Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which an open port of a sampling probe for receiving a specimen may be exposed to washing solvent to wash the sampling probe while fluid within the sampling probe remains continuously flowing.

Abstract: Wireless communications systems and methods related to an efficient arithmetic coding based multiple composition distribution matcher (MCDM) are provided. A wireless communication device selects, based on a first value representing a sequence of bits, a first composition from a plurality of compositions. Each composition of the plurality of compositions includes a different modulation symbol distribution associated with a modulation scheme. The wireless communication device encodes, based on the first composition, the sequence of bits into a sequence of symbols using arithmetic coding. The wireless communication device transmits a communication signal including the sequence of symbols.

Abstract: Various schemes pertaining to center 996-tone resource unit (RU996) tone plan designs for wide bandwidth 240 MHz in wireless communications are described. A communication entity generates at least one 996-tone resource unit (RU996). The communication entity then communicates wirelessly using the at least one RU996 in a 240 MHz bandwidth. The at least one RU996 includes a center RU996 that is centered around five or more direct-current (DC) tones.

Abstract: Techniques are described for detecting a specified substance in an examination object by way of a magnetic resonance apparatus. A controller ascertains a magnetic resonance sequence comprising at least one sub-sequence for detecting at least one substance to be detected in the examination object as a function of the at least one substance to be detected, and ascertains at least one measuring instant for capturing a respective MRT signal to detect the at least one substance to be detected in the examination object as a function of the at least one substance to be detected. The at least one MRT signal is evaluated for fulfillment of a predetermined detection condition, and a presence of the at least one substance to be detected is established when the at least one MRT signal fulfils the predetermined detection condition.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: Techniques pertaining to efficient and flexible frequency domain (FD) aggregated physical-layer protocol data unit (FD-A-PPDU) with the same and/or mixed WiFi generations transmission are described. An apparatus (e.g., a station (STA)) performs a wireless communication by: (i) transmitting a FD-A-PPDU or (ii) receiving the FD-A-PPDU. The wireless communication is performed in a 160 MHz, 240 MHz, 320 MHz, 480 MHz or 640 MHz bandwidth with 80 MHz being a minimum size of each of multiple PPDUs of the FD-A-PPDU. The FD-A-PPDU may be a 160 MHz, 240 MHz, 320 MHz, 480 MHz or 640 MHz FD-A-PPDU. The FD-A-PPDU may include PPDUs having a same PPDU format or different PPDU formats of different WiFi generations and utilizing a minimum size of 80 MHz non-overlapping frequency subblocks as a base building block.

Abstract: The present disclosure relates to a device for measuring a first analyte concentration and a second analyte concentration in a measuring medium, the device including: a sample cell; a first light source unit; a first detector unit; a functional element; a second light source unit; a second detector unit; and a control unit adapted to analyze a detected first light for determining a first value representing the concentration of the first analyte in the measuring medium and adapted to analyze a detected third light for determining a second value representing the concentration of the second analyte in the measuring medium. A method of using the device is also disclosed.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Techniques pertaining to 80 MHz distributed-tone resource unit (dRU) tone plan-based dRU designs for wide distribution bandwidths 160 MHz and 320 MHz in wireless communications are described. An apparatus (e.g., station (STA)) generates a distributed-tone resource unit (dRU) using a 80 MHz dRU tone plan as a basic building block. The apparatus then performs a wireless communication in a 160 MHz or 320 MHz distribution bandwidth with the dRU.

Abstract: The present invention relates to methods and compositions for identifying, selecting and/or producing a pathogen resistant plant or germplasm (e.g., soybean plant or germplasm) using genes derived from Glycine tomentella. Candidate genes capable of conferring pathogen resistance (e.g., to Asian Soy Rust) are provided. A plant or germplasm that has been identified, selected and/or produced by any of the methods of the present invention is also provided. Pathogen resistant seeds, plants and germplasms are also provided.

Abstract: A method of adjusting a position of an electrode within a nebulizer probe of a mass spectrometry device having an open port interface for receiving a sample includes performing a first analysis of the sample at a first analysis condition including a first position of the electrode and a first flow rate. After performing the first analysis, a second analysis of the sample is performed at a second analysis condition including the first position of the electrode and a second flow rate higher than the first flow rate. Thereafter, a third analysis of the sample is performed at a third analysis condition including a second position of the electrode and the second flow rate.

Abstract: An integrated circuit includes first and second trenches in a semiconductor substrate and a semiconductor mesa between the first and second trenches. A source region having a first conductivity type and a body region having an opposite second conductivity type are located within the semiconductor mesa. A trench shield is located within the first trench, and a gate electrode is over the trench shield between first and second sidewalls of the first trench. A gate dielectric is on a sidewall of the first trench between the gate electrode and the body region, and a pre-metal dielectric (PMD) layer is over the gate electrode. A gate contact through the PMD layer touches the gate electrode between the first and second sidewalls, and a trench shield contact through the PMD layer touches the trench shield between the first and second sidewalls.

Abstract: An oral pharmaceutical composition is provided that can comprise a rho kinase inhibitor, for example, fasudil, a pharmaceutically acceptable salt thereof, a hydrate thereof, a prodrug thereof, a substituted derivative thereof, or a metabolite thereof, or any combination thereof, the rho kinase inhibitor having a bitter taste; and an ion exchange resin. The ion exchange resin can partially or fully mask the bitter taste of the rho kinase inhibitor, making the composition more palatable. The composition can comprise a solid dosage form, and/or a liquid dosage form. The solid dosage form can comprise a powder, granules, a tablet, or a capsule, or any combination thereof. The composition can be present, for example, in a unit dose, in an amount sufficient to treat a neurodegenerative disease. A method of treating the neurodegenerative disease with the oral pharmaceutical composition is provided. The method can ameliorate a symptom of a neurodegenerative disease.

Abstract: Disclosed herein are methods, compositions, and kits for engineering proteins using error-prone orthogonal replication (epOrthoRep) and yeast surface display (YSD).

Abstract: Methods for determining the presence of an unmeasured chemical in an environment can include receiving a plurality of sensor readings from a plurality of chemical sensors, wherein each chemical sensor of the plurality of chemical sensors is configured to detect a different chemical, determining a cross-sensitivity pattern from one or more unmeasured chemicals in the plurality of sensor readings, comparing the cross-sensitivity pattern with one or more known chemical patterns, determining that the cross-sensitivity pattern matches at least one of the one or more known chemical patterns that correspond to one or more chemicals, and identifying one or more unmeasured chemicals based on determining that the cross-sensitivity pattern matches the at least one of the one or more known chemical patterns.

Abstract: A resin including up to 99.99 weight percent (wt. %) of a first polyolefin grafted with a functional group selected from an ethylenically unsaturated carboxylic acid, a carboxylic acid anhydride, an ester functional group or a combination thereof; and 0.01 to 3.0 wt. % of a tin oxide-based catalyst, where the resin includes 0.2 wt. % to 1.5 wt. % of the functional group from the first polyolefin, the wt. % based on a total weight of the resin. The first polyolefin can be selected from a polyethylene, a polypropylene, an ethylene/alpha-olefin copolymer, a propylene/alpha-olefin copolymer and combinations thereof. The tin oxide-based catalyst can be selected from dibutyltin oxide, dioctyltin oxide and combinations thereof. The resin can be used in a multilayer structure, where a Layer A comprises the resin and a Layer B comprises a polyester, where a first major surface of Layer A is in adhering contact with the second major surface of Layer B.

Abstract: Integrated circuit structures having uniform grid metal gate and trench contact cut, and methods of fabricating integrated circuit structures having uniform grid metal gate and trench contact cut, are described. For example, an integrated circuit structure includes a vertical stack of horizontal nanowires. A gate electrode is over the vertical stack of horizontal nanowires. A conductive trench contact is adjacent to the gate electrode. A dielectric sidewall spacer is between the gate electrode and the conductive trench contact. A first dielectric cut plug structure extends through the gate electrode, through the dielectric sidewall spacer, and through the conductive trench contact. A second dielectric cut plug structure extends through the gate electrode, through the dielectric sidewall spacer, and through the conductive trench contact, the second dielectric cut plug structure laterally spaced apart from and parallel with the first dielectric cut plug structure.

Abstract: Techniques pertaining to distributed-tone resource unit (RU) designs for wide distribution bandwidth 160 MHz in wireless communications are described. An apparatus (e.g., station (STA)) generates a distributed-tone resource unit (dRU) of 52 tones or more using a 26-tone dRU as a building block. The apparatus then performs a wireless communication in a 160 MHz distribution bandwidth with the dRU.

Abstract: Techniques pertaining to signaling and padding methods for probabilistic shaping quadrature amplitude modulation (QAM) transmission in wireless communications are described. An apparatus (e.g., station (STA)) generates a packet using a probabilistic shaping (PS) 4096 quadrature amplitude modulation (4096QAM) such that a length of the packet is extended. The apparatus then transmits the packet in a wireless communication.

Abstract: Various schemes pertaining to distributed-tone resource unit (dRU) operation for wide bandwidths next-generation wireless local area network (WLAN) systems are described. A communication entity generates at least one dRU or both the at least one dRU and at least one regular resource unit (rRU). The communication entity then communicates wirelessly using the at least one dRU or using the at least one dRU and the at least one rRU in a 160 MHz, 240 MHz, 320 MHz, 480 MHz or 640 MHz bandwidth.