Abstract: The invention relates to a method for diagnosis of an autoimmune disease in a subject wherein, presence or absence of an anti-CXC chemokine receptor (CXCR) antibody is detected in a sample from the subject diagnosed, and wherein the presence of an anti-CXCR antibody is indicative of the disease. The invention further relates to the use of (auto)antibodies against the C—X—C chemokine receptor type 3 (CXCR3) as a prognostic marker in subjects with acute graft-versus-host disease (GVHD), particularly in subjects with high grade acute GVHD. The invention also relates to the use of C—X—C chemokines selected from the group consisting of CXCL4, CXCL9, CXCL10 and CXCL11, preferably CXCL9, as a prognostic marker in subjects with acute GVHD, particularly in subjects with high grade acute GVHD.

Abstract: The present invention relates to compositions for the treatment of a malignant disease and in particular to compositions comprising an NF-?B inhibitor and a ?-glutamyltransferase (?-GT) inhibitor and therapeutic uses thereof. The invention further relates to in vitro methods of testing putative anti-tumour agents for their potential to act as therapeutically effective anti-tumour agents in vivo. Embodiments of the invention have been particularly developed for bringing NF-?B inhibitors to the clinic such as to provide alternative therapeutic options in the treatment of malignant diseases and will be described hereinafter with reference to this application. However, it will be appreciated that the invention is not limited to this particular field of use.

Abstract: A device for the illumination of a display, in particular of a transmission display of a motor vehicle, comprises an areal lighting means for an at least substantially uniform illumination of the total display in combination with at least one light emitting diode for an illumination of a respective individual display, in particular of a transmission position display offset in comparison with the uniform illustration of the total display, in particular a more intensive illustration of a respective individual display, in particular of a transmission position display.

Abstract: The connection device (101, 201) according to the invention has a locking head (109, 209) that can be locked to an opening (8) of a container wall (3). A clamping device (123, 223) is also provided on the corresponding coupling piece (5), which serves to tighten the head (109, 209) locked to the container wall (3) without a rotational movement against the container wall (3). The clamping device (123, 223) can be designed as a wedge-clamping device (142, 242). The latter permits generation of large clamping forces with small operating forces. The clamping device (142, 242) is preferably secured by a locking device (253), so that vibration-proof connection resistant to temperature changes is achieved during simple assembly.

Abstract: A flexible corrugated hose fitting, which is particularly provided for high-pressure installations, such as air conditioning installations using CO2 as the refrigerant, has a connecting element, which can be snapped together with the interior corrugated pipe of the flexible corrugated hose. In addition, the connecting element has sealing elements, which come into sealing contact with the corrugated pipe. Following the area receiving the sealing elements, the connecting element has a cone, which is used as a clamping section. An exterior squeeze ring, or other squeeze element, is used for pressing the exposed end of the corrugated pipe against the clamping section. A pressing sleeve is used for pressing, which drives the squeeze ring by a wedge effect inward. It has an appropriate conical interior surface. The squeeze ring moreover extends over the sheathing. For further securing of the connection, the pressing sleeve can be pressed together here with the sheathing by an appropriate deformation.

Abstract: A device for the illumination of a display, in particular of a transmission display of a motor vehicle, comprises an areal lighting means for an at least substantially uniform illumination of the total display in combination with at least one light emitting diode for an illumination of a respective individual display, in particular of a transmission position display offset in comparison with the uniform illustration of the total display, in particular a more intensive illustration of a respective individual display, in particular of a transmission position display.

Abstract: The connection device (101, 201) according to the invention has a locking head (109, 209) that can be locked to an opening (8) of a container wall (3). A clamping device (123, 223) is also provided on the corresponding coupling piece (5), which serves to tighten the head (109, 209) locked to the container wall (3) without a rotational movement against the container wall (3). The clamping device (123, 223) can be designed as a wedge-clamping device (142, 242). The latter permits generation of large clamping forces with small operating forces. The clamping device (142, 242) is preferably secured by a locking device (253), so that vibration-proof connection resistant to temperature changes is achieved during simple assembly.

Abstract: A flexible corrugated hose fitting 1, which is particularly provided for high-pressure installations, such as airconditioning installations using CO2 as the refrigerant, has a connecting element 11, which can be snapped together with the interior corrugated pipe 5 of the flexible corrugated hose 3. In addition, the connecting element 11 has sealing elements 23, 24, which come into sealing contact with the corrugated pipe 5. Following the area receiving the sealing elements 23, 24, the connecting element 11 has a cone 26, which is used as a clamping section. An exterior squeeze ring 34, or other squeeze element, is used for pressing the exposed end of the corrugated pipe against the clamping section 26. A pressing sleeve 38 is used for pressing, which drives the squeeze ring 36 by a wedge effect inward. It has an appropriate conical interior surface 42. The squeeze ring 34 moreover extends over the sheathing 8.

Abstract: A plug-in line connector (1) for especially simple and secure assembly has a fluid-tight plug-in connection and a locking device (25), which is very easy to access when its retaining parts are assembled in the axial direction and which is locked so that it cannot be released by passing a locking point. A tension spring, which is formed as a ring and acts as a block, is used for the locking element. This guarantees particularly low activation forces and minimizes axial play.

Abstract: A quick-fitting pipe union is proposed with an insertion component, a socket component and at least one sealing element. The sealing element (7) excels by virtue of the feature that it comprises a connecting section (9) and two lips (11) that extend outward from the connecting section (9).

Abstract: A coupling arrangement connects two elements with each other. The coupling arrangement includes a plug element and a bushing element which are configured in such a manner that they can be plugged together and locked in position by means of an expandable retaining ring. An axially movable release arrangement cooperates with the retaining ring in order to release the locking mechanism. The coupling arrangement is characterized in that the release arrangement (41) comprises a release sleeve (43), which can be closed with a cover (51) on its side facing away from the bushing element (5), and that a blocking device (55) is used to prevent an inadvertent release of the coupling.

Abstract: A coupling assembly for connecting two tubular elements, in particular ends of two tubes of an air-conditioning system, includes two inter-engaging locking parts which, for the purpose of achieving a locked position, can be rotated with respect to one another and can be displaced with respect to one another in the axial direction. The locking parts utilize a bayonet locking feature and include at least two sub-elements, the sub-elements being fixed in the radial direction by two inter-engaging sleeves.

Abstract: A connecting device is provided particularly as a quick-connect device for connecting fluid channels on motor vehicles. The connecting device features two axial connecting elements that are to be clamped and that are sealed by a sealing element to be deformed in the axial direction. The deformation of the sealing element is limited by mechanical stop means (support surfaces). A wedge-clamping device is used for clamping the connecting elements against each other.

Abstract: This invention relates to a coupling device to connect two tubular elements, preferably a hose with a tube, with one male coupling element (3) and one female coupling element (5) that are formed so that they can be inserted in one another and can be locked by means of an expandable split clip (33). An axially movable release device (35) interacts with the split clip to release the lock. The invention is characterized by the fact that the release device (35) has an indicator element which indicates a connection between the two coupling elements (3, 5).