Patents by Inventor Thomas Lepitre

Thomas Lepitre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C10-alkylene substituted 13-membered macrolides and uses thereof
    Patent number: 12552825
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: February 17, 2026
    Assignees: Zikani Therapeutics , Inc., President and Fellows of Harvard College
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Philip Hogan, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Andre Sanchez, Ganapathy Dhandapani, Thrimurtulu Neetipalli, Md. Ataur Rahman, Thomas Lepitre
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20260035335
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: August 11, 2025
    Publication date: February 5, 2026
    Inventors: Yue Pan, Alessandro Boezio, Cary Griffin Fridrich, Elaine B. Krueger, Demetri T. Moustakas, Kevin David Raynor, Kelley C. Shortsleeves, Thomas H. McLean, Michael Paul DeNinno, Christopher Thomson, Alexandre Larivee, Andrew J. Burnie, Bren-Jordan Atienza, Christian Perreault, Gaetan Maertens, Tarek Mohamed, Thomas Lepitre, Erich W. Baum, Hakan Gunaydin
  • C10-ALKYLENE SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF
    Publication number: 20260035402
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: October 9, 2025
    Publication date: February 5, 2026
    Inventors: Roger B. CLARK, Richard ALM, Wesley Francis AUSTIN, Philip HOGAN, Ivan JEWETT, Sushmita D. LAHIRI, Jonathan F. LAWRENCE, Xiben LI, Shuhao SHI, Wenying WANG, Yoshitaka ICHIKAWA, Andrew G. MYERS, Ziyang ZHANG, Peter Niels CARLSEN, Andre SANCHEZ, Ganapathy DHANDAPANI, Thrimurtulu NEETIPALLI, Md. Ataur RAHMAN, Thomas LEPITRE
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250313524
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: May 10, 2023
    Publication date: October 9, 2025
    Inventors: Yue Pan, Alessandro Boezio, Cary Griffin Fridrich, Elaine B. Krueger, Demetri T. Moustakas, Kevin David Raynor, Kelley C. Shortsleeves, Thomas H. McLean, Michael Paul DeNinno, Christopher Thomson, Alexandre Larivee, Andrew J. Burnie, Bren-Jordan Atienza, Christian Perreault, Gaetan Maertens, Tarek Mohamed, Thomas Lepitre, Erich W. Baum, Hakan Gunaydin
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250019380
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: July 13, 2022
    Publication date: January 16, 2025
    Inventors: Alessandro BOEZIO, Alexander M. TAYLOR, Cary Griffin FRIDRICH, Hakan GUNAYDIN, Lucian V. DIPIETRO, Levi Charles Thomas PIERCE, Mary M. MADER, Ravi KURUKULASURIYA, Thomas H. MCLEAN, Yue PAN, Michael Paul DENINNO, Alexandre LARIVEE, Andrew j. BURNIE, Caleb MEDENA, Gaetan MAERTENS, Kashif TANVEER, Mohan PAL, Tarek MOHAMED, Thomas LEPITRE, Bren-Jordan ATIENZA, Naresh VEMULA, Shorena GELOZIA
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20240287058
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 29, 2024
    Inventors: Alessandro BOEZIO, Lucian V. DIPIETRO, Cary Griffin FRIDRICH, Hakan GUNAYDIN, Ravi KURUKULASURIYA, André LESCARBEAU, Mary M. MADER, Thomas H. MCLEAN, Levi CharlesThomas PIERCE, Kevin David RAYNOR, Kelley C. SHORTSLEEVES, Yong TANG, Alexander M. TAYLOR, W. Patrick WALTERS, Hanmo ZHANG, Fabrizio GIORDANETTO, Yakov PECHERSKY, Qi WANG, Bren-Jordan ATIENZA, Megan BERTRAND-LAPERLE, Andrew J. BURNIE, Fei CHEN, Sampada CHITALE, Shorena GELOZIA, Jean-Benoit GIGUERE, Elodie LANDAGARAY, Alexandre LARIVEE, Thomas LEPITRE, Gaetan MAERTENS, Johanne OUTIN, Mohan PAL, Claudio STURINO, Kashif TANVEER, Rakesh THORAT, Naresh VEMULA, Elaine B. KRUEGER, Yue PAN, Michael Paul DENINNO, Yves BOUSQUET, Antoine JOBIN-DES LAURIERS, Jessica LEE, Tarek MOHAMED
  • C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof
    Publication number: 20230093692
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 23, 2023
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Hogan Philip, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Andre Sanchez, Ganapathy Dhandapani, Thrimurtulu Neetipalli, Md. Ataur Rahman, Thomas Lepitre