Patents by Inventor Thomas M. Brennan

Thomas M. Brennan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4517379
    Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is CH.sub.2 OH or CH.sub.2 OCH.sub.3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R.sup.3, F.sup.4, R.sup.5, R.sup.6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO.sub.2, C.dbd.O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is not greater than six, and when both of R.sup.3 and R.sup.4 or R.sup.5 and R.sup.6 are alkyl they are methyl or ethyl, ##STR3## where one of R.sup.7, R.sup.8, R.sup.
    Type: Grant
    Filed: April 1, 1983
    Date of Patent: May 14, 1985
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Michael E. Hendrick
  • Patent number: 4463252
    Abstract: A night vision goggle system comprising a housing, an optical system accommodated therein and including a pair of eyepiece assemblies, with each assembly slidably mounted for interpupillary adjustment. The assemblies are respectively focusable. The optical system further includes an objective lens assembly, an image intensifier tube provided with concave-faced fiber optics, and a collimator lens assembly, all in axial alignment, and a splitter member. The objective, collimator and eyepiece assemblies feature prescription optics.The goggle system preferably is head mounted via a quick-release connection to a face mask provided with an adjustable strap assembly.
    Type: Grant
    Filed: January 4, 1982
    Date of Patent: July 31, 1984
    Assignee: Baird Corporation
    Inventors: Thomas M. Brennan, Robert M. Burley
  • Patent number: 4454328
    Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is CH.sub.2 OH or CH.sub.2 OCH.sub.3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R.sup.3, R.sup.4, R.sup.5, R.sup.6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO.sub.2, C.dbd.O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is not greater than six, and when both of R.sup.3 and R.sup.4 or R.sup.5 and R.sup.6 are alkyl they are methyl or ethyl, ##STR3## where one of R.sup.7, R.sup.8, R.sup.
    Type: Grant
    Filed: April 1, 1983
    Date of Patent: June 12, 1984
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Michael E. Hendrick
  • Patent number: 4435584
    Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: July 19, 1982
    Date of Patent: March 6, 1984
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4411925
    Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.
    Type: Grant
    Filed: November 5, 1980
    Date of Patent: October 25, 1983
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Michael E. Hendrick
  • Patent number: 4399163
    Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is CH.sub.2 OH or CH.sub.2 OCH.sub.3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butyl-carbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.
    Type: Grant
    Filed: June 26, 1981
    Date of Patent: August 16, 1983
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Michael E. Hendrick
  • Patent number: 4387235
    Abstract: 2-methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gammapyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: October 14, 1981
    Date of Patent: June 7, 1983
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4368331
    Abstract: (2-methyl-3-hydroxy-4h-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydro-pyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: January 11, 1983
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Donald E. Kuhla, Paul D. Weeks
  • Patent number: 4323506
    Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gammapyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: April 6, 1982
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4323298
    Abstract: A wide field of view goggle system with a pair of viewing channels that are mounted on a platform and are constrained for relative lateral and angular movement. Control mechanisms are provided for adjustment of the interpupillary distance between the channels and the angular position of the channels relative to one another. An instantaneous wide field of view is provided by relative angular orientation of the viewing channels in a common, overlapping field of view.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: April 6, 1982
    Assignee: Baird Corporation
    Inventor: Thomas M. Brennan
  • Patent number: 4289704
    Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: July 2, 1980
    Date of Patent: September 15, 1981
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4191693
    Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: March 4, 1980
    Assignee: Pfizer, Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4173572
    Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.
    Type: Grant
    Filed: August 28, 1978
    Date of Patent: November 6, 1979
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4147705
    Abstract: 2-Methyl-3-hydroxy-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: April 3, 1979
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4126624
    Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2(1-hydroxyethyl)-3-alkoxy furans or 2(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.
    Type: Grant
    Filed: November 12, 1976
    Date of Patent: November 21, 1978
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4082717
    Abstract: 2-METHYL-3-HYDROXY-4H-pyran-4-one is prepared by contacting 1(2-furyl)-1-ethanol in aqueous solution with two equivalents of a halogen oxidant at room temperature and then heating until the hydrolysis of the formed 4-halo-dihydropyran intermediate is substantially complete. Other valuable related gamma-pyrones are prepared in analogous manner from appropriate alcohols.
    Type: Grant
    Filed: September 9, 1976
    Date of Patent: April 4, 1978
    Assignee: Pfizer Inc.
    Inventors: Thomas M. Brennan, Daniel P. Brannegan, Paul D. Weeks, Donald E. Kuhla
  • Patent number: 4076978
    Abstract: A tapered or twisted fiber optic bundle having a unidirectional diffuser at an output face thereof defines a fiber optic bundle beam expander. In a viewing system, such a beam expander is provided at the output of an image intensifier tube for unidirectionally spreading rays of an amplified image in a horizontal direction for biocular viewing.
    Type: Grant
    Filed: October 14, 1976
    Date of Patent: February 28, 1978
    Assignee: Baird-Atomic, Inc.
    Inventors: Thomas M. Brennan, Robert M. Burley
  • Patent number: 4073780
    Abstract: Processes for the preparation of 6- D-2-phenyl-2-(4-pyridylformimidoylaminoacetamido)acetamido!penicillanic acid via acylation of 6-aminopenicillanic acid and derivatives thereof.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: February 14, 1978
    Assignee: Pfizer Inc.
    Inventor: Thomas M. Brennan