Abstract: A device for carrying out cutting operations on at least one open format edge of a printed product, includes: a transport unit configured to transfer the printed product along a guide path from a first cutting location to a second cutting location and from the second cutting location to a third cutting location for an edge-related cutting operation, the transport unit having at least one gripper configured to grip the printed product by its spine to convey the printed product from one cutting location to the next in a suspended manner, and at at least one cutting location, at least one cutting tool configured to perform the edge-related cutting operation comprising a first edge-related cutting operation and optionally at least one second subsequent edge-related cutting operation.

Abstract: A device for carrying out cutting operations on at least one open format edge of a printed product, includes: a transport unit configured to transfer the printed product along a guide path from a first cutting location to a second cutting location and from the second cutting location to a third cutting location for an edge-related cutting operation, the transport unit having at least one gripper configured to grip the printed product by its spine to convey the printed product from one cutting location to the next in a suspended manner, and at at least one cutting location, at least one cutting tool configured to perform the edge-related cutting operation comprising a first edge-related cutting operation and optionally at least one second subsequent edge-related cutting operation.

Abstract: The invention provides methods of screening a microbial host cell for a property of interest in a microfluidic device, the method comprising the steps of: a) transforming a d-alanine racemase-deficient microbial host cell with a polynucleotide construct comprising: i) one or more polynucleotide region providing the property of interest when present in the host cell, and ii) at least one polynucleotide region complementing the d-alanine racemase deficiency when present in the host cell; and b) screening the transformed host cell for the property of interest in the microfluidic device in the absence of externally provided d-alanine.

Abstract: The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.

Abstract: The invention provides methods of screening a microbial host cell for a property of interest in a microfluidic device, the method comprising the steps of: a) transforming a d-alanine racemase-deficient microbial host cell with a polynucleotide construct comprising: i) one or more polynucleotide region providing the property of interest when present in the host cell, and ii) at least one polynucleotide region complementing the d-alanine racemase deficiency when present in the host cell; and b) screening the transformed host cell for the property of interest in the microfluidic device in the absence of externally provided d-alanine.

Abstract: The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.