Patents by Inventor Thomas M. Bare

Thomas M. Bare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridazinedione compounds useful in treating neurological disorders
    Patent number: 5604227
    Abstract: The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: February 18, 1997
    Assignee: Imperial Chemical Industries PLC
    Inventors: Thomas M. Bare, Richard B. Sparks
  • Pyridazinedione compounds useful in treating neurological disorders
    Patent number: 5599814
    Abstract: The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: February 4, 1997
    Assignee: Imperial Chemical Industries, PLC
    Inventors: Thomas M. Bare, Richard B. Sparks
  • Spiro-dihydroisoindole compounds
    Patent number: 5098925
    Abstract: The present invention relates to spiroisoindolines that are antagonists at the phencyclidine receptor of the N-methyl-D-aspartate receptor complex and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides processes for preparing the spiroisoindolines, intermediates useful for their synthesis, pharmaceutical compositions containing them, and methods for their use.
    Type: Grant
    Filed: February 5, 1991
    Date of Patent: March 24, 1992
    Assignee: ICI Americas Inc.
    Inventor: Thomas M. Bare
  • Pyrazolo[3,4-b]pyridine-5-carboxamides and their use as anxiolytic agents
    Patent number: 4745121
    Abstract: This invention relates to pyrazolo[3,4-b]pyridine amides useful as anxiolytic agents.
    Type: Grant
    Filed: September 11, 1985
    Date of Patent: May 17, 1988
    Assignee: ICI Americas Inc.
    Inventor: Thomas M. Bare
  • Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents
    Patent number: 4645838
    Abstract: Compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.7 and R.sup.8 are as described herein, D is oxygen, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: February 24, 1987
    Assignee: ICI Americas Inc.
    Inventors: Thomas M. Bare, Anthony F. Heald
  • Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use
    Patent number: 4552883
    Abstract: Compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have defined values and the N-oxides at the 7-position of the pyrazolo[3,4-b]pyridine ring system and the pharmaceutically-acceptable acid-addition salts thereof, processes for their preparation and use, pharmaceutical compositions, and intermediates for preparing said compounds of the formula (I). The compounds of formula (I) are central nervous system depressants, for example anxiolytic agents.
    Type: Grant
    Filed: May 19, 1983
    Date of Patent: November 12, 1985
    Assignee: ICI Americas Inc.
    Inventor: Thomas M. Bare
  • Pyrazolopyridine cycloalkanones and process for their preparation
    Patent number: 4546104
    Abstract: Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclopenta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyrazolo[4,3-e]pyridinones, useful as anxiolytics having reduced side effects, are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: October 8, 1985
    Assignee: ICI Americas Inc.
    Inventors: James B. Campbell, Jr., Thomas M. Bare
  • CNS-Depressant pyrazolopyridines
    Patent number: 4511568
    Abstract: Compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.7 and R.sup.8 are as described herein, D is oxygen or NR.sup.6, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: April 16, 1985
    Assignee: ICI Americas Inc.
    Inventors: Thomas M. Bare, Anthony F. Heald
  • Heterocyclic tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene urea and phenyl esters of tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene carbamic acid compounds
    Patent number: 4230713
    Abstract: Heterocyclic tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene urea and compounds which are useful as anxiolytic agents in living animals and also some of which act to block acid secretions.
    Type: Grant
    Filed: January 19, 1979
    Date of Patent: October 28, 1980
    Assignee: ICI Americas Inc.
    Inventor: Thomas M. Bare
  • Process of preparing amino ethanols
    Patent number: 4192805
    Abstract: The compounds 2-N-[1,1-hydrogen or C.sub.1 -C.sub.4 -alkyl-2(3,4-methylenedioxyphenyl)ethyl]amino-1-(3-alkoxy-carbonyl or hydroxymethyl-4-benzyloxyphenyl) ethanol compounds, and the process of making these compounds. There is also disclosed a process of making the compounds 2-N-[1,1-hydrogen or C.sub.1 -C.sub.4 -alkyl-2(3,4-methylenedioxyphenyl)ethyl]amino-1-(3-hydroxy-4-hydroxy)ethan ol.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: March 11, 1980
    Assignee: Nicholas International Limited
    Inventors: John T. Suh, Thomas M. Bare
  • Pharmaceutical compositions and methods of treatment with 1-oxo-1H-2-benzothio pyran-3-carboxylic acid derivatives
    Patent number: 4018891
    Abstract: The method comprises administering to an animal a novel pharmaceutical composition containing a substituted-1-oxo-1H-2-benzothiopyran-3-carboxylic acid to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method are:1-Oxo-1H-2-benzothiopyran-3-carboxylic acid, andSodium 6-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate.
    Type: Grant
    Filed: November 17, 1975
    Date of Patent: April 19, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas M. Bare, John T. Suh
  • Method of treatment using 1-oxo-1H-2-benzopyran-3-carboxylic acid derivatives
    Patent number: 3987185
    Abstract: The method comprises administering to an animal an amount of substituted-1-oxo-1H-2-benzopyran-3-carboxylic acid effective to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method is sodium 1-oxo-1H-2-benzopyran-3-carboxylate.
    Type: Grant
    Filed: December 20, 1974
    Date of Patent: October 19, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas M. Bare, John T. Suh
  • 1-Oxo-1H-2-benzothiopyran-3-carboxylic acid derivatives
    Patent number: 3960892
    Abstract: The method comprises administering to an animal a novel pharmaceutical composition containing a substituted-1-oxo-1H-2-benzothiopyran-3-carboxylic acid to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method are:1-Oxo-1H-2-benzothiopyran-3-carboxylic acid, andSodium 6-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate.
    Type: Grant
    Filed: July 3, 1974
    Date of Patent: June 1, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas M. Bare, John T. Shu