Abstract: A method for ensuring a microbiological purity of a single-use device for carrying out a biotechnological process, the single-use device including at least one gamma-sterilizable component which is formed from materials suitable for a sterilization by gamma radiation, and at least one non-gamma-sterilizable subunit which contains a material unsuitable for a sterilization by gamma radiation. Both the component and the subunit each have an area that comes into contact with a process medium when the biotechnological process is carried out.

Abstract: A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.

Abstract: A filtration device, in particular a disposable filtration device, has a flow path in which a filter element and an integrated flow reducer are arranged one behind the other. The flow reducer is adapted to be brought to a first operating position, which permits a defined first volume flow rate, and at least to a second operating position, which permits a defined second volume flow rate which is smaller than the first volume flow rate.

Abstract: A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f)

Abstract: A single-use device for filtration of a large volume of medium including a plurality of single-use filter units, at least some of which, preferably all of which, are connected to each other by rigid pipes. The filter units include at least one prefilter and at least one main filter for virus filtration which is configured as a hollow fiber capsule.

Abstract: A single-use device for separating or purifying a large volume of a mixture of substances including membrane chromatography modules which are fixedly mounted in a predetermined grid and a line system for linking the membrane chromatography modules and for connecting the membrane chromatography modules to each other. A cover or bottom mechanism holding the membrane chromatography modules in position in a predetermined grid may be attached to the upper or lower side of the membrane chromatography modules. At least part of the line system is formed in the cover or the bottom mechanism, with connecting lines between the membrane chromatography modules. In a method of separating or purifying a large volume of a mixture of substances using such a single-use device having a plurality of automated valves and sensors connected to a control unit, the automated valves are controlled based on an evaluation of the parameters measured by the sensors.

Abstract: A filter module for sterile filtration and virus filtration of fluid media. The filter module includes a filter membrane with a porous edge structure arranged thereon and at least one anchoring element. The filter membrane with the porous edge structure is embedded in the anchoring element and serves as edge reinforcement to improve the connection of the filter membrane to the anchoring element. The texturing or surface roughness of the edge reinforcement provides an interlocking effect between the filter membrane and the anchoring element. The embedding of the filter membrane in the anchoring element provides a fluid-tight connection of the membrane to the anchoring element which prevents the occurrence of leaks in the end region of the filter module. A method for producing the filter module is also described.

Abstract: A protective device (5, 5?, 5?, 5??, 5??) is provided for a hose clip (4) that connects a hose end (2) to a hose connection (3). The protective device includes a protective body (8, 8?, 8?, 8??, 8??) made of a plastic. In the assembled state, the protective body (8, 8?, 8?, 8??, 8??) surrounds the circumference of the hose clip (4) and accommodates the hose clip (4) at least in its clamping region via a radially oriented molding (32), and covers the hose clip (4) over the width thereof extending in the longitudinal direction of the hose connection (3). The protective body (8, 8?, 8?, 8??, 8??) has ring segments (9, 10) that can be connected to one another at their free ends (12, 13), and the segments are connected moveably to one another at their ends (14, 17) facing away from the free ends (12, 13).

Abstract: A valve includes a longitudinally movable valve body that is arranged in the valve, wherein the valve housing has at least two guide grooves, with which auxiliary guide elements, arranged on the valve body, engage an exterior surface of the valve housing. The guide grooves of the valve housing are shaped such that they define a combined translatory and rotary movement path of the valve body with the aid of the auxiliary guide elements in order to open or close the valve.

Abstract: The present invention relates to a porous sheet product, to a filter element comprising the porous sheet product, to a method for producing the porous sheet product, to a method for producing the filter element, and to the use of the sheet product and of the filter element.

Abstract: A disposable filtration device includes a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder. At least the holder and the lines between the filter capsules preferably are formed of a sterilizable material, so that the filtration device can be sterilized in the pre-mounted, i.e. ready-to-connect condition, and can be packed and transported without a risk of damage.

Abstract: The present invention relates to a melt-joined filter element with improved testability after dry steaming or alternatively after sterilization by irradiation, to a method for producing the filter element according to the invention, and to the use of the filter element for filtering solutions.

Abstract: A filter module with a perforated inner tube (20) and a concentric, perforated outer tube (22), forming an interposed annular gap for a filter membrane (10) pleated into folds. The membrane folds (11, . . . ) are of different fold types with differing fold heights, extend from a respective fold edge (111, . . . ) resting against the outer tube towards the inner tube to the respective fold tip (114, . . . ) and are arranged along the circumference of the annular gap as groups of folds (11, . . . ) of different types. Each group has a mating fold (15) which extends from a mating fold edge (151) resting against the inner tube towards the outer tube to the mating fold tip (154). The height of the mating fold is no more than the difference between the width of the annular gap and the height of the fold type with the shortest height of the same group.

Abstract: A single-use device for filtration of a large volume of medium comprises a plurality of single-use filter units, at least some of which, preferably all of which, are connected to each other by rigid pipes. The filter units include at least one prefilter and at least one main filter for virus filtration which is configured as a hollow fiber capsule.

Abstract: A filter module having an edge-reinforced membrane, a method for producing the filter module, and the use thereof.

Abstract: The present invention relates to a micro-porous filtration membrane with performance enhancing projections as well as a method for producing the same.

Abstract: A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f)

Abstract: A filter module with a perforated inner tube (20) and a concentric, perforated outer tube (22), forming an interposed annular gap for a filter membrane (10) pleated into folds. The membrane folds (11, . . . ) are of different fold types with differing fold heights, extend from a respective fold edge (111, . . . ) resting against the outer tube towards the inner tube to the respective fold tip (114, . . . ) and are arranged along the circumference of the annular gap as groups of folds (11, . . . ) of different types. Each group has a mating fold (15) which extends from a mating fold edge (151) resting against the inner tube towards the outer tube to the mating fold tip (154. The height of the mating fold is no more than the difference between the width of the annular gap and the height of the fold type with the shortest height of the same group.

Abstract: A cover panel for a storage area of a motor vehicle, and a corresponding method, is disclosed. An example motor vehicle includes, among other things, a rear loading flap providing access to a storage area, and a cover panel connected to the rear loading flap such that, when the rear loading flap is in a closed position, the cover panel provides an upper boundary of the storage area and is supported solely by the rear loading flap.

Abstract: A device is provided for changing the volume of a loading space in a vehicle. The device includes a movable loading surface, a side wall and at least one pivotable support arranged on the side wall. The support has a support surface on which the loading surface is mounted in a raised position. The support is arranged on a pivot axis oriented perpendicularly to the loading surface.