present invention provide a method and apparatus for coordinated multi-AP channel access in a wireless network. A wireless AP that obtains a transmission opportunity (TXOP) (a “coordinator AP”) can grant one or more STAs or APs under control of the coordinator AP the use of some of the bandwidth granted by the TXOP. The STAs or APs that are granted the use of the bandwidth are referred to as “coordinated APs.” Thereafter, a coordinator AP or a coordinated AP can create a new basic service set (BSS) of devices for coordinating data transmissions. For example, the coordinated AP may serve as a relay, where the coordinated AP services devices in a new BSS by sending and receiving data with a coordinator AP in a different BSS.

Abstract: Systems and methods for processing digital medical images to infer metadata from those images are disclosed. In some aspects, digital medical images may be processed to infer metadata by receiving a plurality of digital medical images, receiving a prompt, the prompt being a request for a specific type of metadata to be inferred from the plurality of digital medical images, determining, using a trained foundation model, at least one feature descriptor from the plurality of digital medical images based on the prompt, and providing for output the at least one feature descriptor for each of the plurality of digital medical images.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

Abstract: A group head (20) for an espresso machine (10), the group head (20) comprising: a group head bracket (36) for detachable engagement with a portafilter (30) holding a puck (22) of ground coffee in a filter basket (64) to dispense an espresso coffee; a conduit (34) for receiving a flow of water to the portafilter (30); and, a heater (32) mounted in the group head (20) to heat the flow of water to the portafilter (30).

Abstract: A portable hose stand system enables the user to project a stream of water from a water hose or hose nozzle in a fixed direction. A hose receiver is configured to receive and retain a hose and is coupled with pivot to allow adjustment of a desire water flow direction and a pivot retainer locks in a desired position. The hose receive is configured on an extended end of a hose extension that extends from a stand body. Retractable legs extend down from the stand body and pivot away from each other to provide a stable base. Water flow may be controlled through the use of a motion sensor valve. Lastly, a wall mount serves as a receiver for the portable hose stand system as a faucet and/or shower.

Abstract: D-psicose/erythritol compositions comprise, in combination, D-psicose and erythritol as sweeteners together with one or more other edible ingredients. Comestibles are provided, including beverage products and other food products, comprising the novel D-psicose/erythritol compositions. D-psicose and erythritol may each be present in a comestible in a concentration sufficient independently of the other to perceptibly sweeten the composition. An additional sweetener component and other ingredients may be included in the formulation.

Abstract: Systems and methods permit or cause content to be displayed by a plurality of gaming displays, such as gaming machine displays and/or external displays. Content may be synchronously displayed by multiple gaming displays, such as one or more EGM displays and one or more external gaming displays, where the content which is displayed by the different displays may be the same or be different, and may be provided by a content controller and/or may be provided or triggered by a gaming machine. The systems and methods permit or cause content to be synchronously displayed across multiple gaming displays, such as in time and/or space. In some examples, the content is configured as a content “package” which is associated with one or more displays.

Abstract: Disclosed herein are systems and methods for processing speech signals in mixed reality applications. A method may include receiving an audio signal; determining, via first processors, whether the audio signal comprises a voice onset event; in accordance with a determination that the audio signal comprises the voice onset event: waking a second one or more processors; determining, via the second processors, that the audio signal comprises a predetermined trigger signal; in accordance with a determination that the audio signal comprises the predetermined trigger signal: waking third processors; performing, via the third processors, automatic speech recognition based on the audio signal; and in accordance with a determination that the audio signal does not comprise the predetermined trigger signal: forgoing waking the third processors; and in accordance with a determination that the audio signal does not comprise the voice onset event: forgoing waking the second processors.

Abstract: The present disclosure provides therapeutic methods of treating a cancer patient with TGO2 and a second therapeutic agent, e.g., TGO2 and an immune checkpoint inhibitor, TGO2 and a COX-2 inhibitor, or TGO2 and an immune checkpoint inhibitor and a COX-2 inhibitor.

Abstract: An apparatus for providing signals to a device may include one or more radio frequency signal generators, and electrically-small transmission line, which coupled signals from the one or more RF signal generators to a fabrication chamber. The apparatus may additionally include a reactive circuit to transform impedance of the electrically-small transmission line from a region of relatively high impedance-sensitivity to region of relatively low impedance-sensitivity.

Abstract: A tool system for installing a parking pawl includes a tool that includes a base, a plate, and an actuator. The base includes a base surface configured to support a parking pawl in a predetermined position. The plate includes a protrusion that extends upward from a front portion of the plate. A rear portion of the plate is coupled to a front portion of the base. The plate is movable relative to the base between a retention position in which the protrusion is positioned to retain a pawl spring loaded on the parking pawl in a pretensioned state, and a release position in which the protrusion is configured to release the pawl spring. The actuator is operably coupled to the plate such that activation of the actuator moves the plate between the retention position and the release position.

Abstract: A method for forming and installing a retaining ring comprises: feeding a wire in a linear path into a forming die having a circular bore; forming, using the forming die, the wire into a formed ring having a ring shape; transferring the formed ring from the forming die to a transfer puck; and installing the formed ring, as a retaining ring, in a tube of a product assembly. The formed ring is maintained in a constrained state between forming in the forming die and installation in the product assembly. A system for forming and installing a retaining ring into a product assembly includes a forming die configured to form a wire into a formed ring having a ring shape; and a transfer puck to transfer the formed ring from the forming die. The formed ring is maintained in a constrained state from forming through installation.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: Systems and methods for determining elevation based on structural modeling and light detection and ranging (LIDAR) data are disclosure. LIDAR bare earth data corresponding to an area within a parcel boundary is obtained as preliminary elevation data. A basis of structure boundary is determined for a structure within the parcel boundary based on an absence of the LIDAR bare earth data within a region in the area. Three-dimensional models are generated based on photographic data, to represent portions of the structure that affect LIDAR signals. A structure boundary for the structure is determined based on the basis of structure boundary in combination with supplemental elevation data generated using the three-dimensional models. Adjacent grade values are determined based on a portion of the preliminary elevation data and supplemental elevation data corresponding to an area between the structure boundary and a buffer boundary.