Abstract: Reverse-turn mimetics and methods relating to the same having the following structure are disclosed: including pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3 and R4 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are neurokinin (tachykinin) antagonists. Libraries containing the reverse-turn mimetics of this invention are also disclosed.

Abstract: The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

Abstract: Reverse-turn mimetics and methods relating to the same having the following structure are disclosed: including pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3 and R4 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are neurokinin (tachykinin) antagonists. Libraries containing the reverse-turn mimetics of this invention are also disclosed.

Abstract: The invention is directed toward a subsurface gravity measurement device and a method for calibrating the same that includes a tilt meter and a gravity sensor. The method includes associating tilt information produced by the gravity sensor as a function of a relationship between tilt information produced by the tilt meter and a correction parameter. The tilt meter produces tilt data, and the gravity meter produces gravity data, corresponding to the tilt data. The tilt data and gravity data is fitted to a polynomial equation that has a plurality of initial coefficients associated therewith. The initial coefficients includes information concerning the correction parameter. The correction parameter is derived as a function of the initial coefficients.

Abstract: The invention is directed toward a subsurface gravity measurement device and a method for calibrating the same that includes a tilt meter and a gravity sensor. The method includes associating tilt information produced by the gravity sensor as a function of a relationship between tilt information produced by the tilt meter and a correction parameter. The tilt meter produces tilt data, and the gravity meter produces gravity data, corresponding to the tilt data The tilt data and gravity data is fitted to a polynomial equation that has a plurality of initial coefficients associated therewith. The initial coefficients include information concerning the correction parameter. The correction parameter is derived as a function of the initial coefficients.

Abstract: A logic controller formed by self-contained device modules plugged onto a DIN rail and onto a backplane contained in the DIN rail, the modules variously comprising a power supply, a logic control, I/O devices and gateways, each I/O device having microprocessor power, and the modules having a sliding lock movable into position adjacent DIN-rail-engaging flexible tabs to block deflection of the tabs and removal of the module from the DIN rail.

Abstract: A system and method for preventing contact weld under various fault current conditions is disclosed. The system includes a contactor having stationary and movable contacts biased towards each other and switchable between an open and closed position. Energization of an electromagnetic coil engages the contacts creating an electric path for current flow through the contactor. Pulse width modulation is used to lower the power to the coil and maintain the contacts in the closed position. The contactor is equipped with safeguards to prevent contact welding. Under low fault currents, welding is prevented by contact material composition. Under intermediate fault currents, the contacts are blown open and remain open using magnetic components until the arc dissipates and the contacts have cooled sufficiently. Under high fault currents, the arrangement causes the contacts to blow open and separate the armature from the coil preventing re-engagement of the contacts until the coil is energized again.

Abstract: Molded case electric power switches such as circuit breakers, disconnects and transfer switches have an energy storage spring which rotates a cam assembly to close and initiate opening of the switch contacts. The cam assembly includes a drive cam with a cam lobe which engages a drive cam follower on the moving contact assembly. Due to space limitations, the cam assembly is positioned so that the drive cam follower initially moves toward the cam assembly during closing. To accommodate for this, the cam lobe has a generally radial leading edge to prevent binding of the drive cam follower. A single latch mechanism latches the cam assembly in a spring charged position and in a closed position. A Y-shaped latch member has one leg which is engaged by a latch, a second leg which engages stops on the drive cam at the charged position and the closed position, and a third leg which sequentially engages the stops to reset the latch mechanism.

Abstract: An image management system for use in conjunction with an ultrasound machine. The system comprises an input port coupled to the ultrasound machine for receiving the video output signal generated for the ultrasound images and a frame buffer for digitizing and storing the video output from the ultrasound. The system includes a switch for routing the video output signal or the video signal generated from the digitized ultrasound images to the monitor of the ultrasound for display. The system allows the original video signal to be displayed without introducing artifacts. The system includes storage-devices for archive and retrieval of the digitized ultrasound images and playback on the ultrasound monitor, The system also includes a communication port for interfacing the ultrasound with a PACS or a networked ultrasound management system.

Abstract: A motor control circuit for a power tool includes a function switch which has a first battery contact, a speed control contact, a bypass contact and, a second battery contact connected in that order in a line. The function switch also has a movable contact which sequentially connects the first battery contact to the bypass contact, the speed control contact to the second battery contact, and the bypass contact to the second battery contact. A solid state switch has conduction path connecting the speed control contact to the second motor terminal wherein the conduction path is controlled in response to an oscillator signal.