Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: A system for securing shoes to the feet using a single pull shoe closure arrangement. Each of the various embodiments utilizes a “transverse strap” arrangement that extends between the lateral and medial sides of the shoe across the tongue or top portion of the shoe. The transverse strap is a single, generally flat, strap extending from one side of the shoe across the top portion of the shoe to the opposite side where it joins with a single pull sub-system. The preferred embodiments use a single pull system oriented longitudinally along one side of the shoe to draws upon one end of the transverse strap configuration to affect the shoe closure. Alternate embodiments pull a shorter draw strap laterally to a point of securement on the side of the shoe below the tongue area without the need for a longitudinal pull motion.

Abstract: A system for securing shoes to the feet using a one or two pull shoe closure arrangement. Each embodiment of the system uses a squared-cord arrangement that extends between the lateral and medial sides of the shoe. The various embodiments arrange either one or two draw straps connected to one or more squared-cord portions to draw in and tighten the sides of the squared-cord arrangement. A single pull strap in a first embodiment is redirected from a lateral orientation to a longitudinal orientation where it is drawn back and secured on the heel portion of the shoe. Alternate embodiments pull two parallel shorter draw straps laterally to points of securement on the sides of the shoe. Further alternate embodiments pull a draw strap longitudinally along a midline at the top of the shoe to a point of securement back onto the squared-cord arrangement.

Abstract: A system of attachment surface structures that find their best use in the form of repeatedly removable straps and bands for securing one object to another. The surfaces are preferably constructed of narrow sheets of flexible polymer plastic materials having generally high tensile strength. A first embodiment includes shaped parallel ridges on one surface that interlock with mating parallel ridges on an opposing surface. These parallel ridges may be double sided (interlocking on both sides of each shaped ridge with the next shaped ridge on either side) or single sided (interlocking with a single ridge oriented 180 degrees from the first). Further embodiments include an array of shaped posts of various regular geometric shapes that interlock with an opposing array of similar or distinct posts.

Abstract: A system for securing shoes to the feet using a one pull shoe closure arrangement. Each embodiment of the system uses a squared-cord arrangement that extends between the lateral and medial sides of the shoe. The various embodiments arrange a single draw strap connected to one or more squared-cord portions to draw in and tighten the sides of the squared-cord arrangement. A single pull strap in a first embodiment is redirected from a lateral orientation to a longitudinal orientation where it is drawn back and secured on the heel portion of the shoe. Alternate embodiments pull a shorter draw strap laterally to a point of securement on the side of the shoe. Further alternate embodiments pull a draw strap longitudinally along a midline at the top of the shoe to a point of securement back onto the squared-cord arrangement.

Abstract: A system for securing shoes to the feet using a one pull shoe closure arrangement. Each embodiment of the system uses a squared-cord arrangement that extends between the lateral and medial sides of the shoe. The various embodiments arrange a single draw strap connected to one or more squared-cord portions to draw in and tighten the sides of the squared-cord arrangement. A single pull strap in a first embodiment is redirected from a lateral orientation to a longitudinal orientation where it is drawn back and secured on the heel portion of the shoe. Alternate embodiments pull a shorter draw strap laterally to a point of securement on the side of the shoe. Further alternate embodiments pull a draw strap longitudinally along a midline at the top of the shoe to a point of securement back onto the squared-cord arrangement.

Abstract: A system of attachment surface structures that find their best use in the form of repeatedly removable straps and bands for securing one object to another. The surfaces are preferably constructed of narrow sheets of flexible polymer plastic materials having generally high tensile strength. A first embodiment includes shaped parallel ridges on one surface that interlock with mating parallel ridges on an opposing surface. These parallel ridges may be double sided (interlocking on both sides of each shaped ridge with the next shaped ridge on either side) or single sided (interlocking with a single ridge oriented 180 degrees from the first). Further embodiments include an array of shaped posts of various regular geometric shapes that interlock with an opposing array of identical posts.

Abstract: A system for securing shoes to the feet utilizing a one or two pull fit adjustment set of straps. The embodiments utilize a number of straps, some variable in length, positioned at select points across and around the top and sides of the shoe. At least one strap in the system provides an adjustable length whereby all straps may be drawn together to tighten the shoe, preferably in both a horizontal and a vertical direction across the profile of the shoe. The system utilizes a variety of strong, lightweight, nylon buckles, strips, anchor loops, permitting attachment and motion of the adjustment straps over the top and sides of the shoe. Included are three-point attachment embodiments, as well as two-point attachment embodiments, most with a one pull adjustment structure. Most embodiments are on the medial side of the shoe although some may be implemented on the lateral side.

Abstract: Systems for securing shoes to the feet utilizing a one pull fit adjustment set of straps. The embodiments each utilize a number of straps, some fixed and some variable in length, positioned at select points across and around the top and sides of the shoe. At least one strap in the system provides an adjustable length whereby all straps may be drawn together to create a fit that tightens the shoe, preferably in both a horizontal and a vertical direction across the profile of the shoe. The systems use a variety of strong, but lightweight, nylon buckles, strips, anchor loops, and combinations thereof to permit the attachment and motion of the adjustment straps over the top and sides of the shoe. Three-point, as well as two-point attachment embodiments, most with a one pull adjustment are described. The systems are preferably on the medial side of the shoe.

Abstract: A system of attachment surface structures that find their best use in the form of repeatedly removable straps and bands for securing one object to another. The surfaces are preferably constructed of narrow sheets of flexible polymer plastic materials having generally high tensile strength. A first embodiment includes shaped parallel ridges on one surface that interlock with mating parallel ridges on an opposing surface. These parallel ridges may be double sided (interlocking on both sides of each shaped ridge with the next shaped ridge on either side) or single sided (interlocking with a single ridge oriented 180 degrees from the first). Further embodiments include an array of shaped posts of various regular geometric shapes that interlock with an opposing array of identical posts.

Abstract: Systems and methods discussed herein relate to a personalized recommendation engine. The personalized recommendation engine makes recommendations for packages of components sold and/or supported by a telecommunications service provider such as electronic devices, accessories, subscription plans, services, and applications. These package recommendations are based upon user input, telecommunications service provider input, and customer feedback from customers who made previous purchases using the personalized recommendation engine. Each component from a pool of components is ranked based upon this input, package components are selected and bundled, and the packages are recommended to the user based upon the overall package score which is determined by user input, telecommunications service provider input, and in some cases customer feedback.

Abstract: A structured mat that is placed on an automobile's dashboard (and/or the rear window shelf) and provided with a quantity of water, or other suitable liquid, that on heating will evaporate into the interior air of the vehicle. The mat structure includes a water impermeable layer that lays against and partially covers the top surface of the dashboard and/or rear shelf and a fluid wicking layer over the impermeable layer that may be saturated with evaporative fluid (on a repeated basis as necessary) and serve as a reservoir for the evaporative process to be carried out. The multilayered surface may be manually refilled with water (or other suitable liquid) from a hand held container or may be automatically refilled from reservoirs structured in fluid connection to the evaporative surface.

Abstract: A system of attachment surface structures that find their best use in the form of repeatedly removable straps and bands for securing one object to another. The surfaces are preferably constructed of narrow sheets of flexible polymer plastic materials having generally high tensile strength. A first embodiment includes shaped parallel ridges on one surface that interlock with mating parallel ridges on an opposing surface. These parallel ridges may be double sided (interlocking on both sides of each shaped ridge with the next shaped ridge on either side) or single sided (interlocking with a single ridge oriented 180 degrees from the first). Further embodiments include an array of shaped posts of various regular geometric shapes that interlock with an opposing array of identical posts. Further embodiments include parallel ridge pairs that interlock with parallel post-type ridges that lend themselves to extrusion manufacturing.

Abstract: A structured cover that is placed on an automobile's dashboard (and/or the rear window shelf) and provided with a quantity of water, or other suitable liquid, that on heating will evaporate into the interior air of the vehicle. The device includes a water impermeable layer that lays against and partially covers the top surface of the dashboard and/or rear shelf and a water wicking layer over the impermeable layer that may be saturated with water (on a repeated basis as necessary) and serve as a reservoir for the evaporative process to be carried out. The multilayered surface may be manually refilled with water (or other suitable liquid) from a hand held container or may be automatically refilled from reservoirs structured in fluid connection to the evaporative surface.

Abstract: A system for securing shoes to the feet utilizing a one or two pull fit adjustment set of straps. The embodiments utilize a number of straps, some variable in length, positioned at select points across and around the top and sides of the shoe. At least one strap in the system provides an adjustable length whereby all straps may be drawn together to tighten the shoe, preferably in both a horizontal and a vertical direction across the profile of the shoe. The system utilizes a variety of strong, lightweight, nylon buckles, strips, anchor loops, permitting attachment and motion of the adjustment straps over the top and sides of the shoe. Included are three-point attachment embodiments, as well as two-point attachment embodiments, most with a one pull adjustment structure. Most embodiments are on the medial side of the shoe although some may be implemented on the lateral side.

Abstract: A system of attachment surface structures that find their best use in the form of repeatedly removable straps and bands for securing one object to another. The surfaces are preferably constructed of narrow sheets of flexible polymer plastic materials having generally high tensile strength. A first embodiment includes shaped parallel ridges on one surface that interlock with mating parallel ridges on an opposing surface. These parallel ridges may be double sided (interlocking on both sides of each shaped ridge with the next shaped ridge on either side) or single sided (interlocking with a single ridge oriented 180 degrees from the first). Further embodiments include an array of shaped posts of various regular geometric shapes that interlock with an opposing array of identical posts. Further embodiments include parallel ridge pairs that interlock with parallel post-type ridges that lend themselves to extrusion manufacturing.

Abstract: A structured cover that is placed on an automobile's dashboard (and/or the rear window shelf) and provided with a quantity of water, or other suitable liquid, that on heating will evaporate into the interior air of the vehicle. The device includes a water impermeable layer that lays against and partially covers the top surface of the dashboard and/or rear shelf and a water wicking layer over the impermeable layer that may be saturated with water (on a repeated basis as necessary) and serve as a reservoir for the evaporative process to be carried out. The multilayered surface may be manually refilled with water (or other suitable liquid) from a hand held container or may be automatically refilled from reservoirs structured in fluid connection to the evaporative surface.

Abstract: Systems for securing shoes to the feet utilizing a one pull fit adjustment set of straps. The embodiments each utilize a number of straps, some fixed and some variable in length, positioned at select points across and around the top and sides of the shoe. At least one strap in the system provides an adjustable length whereby all straps may be drawn together to create a fit that tightens the shoe, preferably in both a horizontal and a vertical direction across the profile of the shoe. The systems use a variety of strong, but lightweight, nylon buckles, strips, anchor loops, and combinations thereof to permit the attachment and motion of the adjustment straps over the top and sides of the shoe. Three-point, as well as two-point attachment embodiments, most with a one pull adjustment are described. The systems are preferably on the medial side of the shoe.

Abstract: The present invention involves a golf tee coated with colored coatings that when struck with a golf club leave a marking that easily identifies where the ball was struck on the club face and the path of the swing, but does not come off in normal handling. The tee leaves a multi-colored marking on the club face that is used to show the swing path of a golfer's swing and the point of impact of the tee on the face of the golf club. The tee has a center line or mark that represents the middle, which establishes the optimum hitting area. This line or mark is also an indicator for the golfer to line up in the direction they are trying to hit the ball. On either side of this colored line or mark is a different color that indicates the swing path when shown on the club face.

Abstract: The present invention involves a golf tee coated with colored coatings that when struck with a golf club leave a marking that easily identifies where the ball was struck on the club face and the path of the swing, but does not come off in normal handling. The tee leaves a multi-colored marking on the club face that is used to show the swing path of a golfer's swing and the point of impact of the tee on the face of the golf club. The tee has a center line or mark that represents the middle, which establishes the optimum hitting area. This line or mark is also an indicator for the golfer to line up in the direction they are trying to hit the ball. On either side of this colored line or mark is a different color that indicates the swing path when shown on the club face.