Patents by Inventor Thomas M. Connolly
Thomas M. Connolly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6838291Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1?-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4?-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.Type: GrantFiled: July 12, 2001Date of Patent: January 4, 2005Assignee: Merck & Co., Inc.Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
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Publication number: 20030212262Abstract: The present invention provides polynucleotides and polypeptides of a human serine racemase. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the serine racemase protein and polypeptides thereof, assays for the presence or expression of serine racemase and assays for the identification of compounds that interact with serine racemase and transgenic animals expressing human serine racemase.Type: ApplicationFiled: October 3, 2002Publication date: November 13, 2003Inventors: Thomas M Connolly, Yuan Liu, Menghang Xia
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Patent number: 6515023Abstract: A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which comprises administering a therapeutically effective but non-toxic amount of such compound to a mammal, preferably a human.Type: GrantFiled: January 30, 2001Date of Patent: February 4, 2003Assignee: Merck & Co., Inc.Inventors: James C. Barrow, Philippe G. Nantermet, Harold G. Selnick, John H. Hutchinson, Michael J. Breslin, Kristen L. Glass, Thomas M. Connolly, Andrew Stern
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Publication number: 20020034730Abstract: The present invention is directed to the radioligand compound, [35S]-radiolabeled (+)-N-[1′-(6-cyano-1,2,3,4-tetrahydro-2(R)-naphthalenyl)-3,4-dihydro-4(R)-hydoxyspiro[2H-1-benzopyran-2,4′-piperidin]-6-yl]methanesulfonamide. Also within the scope of this invention is a method for identifying compounds that bind to the IKr channel, and may have antiarrhythmic activity.Type: ApplicationFiled: July 12, 2001Publication date: March 21, 2002Inventors: John W. Butcher, David A. Claremon, Thomas M. Connolly, Jerzy Karczewski, Kenneth S. Koblan, Matthew J. Kostura, Nigel J. Liverton, Dennis C. Dean, David G. Melillo
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Publication number: 20020007045Abstract: A thrombin receptor antagonist having the formula 1Type: ApplicationFiled: January 30, 2001Publication date: January 17, 2002Inventors: James C. Barrow, Philippe G. Nantermet, Harold G. Selnick, John H. Hutchinson, Michael J. Breslin, Kristen L. Glass, Thomas M. Connolly, Andrew Stern
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Patent number: 5681926Abstract: Peptides having the general sequence A-B-C-D-E-F-Z wherein A is Ala, B is pFPhe, C is, for example, Arg, D is Cha, E is, for example, hArg, F is, for example, Tyr, and Z is, for example NH.sub.2. The peptides are useful for promoting wound healing and arresting bleeding in a patient.Type: GrantFiled: December 15, 1995Date of Patent: October 28, 1997Assignee: Merck & Co., Inc.Inventors: Daniel F. Veber, Ruth F. Nutt, Dong-Mei Feng, Robert J. Gould, Thomas M. Connolly
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Patent number: 5613676Abstract: A sporting net which can be utilized either as a hockey net or a basketball hoop. The apparatus includes a center post having a basketball hoop and its upper end. Furthermore, two linkages are pivotally secured at opposing locations at the intermediate extent of the center post. A hockey net is secured in between these two linkages. In order to facilitate storage of the sporting net, the linkages are pivotal between a first use orientation, wherein they extend laterally from the post then downwardly to abut a recipient surface and a second storage orientation wherein they are positioned generally next to the post.Type: GrantFiled: April 1, 1996Date of Patent: March 25, 1997Inventor: Thomas M. Connolly
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Patent number: 5457177Abstract: The radioligands are six amino acid peptides having iodinated tyrosine at amino acid position six, including Ala-pFPhe-hArg-Cha-hArg-Tyr(I)-NH.sub.2, which mimic the activated form of the thrombin receptor protein. Thrombin receptor radioligands of the present invention are useful for screening for thrombin receptor antagonists.Type: GrantFiled: June 16, 1993Date of Patent: October 10, 1995Assignee: Merck & Co., Inc.Inventors: Daniel F. Veber, Ruth F. Nutt, Dong-mei Feng, Robert J. Gould, Thomas M. Connolly
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Patent number: 5340726Abstract: A protein which inhibits collagen-stimulated platelet aggregation. The protein has a molecular weight of approximately 17,000. A method of isolating the protein from Ornithodoros moubata and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.Type: GrantFiled: August 16, 1993Date of Patent: August 23, 1994Assignee: Merck & Co., Inc.Inventors: Thomas M. Connolly, Paul M. Keller, Lloyd H. Waxman
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Patent number: 5324715Abstract: A protein isolated from crude Haementeria officinalis extract which blocks stimulation of platelet aggregation by collagen. The protein has a molecular weight of approximately 16,000. A method of isolating the protein and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.Type: GrantFiled: April 7, 1993Date of Patent: June 28, 1994Assignee: Merck & Co., Inc.Inventors: Thomas M. Connolly, Paul M. Keller
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Patent number: 5321010Abstract: The invention comprises proteinaceous substances isolated from crude Ornithodoros moubata extract which inhibit adhesion of platelets to collagen. These substances do not inhibit platelet adhesion to fibrinogen, and are therefore particularly useful for inhibiting adhesion of platelets to collagen when simultaneous inhibition of platelet adhesion to fibrinogen is undesired. They are particularly useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.Type: GrantFiled: December 10, 1991Date of Patent: June 14, 1994Assignee: Merck & Co., Inc.Inventors: Thomas M. Connolly, Michael Neeper, Lloyd Waxman
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Patent number: 5179082Abstract: A method for blocking platelet adhesion to collagen by contacting platelets with a polypeptide having one of the following sequences:NH.sub.2 (Ch) Ala Arg Gly Asp (Cx) COOH (i)NH.sub.2 (Ch) Ala Ala Gly Asp (Cx) COOH (ii)NH.sub.2 (Ch) Ala Arg Tyr Asp (CX) COOH (iii)NH.sub.2 (Ch) Ala Arg Gly Asp (Cy) Z (iv)wherein Ch, Cx, Cy are defined amino acid sequences or conservatively substituted amino acid sequences, and Z is NH.sub.2 or COOH.Type: GrantFiled: February 27, 1991Date of Patent: January 12, 1993Assignee: Merck & Co., Inc.Inventors: Thomas M. Connolly, Jerzy Karczewski
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Patent number: 4038660Abstract: Microwave absorbers reduce radar cross-sections of airborne objects by attenuating reflectivity values. In Jaumann absorbers laminated layers are placed on the reflecting surfaces, the laminated layers being lossy layers separated by dielectric spacing layers. From the point of view of accuracy and reproducibility Jaumann absorbers have been difficult to construct. A mode of fabrication overcoming these difficulties is provided herein.Type: GrantFiled: August 5, 1975Date of Patent: July 26, 1977Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Thomas M. Connolly, Eino J. Luoma
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Patent number: 4027384Abstract: Microwave absorbers reduce radar cross-sections of airborne objects by attenuating reflectivity values. In Jaumann absorbers laminated layers are placed on the reflecting surfaces, the laminated layers being lossy layers separated by dielectric spacing layers. From the point of view of accuracy and reproducibility Jaumann absorbers have been difficult to construct. A mode of fabrication overcoming these difficulties is provided herein.Type: GrantFiled: November 19, 1976Date of Patent: June 7, 1977Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Thomas M. Connolly, Eino J. Luoma