Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: A carrier for carrying an ophthalmic lens during its treatment in a bath comprises: a basket (10) comprising a basket wall defining a concave cavity (50) for accommodating an ophthalmic lens, the basket (10) further comprising a plurality of recesses (17) arranged in the basket wall at different angular locations along the circumference of the basket (10), each recess (17) being arranged to extend downwardly from an upper rim (15) of the basket wall; and a retainer (20) comprising a plurality of retainer arms (21), the retainer arms (21) being arranged in a star-shaped configuration at angular locations corresponding to the angular locations of the recesses (17), to in an assembled state of two such carriers (1) extends into a corresponding one of the plurality of recesses (17) in the basket wall to retain the ophthalmic lens in the carrier.

Abstract: A carrier for carrying an ophthalmic lens comprises: a basket (10) comprising a basket wall defining a concave cavity for accommodating an ophthalmic lens (100), the basket further comprising at least three recesses (12) arranged in the basket wall at different locations along the circumference of the basket (10); and a retainer (20) comprising at least three retainer arms (21) arranged in a star-shaped configuration corresponding to the arrangement of the recesses (12) along the circumference of the basket (10). In an assembled state each retainer arm (21) of the retainer (20) engages with a corresponding one of the recesses (12) in the basket wall of the basket (10) to retain the ophthalmic lens (100) in the cavity.

Abstract: The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

Abstract: A carrier for carrying an ophthalmic lens comprises: a basket (10) comprising a basket wall defining a concave cavity for accommodating an ophthalmic lens (100), the basket further comprising at least three recesses (12) arranged in the basket wall at different locations along the circumference of the basket (10); and a retainer (20) comprising at least three retainer arms (21) arranged in a star-shaped configuration corresponding to the arrangement of the recesses (12) along the circumference of the basket (10). In an assembled state each retainer arm (21) of the retainer (20) engages with a corresponding one of the recesses (12) in the basket wall of the basket (10) to retain the ophthalmic lens (100) in the cavity.

Abstract: The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

Abstract: The invention relates to a compound of the following general formula (tubulysin) having the following meanings for R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, S, T, U, V, W, X, Y and Z: R=H, alkyl, aryl, OR1, NR1R2 or R1=H, C1-6alkyl or aryl R2=H, C1-6alkyl or aryl S=H, Hal, NO2 or NHR3 U=H, Hal, NO2 or NHR3 R3=H, HCO or C1-4alkyl-CO T=H or OR4 R4=H, C1-4alkyl, aryl, COR5, P(O)(OR6)2 or SO3R6 R5=C1-6alkyl, alkenyl, aryl or heteroaryl R6=H, alkyl or a metal ion V=H, OR7, Hal or (for W=O) O R7=H, C1-4alkyl or COR8 R5=C1-4alkyl, alkenyl or aryl W=H or C1-4alkyl or (for V=O) O X=H, C1-4alkyl, alkenyl or CH2OR9 R9=H, C1-4alkyl, alkenyl, aryl or COR10 R10=C1-6alkyl, alkenyl, aryl or heteroaryl Y=(for Z=CH3 or COR11) free electron pair or (for Z=CH3)O R11=C1-4alkyl, CF3 or aryl and/or Z=(for Y=O or free electron pair) CH3 or (for Y=free electron pair) COR11.

Abstract: The invention relates to a compound of the following general formula (tubulysin) having the following meanings for R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, S, T, U, V, W, X, Y and Z: R=H, C1-4alkyl, aryl, OR1, NR1R2 or NH—(CH2)2-4 R1=H, C1-6alkyl or aryl R2=H, C1-6alkyl or aryl S=H, Hal, NO2 or NHR3 U=H, Hal, NO2 or NHR3 R3=H, HCO or C1-4alkyl-CO T=H or OR4 R4=H, C1-4alkyl, aryl, COR5, P(O)(OR6)2 or SO3R6 R5=C1-6alkyl, alkenyl, aryl or heteroaryl R6=H, alkyl or a metal ion V=H, OR7, Hal or (for W=O)O R7=H, C1-4alkyl or COR8 R5=C1-4alkyl, alkenyl or aryl W=H or C1-4alkyl or (for V=O) O X=H, C1-4alkyl, alkenyl or CH2OR9 R9=H, C1-4alkyl, alkenyl, aryl or COR10 R10=C1-6alkyl, alkenyl, aryl or heteroaryl Y=(for Z=CH3 or COR11) free electron pair or (for Z=CH3)O R11=C1-4alkyl, CF3 or aryl and/or Z=(for Y=O or free electron pair) CH3 or (for Y=free electron pair) COR11.

Abstract: The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents.

Abstract: The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents.

Abstract: The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure, which have microtubule-stabilizing effects and cytotoxic activity against rapidly proliferating cells, such as, tumor cells or other hyperproliferative cellular disease.

Abstract: The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor.

Abstract: The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure, which have microtubule-stabilizing effects and cytotoxic activity against rapidly proliferating cells, such as, tumor cells or other hyperproliferative cellular disease.

Abstract: The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.