Patents by Inventor Thomas Low

Thomas Low has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210179560
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Application
    Filed: August 3, 2020
    Publication date: June 17, 2021
    Inventors: Michael D. Bartberger, Ana Gonzalez Buenrostro, Hilary Plake Beck, Xiaoqi Chen, Richard Victor Connors, Jeffrey Deignan, Jason A. Duquette, I, John Eksterowicz, Benjamin Fisher, Brian M. Fox, Jiasheng Fu, Zice Fu, Felix Gonzalez Lopez De Turiso, Michael W. Gribble, Darin J. Gustin, Julie A. Heath, Xin Huang, XianYun Jiao, Michael G. Johnson, Frank Kayser, David John Kopecky, SuJen Lai, Yihong Li, Zhihong Li, Jiwen Liu, Jonathan D. Low, Brian S. Lucas, Zhihua MA, Lawrence R. McGee, Joel McIntosh, Dustin L. McMinn, Julio C. Medina, Jeffrey Thomas Mihalic, Steven H. Olson, Yossup Rew, Philip M. Roveto, Daqing Sun, Xiaodong Wang, Yingcai Wang, Xuelei Yan, Ming Yu, Jiang Zhu
  • Patent number: 10969004
    Abstract: A vehicle includes a main body, a transmission having a plurality of gear stages, a data storage, and an electronic controller. The data storage stores vehicle running condition data that includes at least one of a prescribed vehicle running condition, a sensed vehicle running condition, or a transmitted vehicle running condition. The electronic controller determines a gear shift of the gear stages of the transmission based on a future vehicle speed that has been estimated based on the vehicle running condition data.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 6, 2021
    Assignees: SRI INTERNATIONAL, YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Keiji Nishimura, Thomas Low
  • Patent number: 10906168
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: February 2, 2021
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 10899016
    Abstract: An example system includes a vehicle, a robot, and a controller. The vehicle may include an accelerator operator and a steering operator. The robot may include as accelerator actuator configured to operate the accelerator operator, and a steering actuator configured to operate-the steering operator. The controller is configured to: in response to an accelerator command, send a first signal to the accelerator actuator to operate the accelerator operator of the vehicle, and in response to a steering command, send a second, signal to the steering actuator to steer the vehicle.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 26, 2021
    Assignees: SRI INTERNATIONAL, YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Thomas Low, Thomas De Candia, Seungkook Yun, Thomas Egan, Bryan Chavez, Alexander Kernbaum, Riley Shear, Leonard Gerard, Stephen Morfey, Richard Mahoney, Regis Vincent, Paul Birkmeyer, Hiroyuki Morita, Hirokatsu Muramatsu, Keiji Nishimura, Hiroshi Saijou, Akira Satou, Toshifumi Uchiyama, Hitoshi Watanabe, Shirou Watanabe
  • Publication number: 20200218253
    Abstract: A hybrid control system includes a control agent and a control engine. The control engine is configured to install a master plan to the control agent. The master plan includes a plurality of high-level tasks. The control agent is configured to operate according to the master plan to, for each high-level task of the high-level tasks, obtain one or more low-level controls and to perform the one or more low-level controls to realize the high-level task. The control agent is configured to operate according to the master plan to transition between the plurality of high-level tasks thereby causing a seamless transition between operating at least partially autonomously and operating at least partially based on input from the tele-operator, based at least on context for the control agent, to operate at least partially autonomously and at least partially based on input from the tele-operator during execution of the master plan.
    Type: Application
    Filed: August 17, 2018
    Publication date: July 9, 2020
    Inventors: Bhaskar Ramamurthy, Supun Samarasekera, Thomas Low, Manish Kothari, John Peter Marcotullio, Jonathan Brookshire, Tobenna Arodiogbu, Usman Ghani
  • Publication number: 20190210591
    Abstract: Systems and methods are provided to enhance the driving performance of a leanable vehicle such as a motorcycle. The system includes a leanable vehicle interface to receive input from a driver (e.g., a human or a robotic driver) and a sensor interface to receive inputs from sensors on the leanable vehicle. The system also includes a computing module to use the sensor data in combination with data from the leanable vehicle interface to calculate the driver behavior to produce a future desired performance, based on a specified aggressiveness, so that the performance of the leanable vehicle is optimized. The calculation may be done using a machine learning method, a rule based method, or both.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Inventors: Thomas Low, Bruce Knoth, Brian Foster, Huihua Zhao, Martin Gaudreault
  • Publication number: 20190211919
    Abstract: A vehicle includes a main body, a transmission having a plurality of gear stages, a data storage, and an electronic controller. The data storage stores vehicle running condition data that includes at least one of a prescribed vehicle running condition, a sensed vehicle running condition, or a transmitted vehicle running condition. The electronic controller determines a gear shift of the gear stages of the transmission based on a future vehicle speed that has been estimated based on the vehicle running condition data.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Inventors: Keiji NISHIMURA, Thomas LOW
  • Publication number: 20180361566
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 20, 2018
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 10105839
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 23, 2018
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20180297209
    Abstract: An example system includes a vehicle, a robot, and a controller. The vehicle may include an accelerator operator and a steering operator. The robot may include as accelerator actuator configured to operate the accelerator operator, and a steering actuator configured to operate-the steering operator. The controller is configured to: in response to an accelerator command, send a first signal to the accelerator actuator to operate the accelerator operator of the vehicle, and in response to a steering command, send a second, signal to the steering actuator to steer the vehicle.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 18, 2018
    Inventors: Thomas LOW, Thomas DE CANDIA, Seungkook YUN, Thomas EGAN, Bryan CHAVEZ, Alexander KERNBAUM, Riley SHEAR, Leonard GERARD, Stephen MORFEY, Richard MAHONEY, Regis VINCENT, Paul BIRKMEYER, Hiroyuki MORITA, Hirokatsu MURAMATSU, Keiji NISHIMURA, Hiroshi SAIJOU, Akira SATOU, Toshifumi UCHIYAMA, Hitoshi WATANABE, Shirou WATANABE
  • Patent number: 9950422
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: April 24, 2018
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 9427864
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: August 30, 2016
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 9403272
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: August 2, 2016
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20160101516
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: September 25, 2015
    Publication date: April 14, 2016
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20160101517
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: September 25, 2015
    Publication date: April 14, 2016
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 9266233
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 23, 2016
    Assignee: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20150266180
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: March 30, 2015
    Publication date: September 24, 2015
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20150266181
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: March 30, 2015
    Publication date: September 24, 2015
    Inventors: Roy David Kornbluh, Alexander Steele Kernbaum, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Publication number: 20140277739
    Abstract: A flexible exosuit includes rigid and flexible elements configured to couple forces to a body of a wearer. Further, the flexible exosuit includes flexible linear actuators and clutched compliance elements to apply and/or modulate forces and/or compliances between segments of the body of the wearer. The flexible exosuit further includes electronic controllers, power sources and sensors. The flexible exosuit can be configured to apply forces to the body of the wearer to enable a variety of applications. In some examples, the flexible exosuit can be configured to augment the physical strength or endurance of the wearer. In some examples, the flexible exosuit can be configured to train the wearer to perform certain physical tasks. In some examples, the flexible exosuit can be configured to record physical activities of the wearer.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: SRI International
    Inventors: Roy David Kornbluh, Alexander Steele Kernbuam, Thomas Low, Katherine Goss Witherspoon, Brian Keith McCoy, Adam Arnold Edward Ziemba, Paul Michael Birkmeyer, Richard M. Mahoney
  • Patent number: 8488295
    Abstract: A selectively rigidizable and actively steerable device is described. In one aspect, an articulatable device is described that includes a flexible inner tube having a first lumen, a flexible outer tube that receives the inner tube, and a multiplicity of overlapping, rigidizable scale-like strips. Each scale-like strip is coupled with the inner tube and positioned between the inner and outer tubes. Of particular note, the overlapping strips are actuatable between a non-rigidized state in which overlapping strips are slideable relative to one another and a rigidized state in which overlapping strips are not slideable relative to one another.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: July 16, 2013
    Assignee: SRI International
    Inventors: Pablo Garcia, Thomas Low, Bryan Chavez, Harsha Prahlad